If a toxin prevents synaptic transmission by interfering with calcium channel function at the presynaptic terminal, what specific process is being directly disrupted?
Understand the Problem
The question asks which process is directly disrupted when a toxin interferes with calcium channel function at the presynaptic terminal, thereby preventing synaptic transmission. We need to identify the step in synaptic transmission that relies on calcium influx.
Answer
Neurotransmitter release is directly disrupted, which depends on calcium influx at the presynaptic terminal.
The toxin directly disrupts the calcium-dependent process of neurotransmitter release. Calcium influx through calcium channels at the presynaptic terminal is essential for triggering the fusion of synaptic vesicles with the plasma membrane, leading to the release of neurotransmitters into the synaptic cleft.
Answer for screen readers
The toxin directly disrupts the calcium-dependent process of neurotransmitter release. Calcium influx through calcium channels at the presynaptic terminal is essential for triggering the fusion of synaptic vesicles with the plasma membrane, leading to the release of neurotransmitters into the synaptic cleft.
More Information
Many toxins interfere with synaptic transmission by targeting different steps in the process. Some toxins block calcium channels directly, while others interfere with the proteins involved in vesicle fusion.
Tips
It is easy to confuse the roles of pre-synaptic and post-synaptic neurons. Remember that the pre-synaptic neuron releases neurotransmitters after calcium influx.
Sources
- Mechanisms of Neurotransmitter Release (Section 1, Chapter 5 ... - nba.uth.tmc.edu
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