Match the diuretic with its primary site of action within the nephron and its effect on calcium excretion: Furosemide | Thick ascending limb; increases urinary calcium excretion Th... Match the diuretic with its primary site of action within the nephron and its effect on calcium excretion: Furosemide | Thick ascending limb; increases urinary calcium excretion Thiazides | Distal convoluted tubule; reduces urinary calcium excretion Amiloride | Proximal tubule; primarily affects bicarbonate reabsorption, indirect effect on calcium Acetazolamide | Collecting duct; potassium-sparing, minimal effect on calcium
Understand the Problem
This question requires matching different types of diuretics with their corresponding site of action within the nephron and their effect on calcium excretion. It's a matching question where you need to associate each diuretic with its location of impact in the kidney and how it influences calcium levels in urine.
Answer
Furosemide: Thick ascending limb, increases calcium excretion. Thiazides: Distal convoluted tubule, reduces calcium excretion. Amiloride: Collecting duct, minimal effect on calcium. Acetazolamide: Proximal tubule, indirect effect on calcium.
Here's the matching of diuretics with their primary site of action and effect on calcium excretion:
- Furosemide: Thick ascending limb; increases urinary calcium excretion
- Thiazides: Distal convoluted tubule; reduces urinary calcium excretion
- Amiloride: Collecting duct; potassium-sparing, minimal effect on calcium
- Acetazolamide: Proximal tubule; primarily affects bicarbonate reabsorption, indirect effect on calcium
Answer for screen readers
Here's the matching of diuretics with their primary site of action and effect on calcium excretion:
- Furosemide: Thick ascending limb; increases urinary calcium excretion
- Thiazides: Distal convoluted tubule; reduces urinary calcium excretion
- Amiloride: Collecting duct; potassium-sparing, minimal effect on calcium
- Acetazolamide: Proximal tubule; primarily affects bicarbonate reabsorption, indirect effect on calcium
More Information
Diuretics affect different parts of the nephron and have varying effects on electrolyte excretion, including calcium. This is important in managing conditions like hypercalcemia or kidney stones.
Tips
It's easy to confuse the sites of action and calcium effects of different diuretics. Focus on the primary site and whether the diuretic increases or decreases calcium excretion to help remember the pairings.
Sources
- Therapeutic Uses of Diuretic Agents - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Diuretics: a review - David Wile, 2012 - journals.sagepub.com
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