What potential mechanism does the C-terminal domain of mGluRs contribute to?
Understand the Problem
The question is asking about the role of the C-terminal domain of metabotropic glutamate receptors (mGluRs) and which specific mechanism it contributes to, with multiple choice options provided.
Answer
The C-terminal domain of mGluRs modulates G protein coupling, receptor sensitivity, regulation, and trafficking.
The C-terminal domain of mGluRs contributes to modulating G protein coupling, receptor sensitivity, movement, regulation, trafficking, and phosphorylation modifications.
Answer for screen readers
The C-terminal domain of mGluRs contributes to modulating G protein coupling, receptor sensitivity, movement, regulation, trafficking, and phosphorylation modifications.
More Information
The C-terminal domain of metabotropic glutamate receptors (mGluRs) is crucial for the regulation of intracellular signaling. It undergoes modifications such as phosphorylation and is involved in processes like receptor sensitization and movement, helping modulate the signaling pathways these receptors influence.
Tips
A common mistake is to overlook the role of the C-terminal domain in receptor trafficking and regulation, focusing solely on G protein coupling.
Sources
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and... - pmc.ncbi.nlm.nih.gov
- Structure of metabotropic glutamate receptor C-terminal domains in... - pmc.ncbi.nlm.nih.gov
- Metabotropic Glutamate Receptor - an overview | ScienceDirect Topics - sciencedirect.com
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