Wound Healing Process

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Questions and Answers

Which type of wound involves non-traumatic wounds with contaminated entry into a viscus, but with minimal spillage?

  • Contaminated
  • Clean
  • Dirty
  • Clean contaminated (correct)

What type of wound includes traumatic wounds or significant spillage from a viscus or acute inflammation?

  • Clean
  • Contaminated (correct)
  • Dirty
  • Clean contaminated

Which category of wound involves non-traumatic wounds with no septic focus and no viscus opened?

  • Clean (correct)
  • Dirty
  • Contaminated
  • Clean contaminated

What is included in the 'dirty' category of wounds?

<p>Traumatic wounds from a dirty source or significant bacterial contamination or release of pus (A)</p> Signup and view all the answers

Which of the following statements regarding inflammation is true?

<p>Recurrent attacks of acute inflammation can lead to chronic inflammatory reactions (D)</p> Signup and view all the answers

Which cellular response is associated with streptococcal tonsillitis?

<p>Increase in neutrophil count (A)</p> Signup and view all the answers

What is the nature of injury-induced vascular leakage?

<p>It leads to endothelial retractions (D)</p> Signup and view all the answers

What is the composition and location of viral endotoxin?

<p>Lipopolysaccharide present on cell surfaces (A)</p> Signup and view all the answers

What is the main component involved in increasing wound strength during wound healing?

<p>Collagen fibers (B)</p> Signup and view all the answers

Which factor does not affect wound healing?

<p>Regular exercise (D)</p> Signup and view all the answers

What causes scar contractures to be common on the flexor surfaces of joints?

<p>Wound healing by secondary intention (B)</p> Signup and view all the answers

Which type of abnormal scar extends beyond wound boundaries and does not regress spontaneously?

<p>Keloid scars (A)</p> Signup and view all the answers

What makes children's scars take longer to settle and improve?

<p>Slower tissue maturation in children (B)</p> Signup and view all the answers

What are adhesion scars composed of?

<p>Mainly fibrinogen fibers (D)</p> Signup and view all the answers

Which cells have no capacity to regenerate?

<p>Permanent cells (B)</p> Signup and view all the answers

What is the composition of granulation tissue?

<p>Capillary loops and fibroblasts (D)</p> Signup and view all the answers

During which stage does wound contraction occur?

<p>Proliferation (B)</p> Signup and view all the answers

What is the role of myofibroblasts in wound healing?

<p>Secrete collagen to form scar tissue (D)</p> Signup and view all the answers

What is the immediate goal of haemostasis in wound healing?

<p>Achieving platelet aggregation and degranulation (A)</p> Signup and view all the answers

Which cells are responsible for reducing infection in the wound?

<p>Neutrophils (A)</p> Signup and view all the answers

What stimulates angiogenesis during wound healing?

<p>Hypoxia and cytokines (D)</p> Signup and view all the answers

Which stage involves the formation of scar tissue?

<p>Maturation (A)</p> Signup and view all the answers

What is the role of collagen in wound healing?

<p>Forming scar tissue (C)</p> Signup and view all the answers

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Study Notes

  • Tissue healing in organs follows basic principles, including:
    • Cells may be labile (have good capacity to regenerate), stable (have capacity to regenerate slowly), or permanent (no capacity to regenerate).
  • Tissue architecture is important, as complex arrangements cannot be reconstructed if destroyed (e.g. renal glomeruli).
  • Complete restitution occurs when part of a labile population of cells is damaged, such as minor skin abrasions.
  • Granulation tissue is the combination of capillary loops and myofibroblasts.
  • Organization is the process where specialized tissues are repaired by formation of mature connective tissue.
  • Wound contraction is mediated by myofibroblasts, reducing the tissue defect and forming a scar.
  • Four stages of wound healing:
    • Haemostasis (immediate): Platelets aggregate and degranulate, releasing inflammatory mediators and achieving haemostasis.
    • Inflammation (0-3 days): Vasodilation, increased capillary permeability, and inflammatory cells entering the wound, causing swelling, reducing infection, and debriding damaged tissue.
    • Proliferation (3 days-3 weeks): Fibroblasts migrate, synthesize collagen, and cause wound contraction, and angiogenesis is stimulated.
    • Maturation (3 weeks-1 year): Scar tissue is formed, collagen matures, and the wound is strengthened.
  • Myofibroblasts contain actin and cause wound contraction, reducing tissue defects.
  • Collagen is secreted at the same time to form a scar.
  • Haemostasis is achieved through platelet aggregation and the complement cascade.
  • Inflammatory cells, such as neutrophils and macrophages, enter the wound and cause swelling, reduce infection, and orchestrate fibroblast migration and collagen production.
  • Fibroblasts migrate into the wound, synthesize collagen, and cause wound contraction.
  • Angiogenesis is stimulated by hypoxia and cytokines, and granulation tissue forms.
  • Scar tissue is formed, collagen matures, and the wound is strengthened during the maturation stage.

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