What occurs when a signal binds to a receptor in the Ras activation pathway?
Understand the Problem
The question is about the process involved when a signal binds to a receptor in the Ras activation pathway, specifically asking which of the provided options accurately describes what happens during this process.
Answer
Signal binding activates RTKs, leading to a signaling cascade.
Signal binding to a receptor in the Ras activation pathway leads to receptor autophosphorylation, activation of receptor tyrosine kinases (RTKs), and eventually triggers a downstream signaling cascade involving proteins like Raf and MAPK.
Answer for screen readers
Signal binding to a receptor in the Ras activation pathway leads to receptor autophosphorylation, activation of receptor tyrosine kinases (RTKs), and eventually triggers a downstream signaling cascade involving proteins like Raf and MAPK.
More Information
The Ras pathway is important for regulating cell growth, and its dysregulation is a common factor in cancer development. RTKs, when activated by a bound signal, become phosphorylated and initiate a cascade that amplifies the signal to affect gene expression.
Tips
A common mistake is not identifying the initial step of receptor autophosphorylation, crucial for subsequent signaling events.
Sources
- The Ras/Raf/MAPK Pathway - Journal of Thoracic Oncology - jto.org
- Activation of Ras by receptor tyrosine kinases - PubMed - pubmed.ncbi.nlm.nih.gov
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