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Questions and Answers
What is the mechanism of action of AZT?
What is the mechanism of action of AZT?
- Competitively inhibits RNA dependent DNA polymerase of HIV (correct)
- Enhances the immune response against retroviruses
- Inhibits viral entry into host cells
- Stimulates the production of TTP in human cells
What is the oral bioavailability of AZT?
What is the oral bioavailability of AZT?
- 80-90%
- 40-50%
- 60-70% (correct)
- 20-30%
What is the effect of food on the absorption rate of AZT?
What is the effect of food on the absorption rate of AZT?
- Reduces absorption rate, especially after high carbohydrate meals (correct)
- Increases absorption rate, especially after high fat meals
- Has no effect on absorption rate
- Causes complete inhibition of absorption
What is the selectivity of Zidovudine based on?
What is the selectivity of Zidovudine based on?
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What is the effect of AZT on intracellular TTP?
What is the effect of AZT on intracellular TTP?
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What is the effect of AZT on human myeloid and erythroid progenitor cell growth?
What is the effect of AZT on human myeloid and erythroid progenitor cell growth?
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What is the mechanism of action of AZT triphosphate?
What is the mechanism of action of AZT triphosphate?
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What is the selectivity of Zidovudine based on?
What is the selectivity of Zidovudine based on?
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What is the oral bioavailability of AZT?
What is the oral bioavailability of AZT?
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What are the CSF levels of AZT in adults compared to plasma levels?
What are the CSF levels of AZT in adults compared to plasma levels?
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