ZIDOVUDINE (AZT) Quiz
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Questions and Answers

What is the mechanism of action of AZT?

  • Competitively inhibits RNA dependent DNA polymerase of HIV (correct)
  • Enhances the immune response against retroviruses
  • Inhibits viral entry into host cells
  • Stimulates the production of TTP in human cells

    • What is the oral bioavailability of AZT?

  • 80-90%
  • 40-50%
  • 60-70% (correct)
  • 20-30%

    • What is the effect of food on the absorption rate of AZT?

  • Reduces absorption rate, especially after high carbohydrate meals (correct)
  • Increases absorption rate, especially after high fat meals
  • Has no effect on absorption rate
  • Causes complete inhibition of absorption

    • What is the selectivity of Zidovudine based on?

    <p>Greater affinity for HIV reverse transcriptase than human polymerases</p> Signup and view all the answers

    What is the effect of AZT on intracellular TTP?

    <p>Reduces intracellular TTP by inhibiting cellular thymidilate kinase</p> Signup and view all the answers

    What is the effect of AZT on human myeloid and erythroid progenitor cell growth?

    <p>It inhibits their growth at low concentrations</p> Signup and view all the answers

    What is the mechanism of action of AZT triphosphate?

    <p>Competitively inhibits RNA dependent DNA polymerase of HIV</p> Signup and view all the answers

    What is the selectivity of Zidovudine based on?

    <p>Greater affinity for HIV reverse transcriptase than human polymerases</p> Signup and view all the answers

    What is the oral bioavailability of AZT?

    <p>60-70%</p> Signup and view all the answers

    What are the CSF levels of AZT in adults compared to plasma levels?

    <p>~60-65% of plasma levels</p> Signup and view all the answers

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