Podcast
Questions and Answers
Which biomarker is associated with squamous cell carcinoma of the lung?
Which biomarker is associated with squamous cell carcinoma of the lung?
- CYFRA 21-1 (correct)
- Chromogranin A
- Histaminase
- Ferritin
Which of the following is a marker for adrenal or pituitary cancer?
Which of the following is a marker for adrenal or pituitary cancer?
- Gastrin
- Insulin-like growth factor
- Metanephrines
- DHEA (correct)
Which biomarker indicates the presence of multiple myeloma?
Which biomarker indicates the presence of multiple myeloma?
- IgA (correct)
- Ferritin
- Galactosyltransferase
- P 21 protein
What is the specific cancer marker for ovarian cancer?
What is the specific cancer marker for ovarian cancer?
Which of the following markers is associated with choriocarcinoma?
Which of the following markers is associated with choriocarcinoma?
How is the presence of pheochromocytoma indicated?
How is the presence of pheochromocytoma indicated?
Which marker is linked to breast cancer?
Which marker is linked to breast cancer?
Which biomarker is associated with acute myelocytic leukemia?
Which biomarker is associated with acute myelocytic leukemia?
What characterizes a malignant neoplasm?
What characterizes a malignant neoplasm?
What causes cancer at the cellular level?
What causes cancer at the cellular level?
Which of the following does NOT typically apply to benign neoplasms?
Which of the following does NOT typically apply to benign neoplasms?
Which of the following is an indication of an immune response to a tumor?
Which of the following is an indication of an immune response to a tumor?
What does the term 'anaplasia' refer to in tumor biology?
What does the term 'anaplasia' refer to in tumor biology?
Which type of neoplasm is likely to cause death due to its invasive nature?
Which type of neoplasm is likely to cause death due to its invasive nature?
What is the definition of a tumor in the context of tumor biology?
What is the definition of a tumor in the context of tumor biology?
What evidence supports the immune response against tumors?
What evidence supports the immune response against tumors?
What is the primary role of immunosurveillance in the immune system?
What is the primary role of immunosurveillance in the immune system?
Which cells are considered part of the innate immune defenses against tumors?
Which cells are considered part of the innate immune defenses against tumors?
What characterizes active immunotherapy?
What characterizes active immunotherapy?
What is an example of passive immunotherapy?
What is an example of passive immunotherapy?
What do monoclonal antibodies specifically target in passive immunotherapy?
What do monoclonal antibodies specifically target in passive immunotherapy?
Which of the following best describes cytokines in the context of immunotherapy?
Which of the following best describes cytokines in the context of immunotherapy?
Which type of immunotherapy includes cancer vaccines?
Which type of immunotherapy includes cancer vaccines?
Coley’s toxins and BCG are examples of what type of immunotherapy?
Coley’s toxins and BCG are examples of what type of immunotherapy?
What can cause false positives in serum tumor marker detection?
What can cause false positives in serum tumor marker detection?
Which type of immunotherapy involves the infusion of tumor-infiltrating lymphocytes (TILs)?
Which type of immunotherapy involves the infusion of tumor-infiltrating lymphocytes (TILs)?
What type of relationship is characterized by both host and microbes benefiting each other?
What type of relationship is characterized by both host and microbes benefiting each other?
What is a key feature of automated immunoassays for detecting serum tumor markers?
What is a key feature of automated immunoassays for detecting serum tumor markers?
Which of the following is NOT a form of immunotherapy?
Which of the following is NOT a form of immunotherapy?
What is a characteristic of a commensalistic relationship between host and microbes?
What is a characteristic of a commensalistic relationship between host and microbes?
Which of these bacteria is commonly associated with virulence factors related to gastric ulcers?
Which of these bacteria is commonly associated with virulence factors related to gastric ulcers?
What type of relationship involves host and microbes coexisting without long-term benefits or harms?
What type of relationship involves host and microbes coexisting without long-term benefits or harms?
What is the significant titer for the Widal test indicating a strong possibility of typhoid fever?
What is the significant titer for the Widal test indicating a strong possibility of typhoid fever?
What type of antibodies does the Typhidot test detect for recent and remote infections?
What type of antibodies does the Typhidot test detect for recent and remote infections?
What is a primary limitation of the Typhidot test?
What is a primary limitation of the Typhidot test?
Which antigen is associated with active or current infections in the Widal test?
Which antigen is associated with active or current infections in the Widal test?
What do a positive IgM result from the Typhidot test indicate?
What do a positive IgM result from the Typhidot test indicate?
For what type of fever is the combination of O and A or B antigens significant?
For what type of fever is the combination of O and A or B antigens significant?
Which antigen is characterized as a somatic antigen in Salmonella paratyphi?
Which antigen is characterized as a somatic antigen in Salmonella paratyphi?
What does the Weil-Felix test specifically diagnose?
What does the Weil-Felix test specifically diagnose?
What type of bacterium is Helicobacter pylori?
What type of bacterium is Helicobacter pylori?
Which method is NOT commonly used to diagnose H. pylori infection?
Which method is NOT commonly used to diagnose H. pylori infection?
Which of the following is a characteristic of Mycoplasma pneumoniae?
Which of the following is a characteristic of Mycoplasma pneumoniae?
What is the gold standard for diagnosing Rocky Mountain Spotted Fever (RMSF)?
What is the gold standard for diagnosing Rocky Mountain Spotted Fever (RMSF)?
What type of infections are mainly caused by Mycoplasma pneumoniae?
What type of infections are mainly caused by Mycoplasma pneumoniae?
What is a common complication of untreated H. pylori infection?
What is a common complication of untreated H. pylori infection?
What type of bacteria are Rickettsia?
What type of bacteria are Rickettsia?
Which of the following is NOT a method to detect Mycoplasma pneumoniae infection?
Which of the following is NOT a method to detect Mycoplasma pneumoniae infection?
Flashcards
Neoplasm
Neoplasm
New growth of cells that doesn't normally induce tissue multiplication.
Benign Neoplasm
Benign Neoplasm
Slow-growing, localized tumor, not usually fatal.
Malignant Neoplasm
Malignant Neoplasm
Rapid or slow-growing tumor with spread and potential to cause death.
Cancer
Cancer
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Tumor
Tumor
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Tumor Biology
Tumor Biology
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Tumor Antigen
Tumor Antigen
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Immune Response Evidence (Tumors)
Immune Response Evidence (Tumors)
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Chromogranin A
Chromogranin A
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CYFRA 21-1
CYFRA 21-1
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DHEA
DHEA
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Metanephrines
Metanephrines
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Neuron-specific enolase
Neuron-specific enolase
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PNP
PNP
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Ferritin
Ferritin
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HCG (intact mol)
HCG (intact mol)
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Immunosurveillance
Immunosurveillance
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Innate Defenses Against Tumors
Innate Defenses Against Tumors
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Adaptive Immune Responses Against Tumors
Adaptive Immune Responses Against Tumors
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Immunotherapy for Cancer
Immunotherapy for Cancer
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Active Immunotherapy
Active Immunotherapy
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Passive Immunotherapy
Passive Immunotherapy
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Monoclonal Antibodies in Cancer Therapy
Monoclonal Antibodies in Cancer Therapy
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Cytokines in Cancer Therapy
Cytokines in Cancer Therapy
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Widal Test
Widal Test
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O Antigen
O Antigen
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H Antigen
H Antigen
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Significant Titer
Significant Titer
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A or B Antigen
A or B Antigen
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O and A or B
O and A or B
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Typhidot Test
Typhidot Test
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50Kd OMP Antigen
50Kd OMP Antigen
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Host-microbe Relationship
Host-microbe Relationship
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Indigenous Microbiota
Indigenous Microbiota
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Bacterial Virulence Factors
Bacterial Virulence Factors
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Immune Defenses Against Bacteria
Immune Defenses Against Bacteria
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Bacterial Infection Detection
Bacterial Infection Detection
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Group A Streptococci
Group A Streptococci
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Helicobacter Pylori
Helicobacter Pylori
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Mycoplasma Pneumoniae
Mycoplasma Pneumoniae
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H. pylori Infection
H. pylori Infection
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H. pylori Diagnosis
H. pylori Diagnosis
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M. pneumoniae Infection
M. pneumoniae Infection
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M. pneumoniae Detection
M. pneumoniae Detection
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Rickettsia (RMSF and Typhus)
Rickettsia (RMSF and Typhus)
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Rickettsia Diagnosis
Rickettsia Diagnosis
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Syphilis
Syphilis
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Lyme Disease
Lyme Disease
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Study Notes
Immunodeficiency Diseases
- Primary immunodeficiencies (PIDs) are inherited while secondary immunodeficiencies are acquired.
- PIDs result from missing or dysfunctional immune system components.
- PIDs make individuals more susceptible to infections and cancer.
- Several immune system components can be affected by PIDs including humoral immunity, cell-mediated immunity and innate immunity.
- Humoral immunodeficiencies are caused by defects in B cells or Th cells.
- Cell-mediated immunodeficiencies involve T-cell deficiencies.
- Innate immunodeficiencies involve neutrophils or macrophages, or complement.
- Nine categories of PIDs: Combined immunodeficiencies, combined immunodeficiencies with associated or syndromic features, predominantly antibody deficiencies, diseases of immune dysregulation, congenital defects of phagocytes, defects in innate immunity, autoinflammatory disorders, complement deficiencies, and phenocopies of primary immunodeficiencies.
- Several types and causes of PID are mentioned, including X-linked, autosomal recessive, and autosomal dominant inheritance.
- Some disorders, like X-linked severe combined immunodeficiency (XSCID), are caused by mutations in specific genes, such as the IL2RG gene.
- Many types of laboratory tests can be used to diagnose PIDs, including flow cytometry to assess white blood cell (WBC) counts and types.
- Laboratory detection of primary immunodeficiencies is done through various tests.
Tumor Immunology
- Tumor biology encompasses the properties of a tumor, including malignant properties, uncontrolled cell division, and the ability to resist apoptosis.
- Tumor cells often evade normal immune defenses and can form a mass, causing swelling.
- Tumor antigens are proteins or enzymes unique to tumors.
- Clinically relevant tumor markers are biological substances found in elevated amounts in bodily fluids or tissues for certain cancers.
- Laboratory tests for tumors such as immunohistochemistry, immunoassays, molecular methods, and proteomics can detect antigens.
- Immunosurveillance refers to the immune system's role in recognizing and destroying tumor cells.
- Examples of tumor markers include AFP, CA 125, and CEA.
- Several types of immunotherapies, including active, passive, and adoptive, exist for the treatment of cancer.
- Active immunotherapy stimulates the patient's immune system.
- Passive immunotherapy administers soluble components of the immune system.
- Adoptive immunotherapy involves transferring immune cells to patients.
Serologic and Molecular Detection of Certain Bacterial Infections
- Host-microbe relationships involve symbiosis, commensalism, mutualism, and parasitism.
- Bacterial infectivity is the organism's ability to establish an infection.
- Bacterial pathogenicity is the ability of an organism to cause disease.
- Bacterial virulence describes the extent of the pathology caused by an organism.
- Structures of bacteria include cell wall, cytoplasm membrane, capsule, pili, plasmids, and flagellum.
- Virulence factors of bacteria include endotoxins and exotoxins (toxins released from live bacteria).
- Immune defenses against bacteria include innate defenses (skin, mucosal surfaces, antimicrobial peptides, complement proteins) and adaptive defenses (antibodies, cell-mediated immunity).
- Laboratory detection of bacterial infections includes culture, microscopic examination, detection of bacterial antigens, and molecular detection techniques.
- Various clinical manifestations are associated with specific bacterial infections, and laboratory tests are used to detect and diagnose those infections.
- Group A streptococcal infections, Helicobacter pylori infections, Mycoplasma pneumoniae infections, rickettsial infections, and certain serologic tests are highlighted, including ASO, anti-DNase, and Widals tests.
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