Questions and Answers
What class is Zidovudine (Retrovir)?
When do you give Zidovudine (Retrovir)? (Select all that apply)
What is the mechanism of action of Zidovudine (Retrovir)?
Uses zidovudine instead of thymidine, terminating the growing chain and creating a defective DNA strand.
What are common adverse effects of Zidovudine (Retrovir)? (Select all that apply)
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What are other adverse effects of Zidovudine (Retrovir)? (Select all that apply)
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What are the serious adverse effects of Zidovudine (Retrovir)? (Select all that apply)
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What are contraindications of Zidovudine (Retrovir)?
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What can combining Zidovudine (Retrovir) with other antiretroviral drugs contribute to?
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What are nursing implications for Zidovudine (Retrovir)?
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Study Notes
Zidovudine (Retrovir) Overview
- Zidovudine is classified as an NRTI (nucleoside reverse transcriptase inhibitor), essential in antiretroviral therapy.
Administration Uses
- Prescribed for treating HIV infection.
- Used in post-exposure prophylaxis for HIV.
- Administered to reduce perinatal transmission from mother to child during pregnancy.
Mechanism of Action
- Works by replacing thymidine with zidovudine, leading to the termination of the growing viral DNA strand and the production of defective DNA.
Common Adverse Effects
- Notable adverse effects include anemia and neutropenia, which require monitoring.
Additional Adverse Effects
- Other side effects can include nausea, anorexia, diarrhea, fatigue, myalgia, and headaches.
Serious Adverse Effects
- May cause severe toxicity to bone marrow, central nervous system effects, and potentially fatal lactic acidosis.
Contraindications
- Contraindicated in patients with preexisting anemia, neutropenia, renal or hepatic impairment, patients on drugs that suppress bone marrow function, and those using St. John's Wort.
Drug Interactions
- Combining Zidovudine with other antiretroviral medications can increase the risk of lactic acidosis and hepatomegaly.
Nursing Implications
- Monitor lab results, watch for adverse reactions, manage opportunistic infections, and ensure patient adherence to therapy.
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Description
Test your knowledge on Zidovudine (Retrovir) with these flashcards. Covering its class, usage in HIV treatment, and mechanism of action, this quiz is perfect for students or healthcare professionals looking to enhance their understanding of this essential antiretroviral medication.
