What is the result of mGluR1 activation?
Understand the Problem
The question is asking about the physiological effects of activating mGluR1, a type of metabotropic glutamate receptor. It presents several potential outcomes and requires the identification of the correct one based on knowledge of neurobiology.
Answer
Activation of mGluR1 induces synaptic plasticity as long-term depression (LTD) at specific brain synapses.
The final answer is activation of mGluR1 leads to the activation of the Gq/11 pathway and induces synaptic plasticity at the parallel fiber-Purkinje cell synapse (PF-PC) in the form of long-term depression (LTD).
Answer for screen readers
The final answer is activation of mGluR1 leads to the activation of the Gq/11 pathway and induces synaptic plasticity at the parallel fiber-Purkinje cell synapse (PF-PC) in the form of long-term depression (LTD).
More Information
Activation of mGluR1, a type of metabotropic glutamate receptor, influences synaptic connections in the brain, playing an essential role in learning and memory by modifying synaptic strength through pathways like Gq/11.
Tips
A common mistake is confusing mGluR1 with other glutamate receptor types, as they each have distinct functions and pathways.
Sources
- Neuroscience article on - ScienceDirect - sciencedirect.com
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