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Questions and Answers
What is the major function of neutrophils?
What stimulates the release of neutrophils from the bone marrow?
What is the half-life of neutrophils?
What is diapedesis?
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What mediates the rolling of neutrophils along endothelial cells of blood vessels?
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Study Notes
White Blood Cells (WBCs) or Leukocytes
- WBCs are relatively colorless compared to red blood cells
- Their general function is defense against infections
Classification of WBCs
- Granulocytes
- Mononuclear cells
WBC Development
- Stem cell pool: consists of hematopoietic stem cells capable of self-renewal and differentiation
- Proliferation (mitotic) pool: consists of cells that are actively dividing
- Maturation (storage) pool: consists of cells undergoing nuclear maturation that form the marrow reserve and are available for release
WBC Types and Characteristics
- Neutrophils: 50-70% in blood, pink to tan cytoplasm with violet or lilac granules
- Lymphocytes: 18-24%
- Monocytes: 2-11%
- Eosinophils: 1-3%
- Basophils: 0.5%
- Bands: last stage before the cell matures
WBC Kinetics
- Movement of neutrophil and its precursors between the different pools in the bone marrow, PB, and tissues
- 0.9-1.0 x 10^9 cells/kg per day produced
- Proliferative pool: 2.1 x 10^9 cells/kg
- Maturation pool: 5 x 10^9 cells/kg
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Description
Test your knowledge about the development and functions of white blood cells with this quiz. Learn about the different types of white blood cells and their general functions in the body.
