32 Questions
What is the enzyme responsible for the conversion of tyrosine to noradrenaline?
DOPA decarboxylase
How is dopamine actively packaged into vesicles?
By an amine transporter
What is the primary mechanism for the release of noradrenaline?
Classical Ca2+-mediated exocytosis
What is the primary mechanism for the termination of noradrenaline action?
Reuptake by a noradrenaline transporter
What is the primary enzyme responsible for the degradation of noradrenaline?
Monoamine oxidase and aldehyde dehydrogenase
Which receptor type functions as inhibitory receptors and autoreceptors reducing noradrenaline release?
Postsynaptic α2 adrenoceptors
Which physiological response is associated with noradrenaline at the cellular level?
CNS arousal
Which neurotransmitter deficiency is thought to underlie depression?
Noradrenaline & serotonin
What is the most established neurochemical theory underlying depression?
Monoamine theory
Which type of antidepressant drugs prevents the reuptake of serotonin and/or noradrenaline?
Monoamine reuptake inhibitors
What is the primary mechanism of action of monoamine reuptake inhibitors in the acute phase?
Block the reuptake of neurotransmitters
What adaptive changes in the brain are associated with chronic antidepressant treatment?
All of the above
Which neurotransmitter is thought to underlie depression?
Serotonin
Which enzyme is responsible for the degradation of serotonin?
Monoamine oxidase
What is the primary site of cells bodies for noradrenaline in the brain?
Locus ceruleus
Which receptor type is an inhibitory autoreceptor reducing serotonin release?
5-HT1A
What is the primary mechanism for the release of serotonin?
Ca2+-mediated exocytosis
Which enzyme is responsible for the conversion of tryptophan to serotonin?
Tryptophan hydroxylase
Which physiological response is associated with serotonin at the behavioral level?
Sleep, wakefulness, and mood
Which neurotransmitter is associated with cells bodies in the raphe nuclei?
Serotonin
Which of the following SSRIs is also an antagonist at 5-HT2C receptors?
Fluoxetine
What is a potential risk of SSRIs for children and adolescents under 18 years?
Potential risk of suicide ideation
What condition can SSRIs also be used to treat besides depression?
Premature ejaculation
Which side effect is NOT commonly associated with SSRIs?
Postural hypotension
Which of the following is a side effect of tricyclic antidepressants due to H1 block?
Sedation
What is a serious risk associated with the use of Monoamine Oxidase Inhibitors (MAOIs) and certain foods?
Cheese reaction
What type of antidepressant is Mirtazapine classified as?
Monoamine Receptor Antagonist
Which of the following is NOT a main selective serotonin reuptake inhibitor (SSRI)?
Moclobemide
Which of the following is a potential side effect of SSRIs when combined with MAO inhibitors?
Serotonin syndrome
What is a common use for SNRIs besides treating depression?
Menopause symptoms
Which of the following is NOT a tricyclic antidepressant (TCA)?
Venlafaxine
Which of the following antidepressants is known to interact with CypP450 enzymes, posing a serious risk of drug-drug interactions?
St John’s Wort
Explore the serotonergic neurotransmitter system in the brain, including its location, synthesis, release, and metabolism. Learn about the important sites of serotonin production and its role in various brain regions.
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