L12 Limbic System
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Questions and Answers

What is the role of the limbic system in connection to the sense of smell?

  • It integrates sensory information mainly for visual processing.
  • It is primarily responsible for motor functions.
  • It is closely associated with emotion and memory. (correct)
  • It regulates the endocrine system.
  • Which component of the limbic system is NOT mentioned as part of the allocortex?

  • Dentate Gyrus
  • Primary Olfactory Cortex
  • Cingulate Gyrus (correct)
  • Hippocampus Proper
  • What term describes the old name for the limbic system, reflecting its association with the sense of smell?

  • Limbicus Cortex
  • Lobulus Rhinencephalicus
  • Rhinencephalon (correct)
  • Cortex Olfactoria
  • Which structure is part of the neocortex as categorized in the limbic system?

    <p>Entorhinal Cortex (B)</p> Signup and view all the answers

    What does the term 'limbic' derive from, indicating its anatomical positioning?

    <p>It signifies being a 'border' around the diencephalon. (B)</p> Signup and view all the answers

    What is the current term for Broca's 'callosal gyrus'?

    <p>Cingulate gyrus (D)</p> Signup and view all the answers

    Which of the following is NOT a function associated with the Limbic System?

    <p>Controlling motor skills (D)</p> Signup and view all the answers

    What type of affects evolved in early vertebrates?

    <p>Defensive and appetitive affects (A)</p> Signup and view all the answers

    Which of the following statements is true regarding the c-shaped structures of the Limbic System?

    <p>They form anatomical and logical loops. (C)</p> Signup and view all the answers

    What is suggested about the cyclic networks of excitation/inhibition in the brain?

    <p>They can be exaggerated or abbreviated by later evolved brain structures. (B)</p> Signup and view all the answers

    Which statement best describes the evolutionary development of parental emotions?

    <p>They appeared in early mammals and independently in other species like birds and dinosaurs. (A)</p> Signup and view all the answers

    Which function of the Limbic System is least related to higher functions?

    <p>Controlling basic motor skills (A)</p> Signup and view all the answers

    What is significant about the affects evolved in animals according to the provided content?

    <p>Different affects evolved at different times and for different purposes. (C)</p> Signup and view all the answers

    What is the primary function of the basolateral nuclei of the amygdala?

    <p>Associating stimuli with primary reinforcement value (A)</p> Signup and view all the answers

    Which nuclei of the amygdala receives olfactory input?

    <p>Corticomedial Nuclei (B)</p> Signup and view all the answers

    Which statement about the central nuclei of the amygdala is true?

    <p>They receive input from brainstem visceral nuclei. (D)</p> Signup and view all the answers

    In the context of Korsakoff Syndrome, which brain structure is specifically mentioned as related to the syndrome?

    <p>Dorsomedial thalamic nucleus (B)</p> Signup and view all the answers

    What is the primary input that the corticomedial nuclei of the amygdala receive?

    <p>Olfactory input from lateral stria (A)</p> Signup and view all the answers

    Which statement accurately describes the James-Lange Theory of Emotion?

    <p>Subjective experience of emotion follows the detection of physiological state. (D)</p> Signup and view all the answers

    What is a significant characteristic of the Limbic System concerning emotions?

    <p>It is primarily a motor system with no sensory processing for emotions. (A)</p> Signup and view all the answers

    How does Emotional Field Theory quantify emotional states?

    <p>Using multidimensional scaling to describe arousal and valiance. (B)</p> Signup and view all the answers

    What role do monoamine neurotransmitters play in the brainstem's diffuse modulating systems?

    <p>They act as broadcast signals in widely distributed neuron networks. (C)</p> Signup and view all the answers

    What does the Lövheim Cube of Emotions correlate with?

    <p>The activity of monoamine neurotransmitters in the central nervous system. (B)</p> Signup and view all the answers

    Which aspect of emotional expression does the content suggest is influenced by social interactions?

    <p>Emotions are at least partly acquired through the imitation of others. (B)</p> Signup and view all the answers

    How is emotional arousal typically recorded, as per the discussed theories?

    <p>Through skin conductance and startle response measurements. (A)</p> Signup and view all the answers

    What is the functional significance of the groups of neurons in the brainstem reticular formation?

    <p>They form diffuse modulating systems linked to monoamine neurotransmitters. (D)</p> Signup and view all the answers

    What is the name of the hippocampal formation's primary part that is associated with the dentate gyrus?

    <p>Parvocellular (D)</p> Signup and view all the answers

    Which structure of the hippocampal formation is considered to be particularly vulnerable to ischemia?

    <p>CA1&amp;2 (B)</p> Signup and view all the answers

    What is the developmental origin of the hippocampus?

    <p>Modified sulcus (A)</p> Signup and view all the answers

    What effect does a bilateral lesion of the hippocampus most likely induce?

    <p>Anterograde amnesia (A)</p> Signup and view all the answers

    What anatomical term refers to the 'Cornu Ammonis' in relation to the hippocampus?

    <p>Hippocampus Proper (A)</p> Signup and view all the answers

    What does the term 'Hippocampus' literally translate to?

    <p>Seahorse (C)</p> Signup and view all the answers

    What function is the subiculum primarily associated with in the hippocampal formation?

    <p>Support (C)</p> Signup and view all the answers

    Which part of the hippocampal formation is identified as a migration of the medial pallium during development?

    <p>Hippocampus Proper (C)</p> Signup and view all the answers

    What is the role of the septal nuclei in the brain's reward pathway?

    <p>They stimulate behaviors that lead to reinforcement. (B)</p> Signup and view all the answers

    Which brain structure is included in the septal region?

    <p>Subcallosal area (D)</p> Signup and view all the answers

    What behavior do mice exhibit when exposed to artificial stimulation of the septal nuclei?

    <p>They seek out the stimulation over other rewards. (A)</p> Signup and view all the answers

    Which structure is part of the medial forebrain bundle?

    <p>Septal nuclei (C)</p> Signup and view all the answers

    What defines the 'septal loop' in the brain's architecture?

    <p>A network of nuclei that reinforces goal-oriented behaviors. (B)</p> Signup and view all the answers

    Which of the following best describes the relationship between rewarding sensory experiences and emotions?

    <p>Goal-oriented experiences contribute significantly to emotional responses. (D)</p> Signup and view all the answers

    In which area of the brain do the fibers of the medial forebrain bundle primarily run?

    <p>Lateral hypothalamic nuclei (A)</p> Signup and view all the answers

    What indicates that the septal nuclei are crucial for behavior reinforcement?

    <p>Experiments show preference over basic needs. (B)</p> Signup and view all the answers

    Which function is NOT associated with the septal region?

    <p>Initiating reflexive motor actions. (A)</p> Signup and view all the answers

    What is one of the main functions of Plutchik's Wheel of Emotion?

    <p>It identifies high and low intensity forms of basic emotions. (B)</p> Signup and view all the answers

    Which of the following is a culturally specific emotion mentioned in the content?

    <p>Gezelligheid (A)</p> Signup and view all the answers

    What does the term 'Ilinx' refer to according to the content?

    <p>A state of ecstatic dread or panic. (D)</p> Signup and view all the answers

    Which emotion reflects the feeling of wanting to visit a distant land?

    <p>Kaukokaipu (B)</p> Signup and view all the answers

    How many basic emotions are identified in Plutchik's Wheel of Emotion?

    <p>8 (C)</p> Signup and view all the answers

    What basic feeling does Awumbuk convey?

    <p>The sense of loss when visitors leave. (B)</p> Signup and view all the answers

    What aspect of emotional expression is noted to be universal across cultures?

    <p>Facial expressions corresponding to basic emotions. (A)</p> Signup and view all the answers

    Which emotion represents pity felt for someone in need, which also includes an anticipation of loss?

    <p>Fago (C)</p> Signup and view all the answers

    What is a primary characteristic that distinguishes emotions from reflexes?

    <p>Emotions usually last longer than the stimuli that evoke them. (B)</p> Signup and view all the answers

    How do social emotions such as guilt and jealousy evolve in mammals?

    <p>They initially served individual adaptive functions and later gained social importance. (A)</p> Signup and view all the answers

    In what way do emotions influence learning and behavior according to the discussed concepts?

    <p>They help organisms to remember and adjust behavior based on experiences. (A)</p> Signup and view all the answers

    What role does the limbic system primarily play in relation to emotional responses?

    <p>It prioritizes long-term goal setting and motivations. (A)</p> Signup and view all the answers

    Which physiological response is typically associated with different emotions?

    <p>Autonomic responses that allow for nuanced metabolic control. (D)</p> Signup and view all the answers

    What implication does the association between intense emotions and the sense of smell have?

    <p>It highlights a direct link between olfactory triggers and emotional memories or conditions. (D)</p> Signup and view all the answers

    Which of the following statements about higher functions and emotions is accurate?

    <p>When higher functions falter, behaviors driven by emotions may take precedence. (C)</p> Signup and view all the answers

    Which statement best explains the evolution of emotions in mammals living in groups?

    <p>Emotions gained social and symbolic functions over time in social animals. (A)</p> Signup and view all the answers

    What is a characteristic symptom of Klüver-Bucy syndrome?

    <p>Hypersexuality with no gender preference (D)</p> Signup and view all the answers

    Which of the following is NOT a common characteristic of Klüver-Bucy syndrome?

    <p>Extreme aggression (A)</p> Signup and view all the answers

    What condition is associated with partial Klüver-Bucy syndrome?

    <p>Herpes simplex encephalitis (B)</p> Signup and view all the answers

    Which brain structure is primarily affected in Klüver-Bucy syndrome?

    <p>Amygdala (B)</p> Signup and view all the answers

    What aspect of behavior is significantly altered in Klüver-Bucy syndrome?

    <p>Unusual sexual behaviors (A)</p> Signup and view all the answers

    What is the term used to describe the unrealistic portrayal of Klüver-Bucy syndrome in popular media?

    <p>Misrepresentation (A)</p> Signup and view all the answers

    Which of the following features best corresponds with the symptom of being overly attentive to sensory stimuli in Klüver-Bucy syndrome?

    <p>Hyperesthesia (B)</p> Signup and view all the answers

    What is the primary emotion affected by Klüver-Bucy syndrome?

    <p>Fear (B)</p> Signup and view all the answers

    What is a key function of the Papez circuit in the brain?

    <p>Transferring short term memory to long term memory (A)</p> Signup and view all the answers

    Which vitamin deficiency is primarily responsible for Wernicke's Syndrome?

    <p>Thiamine (Vitamin B1) (D)</p> Signup and view all the answers

    What are the main symptoms represented by the acronym COAT in Wernicke's Encephalopathy?

    <p>Confusion, Opthalmoplegia, Ataxia, Thiamine Deficiency (B)</p> Signup and view all the answers

    Which of the following is a characteristic of Korsakoff's syndrome?

    <p>Retrograde Amnesia (C)</p> Signup and view all the answers

    What physical changes occur in the brain due to Wernicke's syndrome?

    <p>Degeneration of mammillary bodies (B)</p> Signup and view all the answers

    What component of the Papez circuit is directly affected by thiamine deficiency in Wernicke's encephalopathy?

    <p>Mammillary Bodies (D)</p> Signup and view all the answers

    What does the acronym RACK in Korsakoff's syndrome stand for?

    <p>Retrograde Amnesia, Anterograde Amnesia, Confabulation, Korsakoff’s (D)</p> Signup and view all the answers

    Which of the following best describes the relationship between high blood cortisol and studying ability?

    <p>It impairs the ability to study effectively. (C)</p> Signup and view all the answers

    What is the primary role of the amygdala in relation to sensory modalities?

    <p>It generates learned emotional responses. (D)</p> Signup and view all the answers

    Which pathway is involved in initiating visceral responses from the amygdala?

    <p>Ventral Amygdalofugal Pathway (A)</p> Signup and view all the answers

    How does the amygdala differ in its projection to the cortex compared to the thalamus?

    <p>It projects directly to the cortex without thalamic relay. (D)</p> Signup and view all the answers

    Which structure is located anterior to the amygdala?

    <p>Hippocampus (D)</p> Signup and view all the answers

    What is a consequence of bilateral destruction of the amygdalae?

    <p>Development of Klüver-Bucy syndrome (B)</p> Signup and view all the answers

    In terms of emotional processing, what role do projections to the hypothalamus play?

    <p>They initiate visceral responses to regulate emotions. (C)</p> Signup and view all the answers

    Which part of the amygdala integrates olfactory input?

    <p>Corticomedial Nuclei (B)</p> Signup and view all the answers

    What anatomical relationship is highlighted when discussing the placement of the amygdala?

    <p>It is anterior to the hippocampus. (A)</p> Signup and view all the answers

    What happens to cats with only the hypothalamus and brainstem intact in regard to emotional responses?

    <p>They display emotional responses like rage and fear to various stimuli. (B)</p> Signup and view all the answers

    Which term describes the interconnected group of structures in the forebrain that influences emotional behavior?

    <p>Limbic system (C)</p> Signup and view all the answers

    What does the limbic system primarily select or reject?

    <p>Emotional behaviors based on moment-to-moment stimuli (B)</p> Signup and view all the answers

    Which forebrain structure is associated with regulating emotional responses, alongside the hypothalamus?

    <p>Limbic lobe (A)</p> Signup and view all the answers

    Which structure is located deep within the brain and is crucial for memory formation?

    <p>Hippocampal formation (B)</p> Signup and view all the answers

    What characteristic differentiates the telencephalon from other parts of the brain?

    <p>It has larger and more interconnected neuron populations. (C)</p> Signup and view all the answers

    What is the primary role of the mammillary bodies within the limbic system?

    <p>Consolidating memory and emotional responses (C)</p> Signup and view all the answers

    What is the functional significance of the fornix in the brain?

    <p>Connects hippocampus to the septal area (A)</p> Signup and view all the answers

    Which structure can be found within the floor of the temporal horn of the lateral ventricle?

    <p>Hippocampal formation (B)</p> Signup and view all the answers

    What can be inferred about the interactions among structures in the limbic system?

    <p>They compete for control of lower brain centers. (D)</p> Signup and view all the answers

    Which of the following is true about the caudate nucleus?

    <p>It is associated with voluntary motor functions. (C)</p> Signup and view all the answers

    Which component is identified as the primary group of structures for new neuron formation in adult brains?

    <p>Hippocampal formation (A)</p> Signup and view all the answers

    What anatomical structure is often referred to as 'Napoleon’s Hat' in coronal section?

    <p>Lateral geniculate nucleus (B)</p> Signup and view all the answers

    What concept describes the limbic system's selection process for emotional responses?

    <p>Dynamic control of emotional outputs based on various factors (A)</p> Signup and view all the answers

    What role do the basolateral nuclei of the amygdala play in reinforcement learning?

    <p>They associate stimuli with reinforcement value. (C)</p> Signup and view all the answers

    Which structure is identified as giving rise to the stria terminalis?

    <p>Central nuclei (C)</p> Signup and view all the answers

    Which aspect of the corticomedial nuclei of the amygdala relates specifically to olfactory processing?

    <p>They are part of the primary olfactory cortex. (B)</p> Signup and view all the answers

    Which nuclei of the amygdala is responsible for receiving input from brainstem visceral nuclei?

    <p>Central nuclei (A)</p> Signup and view all the answers

    Which of the following accurately describes the layers found in the allocortex?

    <p>It is composed of 3-6 layers, primarily involved in olfactory functions. (A)</p> Signup and view all the answers

    What anatomical shape does the term 'amygdala' derive from, and what does it signify?

    <p>Almond, referencing its physical appearance. (B)</p> Signup and view all the answers

    Which of the following structures is NOT part of the limbic system loop as commonly categorized?

    <p>Globus Pallidus (B)</p> Signup and view all the answers

    What does the term 'rhinencephalon' historically refer to within the context of the limbic system?

    <p>Only the olfactory structures associated with the limbic system. (D)</p> Signup and view all the answers

    Which area of the limbic system is primarily linked to the regulation of memory and emotion, particularly in relation to the hippocampus?

    <p>Subiculum (A)</p> Signup and view all the answers

    In the context of the limbic system, what is the primary role of the cingulate gyrus?

    <p>To integrate emotional experiences with cognitive functions. (D)</p> Signup and view all the answers

    Which component of the hippocampal formation is specifically known as Sommer’s Sector?

    <p>Hippocampus Proper (C)</p> Signup and view all the answers

    What does the term 'Cornu Ammonis' refer to in the context of the hippocampal formation?

    <p>Hippocampus Proper (A)</p> Signup and view all the answers

    What is the developmental origin of the hippocampus described in the content?

    <p>Modified sulcus (B)</p> Signup and view all the answers

    Which part of the hippocampal formation is described as performing the role of 'support'?

    <p>Subiculum (C)</p> Signup and view all the answers

    What neurological condition is most likely to be caused by a bilateral lesion of the hippocampus?

    <p>Anterograde amnesia (A)</p> Signup and view all the answers

    Which aspect of the hippocampal formation is associated with the migration of the medial pallium during development?

    <p>Subiculum (B)</p> Signup and view all the answers

    What is the significance of ischemia in relation to the hippocampus?

    <p>It highlights the vulnerability of specific sectors. (A)</p> Signup and view all the answers

    What is the anatomical translation of 'Hippocampus'?

    <p>Sea horse (C)</p> Signup and view all the answers

    What is the primary role of emotions in relation to long-term planning and motivation?

    <p>Emotions set goals and determine what is memorable and learnable. (A)</p> Signup and view all the answers

    How did social emotions likely evolve in mammals that live in large groups?

    <p>They started with individual adaptive functions before gaining social significance. (C)</p> Signup and view all the answers

    What distinguishes emotions from reflexes in terms of duration?

    <p>Emotions are usually longer-lasting than the stimuli that elicit them. (B)</p> Signup and view all the answers

    Which entities are primarily responsible for autonomic responses linked to emotions?

    <p>The autonomic nervous system and neuroendocrine systems. (A)</p> Signup and view all the answers

    In what way do emotions influence behavior according to the provided content?

    <p>Emotions can make various types of behaviors more or less likely. (C)</p> Signup and view all the answers

    What specific association is noted between emotions and the sense of smell?

    <p>Strong emotions, especially social ones, are linked to specific odors. (C)</p> Signup and view all the answers

    What is a key difference between sympathetic and parasympathetic responses to emotions?

    <p>Sympathetic responses use up metabolic reserves, while parasympathetic responses help accumulate them. (D)</p> Signup and view all the answers

    What significant role do emotions play in adjusting behaviors based on past experiences?

    <p>Emotions enable organisms to alter behavior based on long past experiences. (D)</p> Signup and view all the answers

    What structures can typically form anatomical and logical loops in the limbic system?

    <p>C-shaped structures (A)</p> Signup and view all the answers

    Which aspect of the limbic system is primarily related to planning and decision making?

    <p>Regulation of mood and higher functions (A)</p> Signup and view all the answers

    Which type of emotions evolved in early mammals as described in the content?

    <p>Sub-social parental emotions (C)</p> Signup and view all the answers

    Which brain structures are suggested to exaggerate or abbreviate cyclic networks of excitation/inhibition?

    <p>Evolved brain structures (D)</p> Signup and view all the answers

    What is one of the main functions associated with the limbic system?

    <p>Higher cognitive functions (B)</p> Signup and view all the answers

    What distinguishes the early vertebrate affects from those evolved later in mammals?

    <p>Defensive and appetitive purposes (A)</p> Signup and view all the answers

    Which feature of the limbic system contributes to the production of diverse behaviors?

    <p>Cyclic loops of excitation and inhibition (B)</p> Signup and view all the answers

    Which statement best summarizes the nature of emotions as developed in various vertebrate species?

    <p>Emotions evolved for unique purposes at different times. (C)</p> Signup and view all the answers

    What are the symptoms classified under Wernicke's Encephalopathy?

    <p>Confusion, Ophthalmoplegia, Ataxia, Thiamine Deficiency (A)</p> Signup and view all the answers

    What is the primary function of the Papez circuit in the brain?

    <p>Consolidating memory and learning (D)</p> Signup and view all the answers

    What consequence does untreated Wernicke's Encephalopathy have?

    <p>Permanent Korsakoff syndrome (D)</p> Signup and view all the answers

    Which structure is primarily affected in the progress from Wernicke's Encephalopathy to Korsakoff syndrome?

    <p>Mammillary bodies (C)</p> Signup and view all the answers

    Which symptom is associated with Korsakoff's syndrome?

    <p>Retrograde Amnesia (A)</p> Signup and view all the answers

    What vitamin deficiency is primarily associated with Wernicke's Syndrome?

    <p>Vitamin B1 (D)</p> Signup and view all the answers

    What does the acronym RACK represent in Korsakoff's syndrome?

    <p>Retrograde Amnesia, Ataxia, Confabulation, Korsakoff’s (D)</p> Signup and view all the answers

    How does alcohol impact thiamine levels in the body?

    <p>Dehydrates the body, reducing thiamine levels (B)</p> Signup and view all the answers

    Flashcards

    Rhinencephalon

    The name given to the old olfactory cortex in the brain. This area sits adjacent to the limbic system, which regulates emotions, memory, and behavior.

    Limbic System

    A ring of brain structures surrounding the diencephalon, primarily involved in emotion, motivation, and memory.

    Olfactory Cortex

    The area of the cortex responsible for our sense of smell.

    Hippocampus

    A region of the limbic system that plays a crucial role in memory formation, particularly spatial memory.

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    Monoaminergic Nuclei

    A group of neurons that release monoamines, neurotransmitters like dopamine, serotonin, and norepinephrine, which are involved in regulating moods, behaviors, and sleep.

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    Gray vs. White Matter

    Gray matter is made up of neuronal cell bodies and dendrites, while white matter is mainly comprised of myelinated axons.

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    "C" shaped structures in the limbic system

    Structures in the limbic system are often shaped like "C"s and form loops. These loops connect different brain areas involved in mood, memory, and decision-making.

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    Functions of the Limbic System

    The limbic system regulates mood and facilitates essential functions like memory formation, planning, and decision-making.

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    Cingulate Gyrus

    The cingulate gyrus, previously referred to as Broca's "callosal gyrus", is a C-shaped structure involved in emotional processing.

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    Evolution of Emotions

    Emotions are complex and evolved over time. Basic, survival-based emotions like fear and pleasure were present in early vertebrates.

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    Sub-social Parental Emotions

    Emotions like caring for offspring are more recently evolved and appeared independently in mammals and birds.

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    Cyclic Networks and Contingent Behavior

    Cyclic networks of excitation and inhibition within the brain can be modulated by higher brain structures, leading to more complex and adaptable behaviors.

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    Modern View of the Limbic System

    Our current understanding of the limbic system is that it forms a group of forebrain structures that regulate mood and facilitate "higher" functions.

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    James-Lange Theory of Emotion

    A theory suggesting that emotions are a result of our physiological responses to stimuli, rather than the other way around. When we encounter a situation, our body reacts with physical changes like increased heart rate or muscle tension, and it's our interpretation of these changes that leads to subjective emotional experience.

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    Emotional Field Theory

    This theory posits that emotional states are represented as points within a continuous space, rather than discrete categories. This space can be defined by dimensions like arousal (how intense the emotion is) and valence (how pleasant or unpleasant it is).

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    Lövheim's Cube of Emotions

    A three-dimensional model that describes emotions based on three axes: pleasure-displeasure, arousal-calm, and dominance-submission. Each point within the cube represents a unique emotional state.

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    Diffuse Modulating Systems

    Groups of neurons in the brainstem that release neurotransmitters with widespread effects throughout the brain. Each system is associated with a specific monoamine neurotransmitter like dopamine, norepinephrine, or serotonin.

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    Subjective experience of emotion

    The subjective experience of emotion is a result of perceiving our own physiological changes, such as increased heart rate or sweating, rather than the other way around.

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    Learning of Emotions

    Emotions are not entirely hard-wired, and are at least partly acquired through the imitation of others.

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    Limbic System and Emotion

    The limbic system does not have a dedicated sensory area for emotions. Instead, the subjective experience of emotion arises from interpreting physiological changes in the body.

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    Bilateral Transplantation of Gracilis Muscle

    The process of transplanting a gracilis muscle, typically taken from the thigh, and re-innervating it with the masseteric nerve. This procedure is used to restore facial mobility in individuals suffering from facial paralysis.

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    Septal Nuclei

    Part of the limbic system involved in reward, motivation, and pleasure. It's activated by rewarding experiences and stimuli.

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    Medial Forebrain Bundle (MFB)

    A large bundle of nerve fibers connecting the septal nuclei to other limbic structures, crucial for reward and motivation.

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    Septal Loop

    A circuit within the limbic system connecting the septal nuclei, amygdala, and brainstem reticular formation. This circuit plays a prominent role in regulating emotions.

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    Basolateral Nuclei of Amygdala

    A group of nuclei within the amygdala involved in processing emotional information and linking it with memory.

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    Brainstem Reticular Formation

    A part of the brainstem responsible for regulating arousal, sleep, and wakefulness, influencing emotional responses.

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    Habenular Nuclei

    A brain structure involved in processing sensory information and linking it to emotional responses.

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    Hippocampal formation

    The hippocampal formation is made up of three primary parts: the dentate gyrus, hippocampus proper, and the subiculum.

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    Dentate gyrus

    The dentate gyrus is a part of the hippocampal formation responsible for creating new neurons and integrating information.

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    Hippocampus proper

    The hippocampus proper is a major part of the hippocampal formation, crucial for forming new memories, especially long-term memories.

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    Subiculum

    The subiculum is a transition zone connecting the hippocampus to other brain areas, involved in memory retrieval and spatial navigation.

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    Hippocampus: Evolution

    The hippocampus is a C-shaped structure in the brain that evolved from the medial pallium.

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    Sommer's Sector

    Sommer's Sector, comprising CA1 and CA2 regions, is particularly prone to damage by reduced blood flow.

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    Bilateral hippocampal damage

    If both sides of the hippocampus are damaged, it can lead to anterograde amnesia, the inability to form new memories.

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    Hippocampus and memory

    The hippocampus is crucial for forming new memories, particularly about events, experiences, and places, and its damage can result in amnesia.

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    Amygdala

    The amygdala, meaning "almond" in Greek, is a brain structure shaped like an almond. It plays a key role in processing emotions, particularly fear and anxiety. It also helps in associating memories with emotions.

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    Corticomedial Nuclei

    The corticomedial nuclei are part of the primary olfactory cortex. They receive signals from the sense of smell and help process scents. Essentially, they are the brain's "smell center."

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    Central Nuclei

    The central nuclei of the amygdala receive input from various areas, including the brainstem and basolateral nuclei. They are responsible for sending signals to other parts of the brain, particularly the hypothalamus, triggering physical and emotional responses to fear and stress.

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    Basolateral Nuclei

    The basolateral nuclei are involved in associating neutral stimuli with emotions. This helps us learn to fear certain things, like the sound of a car horn associated with a near-miss accident.

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    Stria Terminalis

    The stria terminalis is a bundle of nerve fibers that connects the amygdala to other brain regions, like the hypothalamus. It plays a role in transmitting emotional signals, particularly those related to fear and anxiety.

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    Evolution of Social Emotions

    Emotions like guilt and jealousy emerged later in mammals that live in large social groups.

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    Emotions vs. Reflexes: Duration

    Emotions, unlike reflexes, often last beyond the duration of the stimulus that triggered them.

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    Emotions vs. Reflexes: Behavioral Influence

    Emotions don't dictate specific actions, but rather make certain behaviors more or less likely.

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    Emotions and Behavioral Priority

    Emotions, like reflexes, often take precedence over other behaviors, guiding goals and motivations in animals with long-term planning abilities.

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    Limbic System and Higher Brain Functions

    Higher brain functions, like planning and memory, are often directed by goals set by the limbic system, which is associated with emotions.

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    Smell and Emotions

    Emotions, especially intense or social ones, are strongly linked to the sense of smell, which can trigger strong emotional responses.

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    Sympathetic vs. Parasympathetic: Energy Use

    The sympathetic nervous system prepares the body for action, using up metabolic reserves, while the parasympathetic system conserves energy and helps the body recover.

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    Emotions and Autonomic Responses

    Different emotions are associated with distinct autonomic responses, suggesting that emotions may have evolved to fine-tune our physiological states.

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    Awumbuk

    This is the feeling of emptiness when visitors depart, often experienced in Papua New Guinea. It reflects the importance of social connection and the discomfort of separation.

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    Fago

    This feeling compels us to care for someone in need, but with a tinge of sadness due to the understanding that we'll eventually lose them. It's a bittersweet emotion common in the Caroline Islands.

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    Gezelligheid

    This is the feeling of being cozy and comfortable with close friends in a comfortable and warm environment. It's a uniquely Dutch feeling that emphasizes the importance of social warmth and belonging.

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    Ilinx

    This is the feeling of an intense but pleasurable panic, a kind of 'voluptuous panic'. It is often associated with risky or thrilling situations.

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    Papez Circuit

    A circuit in the brain that plays a critical role in memory formation, particularly transferring short-term memories to long-term storage. It involves the hippocampus, mammillary bodies, and other structures.

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    Wernicke's Encephalopathy

    A neurological condition caused by thiamine deficiency, often associated with alcoholism. Characterized by confusion, ophthalmoplegia (eye muscle paralysis), and ataxia (loss of coordination).

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    Korsakoff's Syndrome

    A severe neurological disorder that develops as a consequence of untreated Wernicke's Encephalopathy, characterized by amnesia, confabulation (making up memories), and ataxia.

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    Central Nuclei of the Amygdala

    Located within the amygdala, they receive input from various brain regions (including the basolateral nuclei) and are responsible for triggering emotional responses to fear and stress.

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    Basolateral Nuclei of the Amygdala

    A part of the amygdala involved in associating neutral stimuli with emotions, helping us learn to fear or dislike specific things.

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    What is the Amygdala?

    The amygdala is a small, almond-shaped structure located in the temporal lobe of the brain. It plays a crucial role in processing and experiencing emotions, especially fear and anxiety.

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    How does the amygdala work?

    The amygdala receives sensory information from various parts of the brain and helps us associate those sensory experiences with emotions. For example, if you see a snake, the amygdala helps you recognize the danger and experience fear.

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    How is the amygdala connected to other brain areas?

    The amygdala is interconnected with various brain areas, including the hippocampus (for memory), the hypothalamus (for controlling physiological responses), and the prefrontal cortex (for decision-making). This interconnectedness allows the amygdala to influence a wide range of emotional responses.

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    What happens if the amygdala is damaged?

    Damage to the amygdala can lead to a variety of emotional impairments. Individuals may lose the ability to experience fear or anxiety, have difficulty recognizing emotional expressions in others, and may be prone to making impulsive decisions.

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    What neurotransmitters does the amygdala use?

    The amygdala uses a variety of neurotransmitters, like dopamine and serotonin, to process and regulate emotions. These neurotransmitters are involved in motivation, reward, and mood, all of which contribute to how we experience and respond to emotions.

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    What is Klüver-Bucy syndrome?

    The Klüver-Bucy syndrome is a rare neurological disorder caused by bilateral damage to the amygdalae. It results in a variety of behavioral changes, including emotional blunting, hypersexuality, and a tendency to put objects in the mouth.

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    How does the amygdala influence our learning?

    The amygdala is involved in shaping our understanding of the world by associating memories with emotions. This allows us to learn from our experiences and adapt our behavior accordingly.

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    How is the amygdala important for survival?

    The amygdala plays a vital role in survival by triggering the fight-or-flight response, a physiological and behavioral adaptation to danger. This response is crucial for protecting us from threats and ensuring our safety.

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    Which brain structure is most affected in Klüver-Bucy syndrome?

    The amygdala, a brain structure crucial for processing emotions, particularly fear and anxiety, is often affected in patients with Klüver-Bucy syndrome.

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    What can cause Klüver-Bucy syndrome?

    Klüver-Bucy syndrome can result from several factors, including brain trauma, surgery, and infections such as herpes simplex encephalitis.

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    Is Klüver-Bucy syndrome common?

    Klüver-Bucy syndrome is not a common condition, and it is important to distinguish it from related but different neurological conditions.

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    Is the portrayal of Klüver-Bucy syndrome in "The World Is Not Enough" accurate?

    The portrayal of Klüver-Bucy syndrome in the James Bond movie "The World Is Not Enough" is inaccurate and unrealistic, as it exaggerates the behavioral characteristics of the condition.

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    Why are patients with Klüver-Bucy syndrome often described as docile?

    The "docile" and "calm" aspect of Klüver-Bucy syndrome arises from the absence of a fear response, which makes individuals less likely to react defensively.

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    What characterizes the hypersexuality in Klüver-Bucy syndrome?

    The hypersexuality present in Klüver-Bucy syndrome involves a lack of gender preference, meaning individuals may exhibit sexual interest towards both genders without discrimination.

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    How does heightened sensory awareness affect patients with Klüver-Bucy syndrome?

    The heightened sensory awareness in Klüver-Bucy syndrome can lead to individuals being easily distracted and overwhelmed by a variety of sensory stimuli.

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    Sham Rage

    The ability of cats with just their hypothalamus and brainstem intact to exhibit exaggerated anger or fear responses to almost any stimulus, lacking the ability to select and prioritize emotional responses based on current goals and past experience.

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    Hypothalamus

    The part of the brain responsible for basic biological functions like controlling body temperature, hunger, thirst, and sleep-wake cycles.

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    Brainstem

    The part of the brain that is involved in movement, coordination, and balance. It is connected to the cerebellum and helps control muscle movement and coordination.

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    What is the Limbic Loop?

    The "Limbic Loop" is a set of interconnected structures within the limbic system that play crucial roles in regulating emotions, motivation, and memory.

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    What's the Papez Circuit?

    The Papez circuit is a brain pathway involved in memory formation, particularly transferring memories from short-term to long-term storage. It includes the hippocampus, mammillary bodies, and other structures.

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    What is Amimia?

    Amimia is a condition involving the inability to perform voluntary movements, typically caused by lesions in specific areas of the limbic system.

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    What is Korsakoff's Syndrome?

    Korsakoff's Syndrome is a severe brain disorder that develops from untreated Wernicke's Encephalopathy, characterized by amnesia, confabulation (making up memories), and lack of coordination.

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    What is Wernicke's Encephalopathy?

    A neurological condition caused by thiamine deficiency, often associated with chronic alcoholism. It results in confusion, eye muscle paralysis (ophthalmoplegia), and loss of coordination (ataxia).

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    What are the Central Nuclei of the Amygdala?

    The part of the amygdala that receives input from various regions, including the basolateral nuclei. It plays a key role in triggering emotional responses to fear and stress.

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    What are the Basolateral Nuclei of the Amygdala?

    A part of the amygdala involved in associating neutral stimuli with emotions. It helps us learn to fear or dislike specific things.

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    Hippocampus: Evolutionary Origin

    The medial pallium, a part of the brain involved in memory and sensory integration, evolves into the hippocampus.

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    Social Emotions

    Emotions developed later in mammals that live in large groups, suggesting they likely evolved for social interactions.

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    Emotions vs. Reflexes

    Emotions are not simply reflexes. Unlike reflexes, they can last longer than the initial stimulus and influence a range of behaviors, not just one.

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    Limbic System & Higher Brain Functions

    The limbic system is involved in setting goals, while higher brain functions like planning and memory help us achieve those goals. It's like a team effort.

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    Sympathetic vs. Parasympathetic

    The sympathetic nervous system uses up energy for action, while the parasympathetic system conserves energy for recovery. Think of it like a gas pedal vs. a brake.

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    Emotions & Autonomic Responses

    Different emotions are associated with unique physiological changes, suggesting that emotions evolved to fine-tune our bodily responses.

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    Emotions Influence Learning

    Emotions are not just feelings; they also shape what we remember and learn, allowing us to adapt our behavior based on past experiences.

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    Emotions & Motivation

    Cortically derived motivations set goals, while emotions help us orient ourselves towards those goals. The limbic system is involved in the 'caring' aspect of these processes.

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    What is the Cingulate Gyrus?

    The cingulate gyrus, previously known as Broca's "callosal gyrus," is a C-shaped structure involved in processing emotions, particularly fear and anxiety.

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    What is the Limbic System?

    The limbic system is a group of forebrain structures that regulate mood and facilitate essential processes like memory formation, planning, and decision-making.

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    How did emotions evolve?

    Basic emotions like fear and pleasure appeared in early vertebrates, while more complex emotions like parental care evolved later in mammals and birds.

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    How do brain loops affect behavior?

    Cyclic networks of excitation and inhibition in the brain can be regulated by higher brain structures, resulting in more diverse and adaptable behaviors.

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    What are "C" shaped structures in the limbic system?

    The "C" shaped structures in the limbic system, like the cingulate gyrus and hippocampus, form loops that interconnect different brain areas involved in emotions, memory, and decision-making.

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    What is the difference between Gray and White matter?

    Gray matter consists of neuronal cell bodies and dendrites, while white matter primarily contains myelinated axons.

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    What is the modern view of the Limbic System?

    The current concept of the limbic system encompasses a group of forebrain structures that influence mood and facilitate "higher functions" like memory and planning.

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    What is the Hypothalamus?

    The hypothalamus, a key part of the brainstem, is responsible for regulating basic biological functions such as body temperature, hunger, thirst, and sleep-wake cycles.

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    Study Notes

    Limbic System Overview

    • DOSYS-725 MedNeuro II Lecture 12, Wednesday Jan 29 @ 9am, taught by Tony Harper, Ph.D.
    • The lecture focuses on the Limbic System.
    • Lecture objectives include understanding the locations of major monoaminergic nuclei in the brainstem, their effects on behavior and mood, and the connectivity of the grey and white matter tracts within the Limbic Loop, Septal loop,Papez Circuit, and the Amygdala.
    • The lecture also covers various emotional, behavioral Syndromes such as Amimia, Wernicke's Syndrome, Korsakoff's Syndrome, and Klüver-Bucy Syndrome.
    • Early works from Bard on the brain and emotion.
    • The Limbic System is a group of forebrain structures critical for regulating mood and memory, as well as planning, decision-making, and higher functions. It can be considered a complex network of interconnected structures, forming anatomical and 'logical' loops, and often involved in cyclical networks of excitation/inhibition.

    Limbic System Structures and Connectivity

    • Subpallium develops into structures like the striatum, globus pallidus.
    • Allocortex has less than 6 layers and includes Archicortex (3 layers) originating from the medial pallium (Dentate Gyrus, and Hippocampus) and Paleocortex (3-5 layers) originating from lateral and ventral pallium (Primary Olfactory Cortex, parahippocampal gyrus).
    • Juxtallocortex has 3-6 layers and includes the cingulate gyrus, Fasciolar Gyrus, Isthmus, and Subiculum.
    • Neocortex consists of 6 layers, likely partly from the dorsal pallium, and includes the entorhinal cortex, forming a large part of the cerebral cortex.
    • The Limbic system is a network of interconnected brain structures involved in emotion, memory, and motivation.
    • The Hippocampus is a modified sulcus developmentally.
    • The Hippocampal formation has three main parts: parvocellular, magnocellular, and subiculum, all forming connections through the hippocampus pathway and playing memory/consolidation roles.
    • The Hippocampus can be found deep to the posterior part of the parahippocampal gyrus.
    • The Limbic System includes a network of interconnecting areas, contributing to more complex and multifaceted behaviors.

    Emotional versus Reflexes

    • Emotions are different than reflexes (which are automatic responses) as they are not stimulus-dependent or short-duration.
    • Emotions can involve many behaviors, making their expression more or less likely, not just one action. Emotions tend to hold high priority to help set goals and motivate goals in animals capable of long-term planning.
    • Emotions evolved over time for diverse purposes, such as defensive aversive and appetitive responses that are part of earlier vertebrate development.
    • Emotions like social emotions (like guilt and jealousy) show evolutionary changes and appeared later in mammals that have evolved complex social structures.
    • Different types of emotions, including social ones which emerged later in mammals with complex social dynamics are essential for complex human behavior.

    Emotions vs. "Higher Functions"

    • Cortically developed motivations set goals while emotions orient the individual toward their goals (the limbic system can be regarded as "caring").
    • Emotions are key in determining the things that are memorable and learnable, and help to change behaviors in response to prior experiences.
    • Emotions and smells are tightly connected, as seen with triggers and strong associations (burning oil and PTSD flashbacks, etc.)
    • Emotions are also strongly associated with smell, which can serve as potent triggers.
    • Emotions are integral to the overall functioning of the brain and organism, influencing memory, decision-making, and various other behaviors.

    Sympathetic vs. Parasympathetic

    • Sympathetic and parasympathetic systems (involving the autonomic nervous system) exert opposing effects; one system is involved in expending energy reserves (sympathetic), the other in accumulating energy (parasympathetic).
    • The nervous system also reacts in a variety of responses to different emotions, helping to regulate neuroendocrine physiological states.
    • The autonomic nervous system actively responds to emotions.
    • The interplay between sympathetic and parasympathetic systems facilitates fine-tuning of physiological responses, supporting both energy expenditure and conservation.

    Emotional Field Theory

    • Emotions encompass multiple factors, not just arousal or valence.
    • Quantifying emotional states as variables (such as skin conductance and startle response) is useful for scientific purposes.

    Lövheim's Cube of Emotions

    • Emotions can be viewed through dimensions determined by specific extremes.
    • Various neurotransmitters correlate with different areas of emotion.

    Better Living through Chemistry (Neurotransmitters)

    • The reticular formation contains neurotransmitter-releasing neurons that form a diffuse modulating system, and these systems are responsible for widespread signaling in the brain and spinal cord.
    • These systems are extremely wide-ranging and use long axons, forming a network where neurotransmitters aid in signaling.
    • Neurotransmitters play a vital role in shaping emotional responses, impacting various aspects of brain function.

    Dopaminergic Pathways

    • Dopamine-producing neurons are located mainly in the midbrain.
    • These pathways are primarily mesostriatal (nigrostriatal), mesolimbic, mesocortical, and tuberoinfundibular.
    • Various parts of the brain control different functions through the release of dopamine.

    Nucleus Accumbens

    • Part of the ventral striatum
    • Involved in the reward pathway and influenced by dopamine, which is related to schizophrenia when it is not balanced.
    • A key part of the reward pathway, also involved in motivation.
    • The nucleus accumbens is a hub for rewarding and motivational behavior.

    Papez Circuit

    • Part of the limbic system, linking emotional experience to expression in the brain, and critical for memory consolidation.
    • The circuit connects sensory input to behavioral output.
    • The Papez circuit is now considered part of the larger limbic system and comprises structures such as the hippocampal formation, fornix, cingulate gyrus, and other areas. Detailed description of the pathway, including the structures and connections involved. Detailed descriptions, including the various connections and structures involved.

    Septal Area and Nuclei

    • The septal area and its nuclei are located deep within the brain's medial wall.
    • These structures are an essential part of the limbic system and play various roles related to rewards and motivation.
    • The septal area also plays a significant role in reward and motivational functions.

    Klüver-Bucy Syndrome

    • Results from bilateral destruction of the amygdala, characterizing with a reduction or absence of fear response, hypersexuality, and overly attentive behavior towards stimuli, including sensory ones.
    • The Klüver-Bucy syndrome underscores the amygdala's crucial function in regulating fear and emotional responses.

    Wernicke's Syndrome

    • A neurological condition related to thiamine deficiency (B1 vitamin), often associated with chronic alcohol abuse.
    • Wernicke's encephalopathy can lead to Korsakoff's syndrome when not treated, which affects memory formation and causes confabulation.
    • Common early manifestations of Wernicke's are noted (loss of reflexes, paresthesia, pain of muscles), but progression is noted as well (to coma or even death.
    • Wernicke's syndrome highlights the dependence of the nervous system on adequate nutritional support.

    Amygdala

    • Almond-shaped structure in the temporal lobe, a critical area involved in emotion, fear, and aggression.
    • Receives sensory information from various areas, and forms connections to the hypothalamus and other limbic structures.
    • Involved in emotional responses, memory processing, and learning, particularly those associated with potentially threatening situations.Detailed connections with other structures are noted.

    Amygdala Connections

    • Provides direct connections to cortex without relying on thalamic pathway.
    • Plays critical roles in immediate responses; receives sensory input, and projects to autonomic and sensorimotor areas.
    • The Amygdala has direct projections to hypothalamus, triggering visceral responses.
    • The amygdala connects to a variety of areas in both the medial and lateral systems.
    • The amgydala plays an essential role in emotional learning and memory, particularly in situations that evoke strong emotional responses.

    Hippocampus

    • Essential structure for learning and memory consolidation.
    • The hippocampus has a wide variety of connections that make it an important part of brain circuitry.
    • The hippocampus plays a critical role in various forms of memory consolidation.

    Bard's Experiments

    • Studies aimed to understand the role of forebrain (including the amygdala) in emotional responses.
    • Early work from Bard demonstrated that removal of the cerebral cortex allowed intact emotional reactions (sham rage).
    • The experiments of Bard highlighted the role of subcortical structures in emotional responses. Different subtypes of emotional responses, such as sham rage, that can be observed. Descriptions about the results, such as the observation of anger or fear in response to various types of stimuli, such as noxious stimuli or novel environmental stimuli.

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    Limbic System Lecture Notes PDF

    Description

    This quiz covers the intricacies of the limbic system, including its structure, function, and important brain pathways. Students will explore key components such as the amygdala and hippocampus while learning about limbic-related brain disorders. Prepare to identify locations and functions of these critical brain structures.

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