In the context of gout, why is the metatarsophalangeal joint of the big toe notably affected?
Understand the Problem
The question asks for the reason why the metatarsophalangeal joint of the big toe is particularly affected in cases of gout. Gout is caused by the accumulation of uric acid crystals in the joints, leading to inflammation and pain. The question requires understanding the physiological factors that make this specific joint more susceptible to urate crystal deposition.
Answer
The metatarsophalangeal joint of the big toe is often affected in gout due to its lower temperature, which promotes uric acid crystallization.
In gout, the metatarsophalangeal joint of the big toe is often affected because its lower temperature promotes the crystallization of uric acid. Uric acid crystallization in the joint leads to inflammation and pain.
Answer for screen readers
In gout, the metatarsophalangeal joint of the big toe is often affected because its lower temperature promotes the crystallization of uric acid. Uric acid crystallization in the joint leads to inflammation and pain.
More Information
The condition of gout in the big toe is called podagra.
Tips
A common misconception is that gout is solely caused by high uric acid levels. While elevated uric acid is a risk factor, other factors like temperature and local joint health also play significant roles.
Sources
- Why Gout Affects the Big Toe First - decaropodiatry.com
- Revisiting the pathogenesis of podagra: why does gout target the foot? - pmc.ncbi.nlm.nih.gov
- Gout Symptoms and Diagnosis | Johns Hopkins Arthritis Center - hopkinsarthritis.org
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