What is the most likely infectious outcome in an individual with a deficiency in complement proteins?
Understand the Problem
The question asks about the most likely infectious outcome in an individual with a deficiency in complement proteins. Complement proteins play a crucial role in the immune system, particularly in opsonization (enhancing phagocytosis), inflammation, and direct lysis of pathogens. A deficiency in these proteins will impair these functions, making the individual more susceptible to certain types of infections.
Answer
Severe, recurrent infections, autoimmune diseases, and invasive meningococcal disease are likely outcomes.
Individuals with complement protein deficiencies are highly susceptible to severe, recurrent infections, especially those of the respiratory tract. They are also at risk for autoimmune diseases and, in some cases, invasive meningococcal disease.
Answer for screen readers
Individuals with complement protein deficiencies are highly susceptible to severe, recurrent infections, especially those of the respiratory tract. They are also at risk for autoimmune diseases and, in some cases, invasive meningococcal disease.
More Information
Complement proteins play a vital role in the immune system. Deficiencies can be inherited or acquired and can lead to a range of health issues beyond infections.
Tips
It is easy to focus solely on infections, but complement deficiencies also increase the risk of autoimmune diseases.
Sources
- Complement Deficiency - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Infections of People with Complement Deficiencies and Patients ... - pmc.ncbi.nlm.nih.gov
- Complement System Function - Cleveland Clinic - my.clevelandclinic.org
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