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Questions and Answers
Toxic granulation is associated with severe infection, chemical poisoning, and toxic states. It is characterized by large purple to black color granules and altered primary granules. It is larger than secondary granules than normal, with more than 20 granules affected. It is associated with ________
neutrophil
Dohle bodies/Amato bodies appear as single or multiple blue, round or elongated bodies containing ribosomal RNA arranged in parallel rows, located in the peripheries of the cytoplasm. They are associated with infections, burn, surgery, and chemotherapy. They are usually mistaken as ________ anomaly
May-Hegglin
Cytoplasmic vacuolation is a cytoplasmic change associated with ________
monocyte & macrophage
Pyknotic cell, smudge cell, and basket cell are nuclear abnormalities associated with ________
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Gaucher’s disease, Niemann Pick disease, Sea blue Histiocytes, Fabry’s disease, Wolman disease, and Tangier disease are non-malignant/reactive disorders affecting ________
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Study Notes
Toxic Granulation
- Associated with severe infection, chemical poisoning, and toxic states
- Characterized by large purple to black color granules and altered primary granules
- Larger than secondary granules than normal, with more than 20 granules affected
Dohle Bodies/Amato Bodies
- Appear as single or multiple blue, round or elongated bodies containing ribosomal RNA arranged in parallel rows
- Located in the peripheries of the cytoplasm
- Associated with infections, burn, surgery, and chemotherapy
- Usually mistaken as viral anomaly
Cytoplasmic Vacuolation
- A cytoplasmic change associated with cellular injury or degeneration
Nuclear Abnormalities
- Pyknotic cell, smudge cell, and basket cell are associated with cellular death or necrosis
Non-Malignant/Reactive Disorders
- Gaucher’s disease, Niemann Pick disease, Sea blue Histiocytes, Fabry’s disease, Wolman disease, and Tangier disease affect lysosomes
- These disorders are non-malignant and reactive
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Description
Test your knowledge of non-malignant anomalies and functional disorders affecting white blood cells. Identify cytoplasmic changes, anomalies, and abnormal granulocyte functions, and learn about disorders such as Job's Syndrome and Chediak-Higashi Anomaly.
