1. Which of these antihypertensives will you recommend for a patient with concomitant renal disease? A. Diuretics B. Beta blockers C. ACE inhibitors D. Calcium channel blockers 2.... 1. Which of these antihypertensives will you recommend for a patient with concomitant renal disease? A. Diuretics B. Beta blockers C. ACE inhibitors D. Calcium channel blockers 2. One of the adverse effects of misoprostol is A. Abortion B. Constipation C. Diarrhoea D. Nephritis 3. Misoprostol stimulates the release of …. A. Cytokines B. Prostaglandin E2 C. Histamine D. Leukotriene 4. What route of administration is the drug placed under the tongues where the drug is absorbed through the mucous membrane that lines the inside of the cheeks? A. Sublingual B. Oral C. Buccal D. Retroglossal 5. …….. covers the ulcers in peptic ulcer to promote healing. A. Omeprazole B. Cimetidine C. Misoprostol D. Sucralfate 6. Which of these is a potassium sparing diuretic? A. Eplerenone B. Acarbose C. Cimetidine D. Omeprazole 7. All these are adverse effects of diuretics, except. A. Excessive Na+ and water loss B. Increase in urinary frequency C. Erectile dysfunction D. GI disturbance 8. The LD50 and ED50 of drug A are 95 and 5 respectively. Calculate the therapeutic index A. 19 B. 20 C. 21 D. 22 9. Which of these antibiotics are used for the management of H. pylori infection?
Understand the Problem
The questions are asking about various pharmacological concepts, including the recommendations for antihypertensives in patients with renal disease, adverse effects of specific drugs, drug actions, routes of administration, and aspects related to drug safety and efficacy. They require knowledge of pharmacology and medicine.
Answer
1. ACE inhibitors 2. Diarrhoea 3. Prostaglandin E2 4. Buccal 5. Sucralfate 6. Eplerenone 7. GI disturbance 8. 19
- ACE inhibitors 2. Diarrhoea 3. Prostaglandin E2 4. Buccal 5. Sucralfate 6. Eplerenone 7. GI disturbance 8. 19
Answer for screen readers
- ACE inhibitors 2. Diarrhoea 3. Prostaglandin E2 4. Buccal 5. Sucralfate 6. Eplerenone 7. GI disturbance 8. 19
More Information
ACE inhibitors are preferred for patients with renal disease, as they help protect kidney function. Misoprostol's primary adverse effect is diarrhea due to its role in increasing fluid secretion in the intestines. Prostaglandin E2 is a prostaglandin released due to misoprostol. Eplerenone is a potassium-sparing diuretic. Sucralfate coats ulcers to enhance healing, and the therapeutic index of drug A is calculated as 19.
Tips
A common mistake when calculating the therapeutic index is forgetting to divide LD50 by ED50. For administrators of drugs, confusing sublingual with buccal and oral routes is also frequent.
Sources
- Antihypertensive Medications - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Which of these antihypertensives will you recommend for a patient... - gauthmath.com
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