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Questions and Answers
What is the major function of neutrophils?
What is the major function of neutrophils?
- Initiation of blood clotting
- Transport of oxygen in the blood
- Phagocytosis and destruction of foreign material and microorganisms (correct)
- Production of antibodies
What stimulates the release of neutrophils from the bone marrow?
What stimulates the release of neutrophils from the bone marrow?
- Thrombopoietin
- Erythropoietin
- Interleukin-2
- G-CSF (correct)
What is the half-life of neutrophils?
What is the half-life of neutrophils?
- $7$ hours (correct)
- $1$ hour
- $24$ hours
- $3$ days
What is diapedesis?
What is diapedesis?
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What mediates the rolling of neutrophils along endothelial cells of blood vessels?
What mediates the rolling of neutrophils along endothelial cells of blood vessels?
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Study Notes
White Blood Cells (WBCs) or Leukocytes
- WBCs are relatively colorless compared to red blood cells
- Their general function is defense against infections
Classification of WBCs
- Granulocytes
- Mononuclear cells
WBC Development
- Stem cell pool: consists of hematopoietic stem cells capable of self-renewal and differentiation
- Proliferation (mitotic) pool: consists of cells that are actively dividing
- Maturation (storage) pool: consists of cells undergoing nuclear maturation that form the marrow reserve and are available for release
WBC Types and Characteristics
- Neutrophils: 50-70% in blood, pink to tan cytoplasm with violet or lilac granules
- Lymphocytes: 18-24%
- Monocytes: 2-11%
- Eosinophils: 1-3%
- Basophils: 0.5%
- Bands: last stage before the cell matures
WBC Kinetics
- Movement of neutrophil and its precursors between the different pools in the bone marrow, PB, and tissues
- 0.9-1.0 x 10^9 cells/kg per day produced
- Proliferative pool: 2.1 x 10^9 cells/kg
- Maturation pool: 5 x 10^9 cells/kg
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