Zoonotic Viruses in Virology - BMS2037

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Which term is used to describe the transmission of a pathogen from an animal to a human?

Spillover

What is the place where a pathogen normally lives and reproduces known as?

Reservoir

What is the release of a virus from an infected person into the environment called?

Shedding

Which type of viruses pose a bigger risk for the Global South?

<p>Zoonotic viruses</p> Signup and view all the answers

What percentage of all human viruses known today were unknown at the end of World War II?

<p>90%</p> Signup and view all the answers

What is the term for a pathogen/virus that has spread from animals to humans?

<p>Zoonosis</p> Signup and view all the answers

What does the term 'Enzootic' refer to?

<p>The maintenance of an infection in a population without the need for external inputs.</p> Signup and view all the answers

What is the primary mode of transmission for Ebola virus?

<p>Transmission through direct contact with body fluids of infected humans/animals or fomite.</p> Signup and view all the answers

What is the incubation period for Nipah virus?

<p>4 to 14 days</p> Signup and view all the answers

What is the case fatality rate for Hendra virus?

<p>40% to 75%</p> Signup and view all the answers

What is the R0 in the context of prioritizing zoonotic viruses?

<p>Basic reproduction number or R naught or R zero, which varies for different viruses.</p> Signup and view all the answers

What is one health approach in the context of eradicating Rabies epidemics?

<p>Management of rabies in animals as a key public health intervention.</p> Signup and view all the answers

What is the evolutionary potential used for prioritizing zoonotic viruses?

<p>The R0 or basic reproduction number.</p> Signup and view all the answers

What is the characteristic symptom observed in severe cases of Ebolavirus disease?

<p>Vomiting, diarrhea, rash, and decreased liver and kidney function.</p> Signup and view all the answers

What does 'Spillover' refer to in the context of viral diseases?

<p>'Infection' when the spillover event occurs.</p> Signup and view all the answers

What is meant by 'Epizootic' viral disease?

<p>A special place (outbreak) where viral disease occurs in non-human animals.</p> Signup and view all the answers

What is used as a diagnostic method for Nipah virus?

<p>Detection of viral RNA using PCR technique.</p> Signup and view all the answers

What is the primary treatment for Nipah virus infection?

<p>Supportive care</p> Signup and view all the answers

How is the diagnosis of Nipah virus infection typically confirmed?

<p>Real time polymerase chain reaction (RT-PCR)</p> Signup and view all the answers

What is the incubation period for Crimea-Congo Hemorrhagic Fever virus?

<p>7 days</p> Signup and view all the answers

What are the initial signs and symptoms of Nipah virus infection?

<p>Fever, fatigue, and myalgia</p> Signup and view all the answers

What causes the severe symptoms of Crimea-Congo Hemorrhagic Fever virus infection?

<p>High pro-inflammatory cytokines</p> Signup and view all the answers

How are patients with Crimea-Congo Hemorrhagic Fever virus treated?

<p>Supportive care</p> Signup and view all the answers

What is the main method of detecting the presence of CCHFV in patients?

<p>Real time polymerase chain reaction (RT-PCR)</p> Signup and view all the answers

What is the recommended way to prevent CCHFV infections?

<p>Vector control strategies</p> Signup and view all the answers

What do researchers aim to target with the development of an anti-tick vaccine?

<p>Attracting immune cells to tick saliva proteins</p> Signup and view all the answers

What is the classification of the Crimean-Congo Hemorrhagic Fever virus?

<p>Enveloped, negative single-stranded RNA genome</p> Signup and view all the answers

What is the biggest amino acids diversity in CCHFV linked to?

<p>Different geographic localizations</p> Signup and view all the answers

What is the main way of detecting viral RNA in patients with CCHFV?

<p>Real time polymerase chain reaction (RT-PCR)</p> Signup and view all the answers

Zoonotic viruses are a major risk for the Global North.

<p>False</p> Signup and view all the answers

Spillover always causes the human to get sick or transmit the pathogen to other humans.

<p>False</p> Signup and view all the answers

Shedding of a virus from an infected person into the environment is not infectious.

<p>False</p> Signup and view all the answers

Over 90% of all human viruses known today were known at the end of World War II.

<p>False</p> Signup and view all the answers

Enzootic viral diseases refer to diseases that are not present in animals.

<p>False</p> Signup and view all the answers

Spillover refers to the transmission of a pathogen from a human to an animal.

<p>False</p> Signup and view all the answers

A vaccine is available for Nipah virus.

<p>False</p> Signup and view all the answers

The main tests used for Nipah virus detection are RT-PCR and ELISA.

<p>True</p> Signup and view all the answers

Crimea-Congo Hemorrhagic Fever virus is exclusively hosted by cattle.

<p>False</p> Signup and view all the answers

Nipah virus infection is initially suspected based on specific signs and symptoms.

<p>False</p> Signup and view all the answers

The incubation period for Crimea-Congo Hemorrhagic Fever virus is 7 days.

<p>True</p> Signup and view all the answers

Ribavirin is a specific treatment for Crimea-Congo Hemorrhagic Fever virus.

<p>False</p> Signup and view all the answers

The diagnosis of CCHFV is very easy due to high antibody counts in patients.

<p>False</p> Signup and view all the answers

Development of an anti-tick vaccine aims to target tick saliva proteins to attract immune cells to the place of infection.

<p>True</p> Signup and view all the answers

CCHF outbreaks have a case fatality rate of 40%.

<p>True</p> Signup and view all the answers

Three billion people globally are at risk of infection from Nipah virus.

<p>True</p> Signup and view all the answers

The biggest amino acids diversities in CCHFV are linked to geographic localization.

<p>True</p> Signup and view all the answers

Zoonotic viruses can only be transmitted from animals to humans and not the other way around.

<p>False</p> Signup and view all the answers

The spillover event requires the recipient cells to have the right receptors in order for the virus exchange to take place.

<p>True</p> Signup and view all the answers

The closer the host is genetically to the virus source, the less likely it is to have similar cell receptors.

<p>False</p> Signup and view all the answers

Rabies can be eradicated through a One Health approach involving integrated controls, vaccination campaigns, and collaboration between veterinary and medical doctors.

<p>True</p> Signup and view all the answers

The Ebola virus has an incubation period ranging from 3 days to 3 weeks.

<p>True</p> Signup and view all the answers

Nipah virus can be transmitted from infected bats or pigs, as well as through contaminated food or human-to-human contact.

<p>True</p> Signup and view all the answers

The Nipah virus has an incubation period of 4 to 14 days.

<p>True</p> Signup and view all the answers

Ebolavirus kills approximately 50% of those infected with the virus.

<p>True</p> Signup and view all the answers

Ebolavirus spreads through direct contact with body fluids of infected humans or animals, or through fomite transmission.

<p>True</p> Signup and view all the answers

Diagnosing the Nipah virus infection typically involves isolating the virus, detecting its RNA, or detecting antibodies against the virus in a person's blood.

<p>True</p> Signup and view all the answers

The case fatality rate for Hendra virus is approximately 60%.

<p>True</p> Signup and view all the answers

Study Notes

  • Dr. Marine Petit is a virology expert, and her lectures cover various topics in virology, including Zoonotic viruses.
  • Zoonotic viruses are those that spread from animals to humans.
  • Important Zoonotic viruses include Viral Zoonoses, which can be categorized as Viral Zoonoses with different modes of transmission: Vector Borne, Food Borne, and Air Borne.
  • Over 90% of all human viruses today were unknown at the end of World War II.
  • Zoonotic viruses pose a bigger risk for the Global South.
  • Spillover is the transmission of a pathogen from an animal to a human. It can occur through contact or infection.
  • Contact Spillover is a chance event that requires the recipient cells to have the right receptors for the virus to infect.
  • The closest host genetically has a higher chance of getting similar cell receptors.
  • Spillover can lead to the transmission of viruses from an infected person to other people, completing the jump from animal to human.
  • Viral Zoonoses research includes recent and upcoming spillover in human populations, such as Coronavirus, Ebola, Nipah virus, and Crimea-Congo hemorrhagic fever.
  • Prioritization of research on Viral Zoonoses is based on various factors, including human transmissibility, case fatality rate, and available countermeasures.
  • For instance, the eradication of Rabies is successful via the One Health approach, which involves managing rabies in animals as a key public health intervention.
  • Rabies is a zoonosis that can be diagnosed and treated through methods like isolating the virus, detecting its RNA or proteins, or detecting antibodies against the virus.
  • Other zoonoses, such as Nipah virus, have no treatment or vaccine available and require a supportive care approach.
  • Crimea-Congo hemorrhagic fever is another zoonosis with a high case fatality rate and no treatment or vaccine. Its diagnosis is challenging due to the low antibody detection in patients and the hazardous nature of testing.
  • Prevention strategies include research on tick-virus interactions to develop anti-tick vaccines and vector control strategies.
  • BSL-4 facilities are crucial for the diagnosis and treatment of zoonotic viruses, which can be highly infectious and hazardous.

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