In the given pedigree, assuming the disorder is autosomal dominant, what is the genotype of individual I-2?
Understand the Problem
The question presents a pedigree chart and asks for the genotype of individual I-2, assuming the disorder is autosomal dominant. To solve this, we must understand how autosomal dominant inheritance works and analyze the pedigree to deduce the possible genotypes of I-2 and eliminate options based on the information provided.
Answer
The genotype of individual I-2 is either AA or Aa.
If individual I-2 in the pedigree has an autosomal dominant disorder, their genotype must include at least one dominant allele (A). Since they are affected, the genotype is either homozygous dominant (AA) or heterozygous (Aa). More information is needed to determine which one.
Answer for screen readers
If individual I-2 in the pedigree has an autosomal dominant disorder, their genotype must include at least one dominant allele (A). Since they are affected, the genotype is either homozygous dominant (AA) or heterozygous (Aa). More information is needed to determine which one.
More Information
In autosomal dominant inheritance, individuals with at least one copy of the dominant allele will express the trait. Therefore, knowing the phenotypes of their parents and offspring can help determine the exact genotype.
Tips
A common mistake is assuming that an affected individual must be homozygous dominant. Remember to consider the possibility of heterozygotes in dominant inheritance patterns.
Sources
- Pedigrees review (article) | Heredity - Khan Academy - khanacademy.org
- 6.2: Pedigrees review - Biology LibreTexts - bio.libretexts.org
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