Determination of paracetamol in the tablet. 5 tablets of paracetamol (each tab 5 g weight and contains 500 mg paracetamol drug) were weighed and powdered. Powdered tablet 1 g is eq... Determination of paracetamol in the tablet. 5 tablets of paracetamol (each tab 5 g weight and contains 500 mg paracetamol drug) were weighed and powdered. Powdered tablet 1 g is equivalent to 100 mg of paracetamol was weighed and dissolved in the solvent and then adjust the volume up to 100 ml. From that 10 ml of solution was withdrawn and taken into 100 ml volumetric flask. The volume was adjusted with solvent up to 100 ml. then, 3 ml was transferred into the cuvette and measured the desired wavelength. The absorbance for the unknown paracetamol sample in the tablet is 0.097
Understand the Problem
The question describes a procedure for determining the amount of paracetamol in a tablet using spectrophotometry. It involves weighing and powdering tablets, dissolving the powder, diluting the solution, and measuring the absorbance. We need to determine the concentration of paracetamol in the original tablet based on the given information.
Answer
The concentration of paracetamol can be calculated using the provided absorbance and dilution factors.
To determine the concentration of paracetamol, we need to consider the dilution factors. 1 g of powdered tablet (containing 100 mg of paracetamol) was dissolved in 100 ml. Then, 10 ml of this solution was diluted to 100 ml. Therefore, a 1 g of powdered tablet is diluted to 100 ml and then diluted again by taking 10 ml to 100 ml. The absorbance for this final solution is equal to 0.097.
Answer for screen readers
To determine the concentration of paracetamol, we need to consider the dilution factors. 1 g of powdered tablet (containing 100 mg of paracetamol) was dissolved in 100 ml. Then, 10 ml of this solution was diluted to 100 ml. Therefore, a 1 g of powdered tablet is diluted to 100 ml and then diluted again by taking 10 ml to 100 ml. The absorbance for this final solution is equal to 0.097.
More Information
Paracetamol, also known as acetaminophen, is a widely used over-the-counter analgesic and antipyretic medication.
Tips
Pay close attention to detail to the units (mg vs g, ml vs L) to avoid errors when calculating concentrations.
Sources
- Quality Evaluation of Locally Manufactured Paracetamol Tablets in ... - pmc.ncbi.nlm.nih.gov
- Development and Validation of A UV Spectroscopic Method for ... - orientjchem.org
- Paracetamol (Acetaminophen) - Pharmaceutical Drugs - NCBI - ncbi.nlm.nih.gov
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