Podcast
Questions and Answers
Select true sentence about the Human Genome Project:
Select true sentence about the Human Genome Project:
When was the human nuclear genome fully sequenced?
When was the human nuclear genome fully sequenced?
Human chromatin is composed of:
Human chromatin is composed of:
Select a correct sentence on human genome
Select a correct sentence on human genome
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How long is human DNA in a single somatic cell?
How long is human DNA in a single somatic cell?
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The human genome is approximately 3 billion base pairs and contains about 20, 000 protein coding genes.
The human genome is approximately 3 billion base pairs and contains about 20, 000 protein coding genes.
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Nucleosomes are the structural and functional units of chromatin
Nucleosomes are the structural and functional units of chromatin
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The nuclear matrix mediates the formation of DNA loop domains that are anchored to S/MAR
The nuclear matrix mediates the formation of DNA loop domains that are anchored to S/MAR
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Interphase is a time in the cell cycle when the cell rests between mitosis and is transcriptionally inactive.
Interphase is a time in the cell cycle when the cell rests between mitosis and is transcriptionally inactive.
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Heterochromatin is condensed, transcriptionally inactive chromatin
Heterochromatin is condensed, transcriptionally inactive chromatin
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The terms heterochromatin and euchromatin refer to states of compaction and transcriptional potential.
The terms heterochromatin and euchromatin refer to states of compaction and transcriptional potential.
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The nucleosomes are separated by 10 to 90 bp stretches of histone H1 bound linker DNA.
The nucleosomes are separated by 10 to 90 bp stretches of histone H1 bound linker DNA.
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The human genome is organized into loop domains attached at their bases to the nuclear scaffold/matrix by S/MARs
The human genome is organized into loop domains attached at their bases to the nuclear scaffold/matrix by S/MARs
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Chromatin in the interphase nucleus are categorized into euchromatin and heterochromatin, based on the physical compaction state, gene density, and transcriptional activity
Chromatin in the interphase nucleus are categorized into euchromatin and heterochromatin, based on the physical compaction state, gene density, and transcriptional activity
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The structure of chromatin determines the accessibility of DNA to transcriptional machinery; thus, it is closely related to gene activity
The structure of chromatin determines the accessibility of DNA to transcriptional machinery; thus, it is closely related to gene activity
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Nucleosome is a structural unit of chromatin composed of a positively charged protein core of eight histone proteins wrapped by 1.7 turns of DNA 147 bp in length.
Nucleosome is a structural unit of chromatin composed of a positively charged protein core of eight histone proteins wrapped by 1.7 turns of DNA 147 bp in length.
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Metaphase chromosomes are so highly condensed that their morphology can be studied using the light microscope
Metaphase chromosomes are so highly condensed that their morphology can be studied using the light microscope
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Chromatin is just a passive platform for the storage of genetic information.
Chromatin is just a passive platform for the storage of genetic information.
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Dynamic mode of packing and unpacking chromatin is intimately linked to the ability of the genome to specifically complex with both histones and non-histone proteins
Dynamic mode of packing and unpacking chromatin is intimately linked to the ability of the genome to specifically complex with both histones and non-histone proteins
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As a first level of compaction, DNA segments of 147 bp are wrapped in 1.7 left-handed turns around histone octamers forming the nucleosome core, each having a diameter of 10-11 nm
As a first level of compaction, DNA segments of 147 bp are wrapped in 1.7 left-handed turns around histone octamers forming the nucleosome core, each having a diameter of 10-11 nm
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MicroRNAs are a family of small non-coding RNAs that regulate a wide array of biological processes including carcinogenesis
MicroRNAs are a family of small non-coding RNAs that regulate a wide array of biological processes including carcinogenesis
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S/MARs are DNA elements that serve to compartmentalize the chromatin into structural and functional domains
S/MARs are DNA elements that serve to compartmentalize the chromatin into structural and functional domains
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The nuclear matrix interacts with chromatin via specialized DNA sequences called S/MAR.
The nuclear matrix interacts with chromatin via specialized DNA sequences called S/MAR.
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Some of the S/MAR-binding proteins are dramatically deregulated in tumor cells
Some of the S/MAR-binding proteins are dramatically deregulated in tumor cells
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Anchorage of S/MARs to nuclear matrix is known to play a dual role.
(i) Structural role to maintain the higher order chromatin confirmation
(ii) functional role in regulation of DNA replication and gene expression.
Anchorage of S/MARs to nuclear matrix is known to play a dual role.
(i) Structural role to maintain the higher order chromatin confirmation
(ii) functional role in regulation of DNA replication and gene expression.
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There is currently only one model of chromatin organization.
There is currently only one model of chromatin organization.
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The nuclear matrix consists of both nuclear proteins and RNA
The nuclear matrix consists of both nuclear proteins and RNA
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The ultimate condensation that occurs during the formation of metaphase chromosomes during mitosis facilitates the faithful segregation of the genetic material into daughter cells.
The ultimate condensation that occurs during the formation of metaphase chromosomes during mitosis facilitates the faithful segregation of the genetic material into daughter cells.
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The main epigenetic mechanisms include DNA methylation, histone modifications, and regulation by non-coding RNAs
The main epigenetic mechanisms include DNA methylation, histone modifications, and regulation by non-coding RNAs
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Epigenetics refers to heritable and non-heritable traits without changing the DNA sequence
Epigenetics refers to heritable and non-heritable traits without changing the DNA sequence
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Epigenetic control operates on three major levels, i.e., on DNA, histones, and nucleosomes
Epigenetic control operates on three major levels, i.e., on DNA, histones, and nucleosomes
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MicroRNAs are endogenous, small non-coding RNAs that function in regulation of gene expression.
MicroRNAs are endogenous, small non-coding RNAs that function in regulation of gene expression.
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The epigenetic alteration is a well-known feature in human cancer.
The epigenetic alteration is a well-known feature in human cancer.
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MiRNA may function as either tumor suppressor or oncogene under certain circumstances.
MiRNA may function as either tumor suppressor or oncogene under certain circumstances.
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Circulating miRNAs are becoming candidates of emerging non-invasive cellular and molecular biomarkers of cancer.
Circulating miRNAs are becoming candidates of emerging non-invasive cellular and molecular biomarkers of cancer.
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The most commonly used staining system in pathomorphology is called H&E
The most commonly used staining system in pathomorphology is called H&E
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Hematoxylin stains cell nuclei red.
Hematoxylin stains cell nuclei red.
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