Questions and Answers
What is the classification of Carboprost tromethamine (Hemabate)?
What action does Carboprost tromethamine (Hemabate) perform?
Stimulates contraction of the uterus
What are the indications for using Carboprost tromethamine (Hemabate)?
Used for the treatment of postpartum hemorrhage caused by uterine atony and for abortion.
The dosage for postpartum hemorrhage using Carboprost tromethamine (Hemabate) is ___ micrograms intramuscularly.
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How is Carboprost tromethamine (Hemabate) metabolized?
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How is Carboprost tromethamine (Hemabate) primarily excreted?
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What are contraindications for Carboprost tromethamine (Hemabate)?
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What are some adverse reactions of Carboprost tromethamine (Hemabate)?
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What nursing considerations should be taken when administering Carboprost tromethamine (Hemabate)?
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The dosage for Misoprostol (Cytotec) is one quarter of a ___ mcg tablet vaginally.
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What should be done if hypertonic contractions occur with Misoprostol (Cytotec)?
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When may Oxytocin induction begin after the last Misoprostol (Cytotec) dose?
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What is a precaution regarding Misoprostol (Cytotec)?
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What is the classification of Apresoline (Hydralazine)?
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What action does Apresoline (Hydralazine) perform?
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What are the dosage and route for Apresoline (Hydralazine) in pregnancy-induced hypertension?
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How is Apresoline (Hydralazine) absorbed?
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How is Apresoline (Hydralazine) excreted?
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What are contraindications for Apresoline (Hydralazine)?
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What are some adverse reactions of Apresoline (Hydralazine)?
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Study Notes
Carboprost tromethamine (Hemabate)
- Classification: Prostaglandin, oxytocic.
- Action: Stimulates uterine contractions.
- Indications: Treats postpartum hemorrhage from uterine atony and is used in abortion.
- Dosage & Route: For postpartum hemorrhage, administer 250 micrograms intramuscularly, with possible repeats every 15 to 90 minutes; maximum total dose is 2 mg.
- Absorption: Metabolized by the liver and lung enzymes.
- Excretion: Primarily excreted in urine.
- Contraindications: Avoid in women with hypersensitivity to carboprost, acute pelvic inflammatory disease, and specific cardiac, pulmonary, renal, or hepatic diseases. Use caution in those with asthma, hypotension/hypertension, anemia, jaundice, diabetes, epilepsy, or previous uterine surgery.
- Adverse Reactions: Excessive doses can cause tetanic contractions, uterine rupture, hypertonus when used with oxytocin, nausea, vomiting, diarrhea, fever, chills, headaches, and changes in blood pressure.
- Nursing Considerations: Store refrigerated, administer via deep intramuscular injection, rotate injection sites, monitor vital signs, and administer antiemetics as necessary.
Misoprostol (Cytotec)
- Dosage: Administer 25 mcg vaginally from a quarter of a 100-mcg tablet, repeating every 3-6 hours for labor induction; a 50-mcg dose may cause hypertonic contractions.
- Actions for Hypertonic Contractions: Place the patient in a side-lying position; provide oxygen and administer tocolytic drugs like terbutaline or magnesium sulfate if necessary.
- Oxytocin Induction: Can begin at least 4 hours after the last dose of Misoprostol.
- Precautions: Misoprostol is only FDA-approved for peptic ulcer treatment but is commonly used for labor induction and cervical ripening. The manufacturer will not seek additional approval. Contraindicated in women with previous cesarean or uterine surgery. Hospital pharmacy should prepare accurate 25-mcg doses.
Apresoline (Hydralazine)
- Classification: Antihypertensive.
- Action: Relaxes arterial smooth muscle leading to reduced blood pressure.
- Dosage & Route: For pregnancy-induced hypertension, administer 5 to 10 mg intravenously every 15 to 20 minutes as needed; duration of action lasts 3 to 8 hours.
- Absorption: Widely distributed; crosses the placenta and enters breast milk in minimal amounts.
- Excretion: Metabolized and excreted by the liver.
- Contraindications: Avoid in coronary artery disease, cerebrovascular disease, and hypersensitivity to hydralazine. Use cautiously in pregnancy (category C).
- Adverse Reactions: May cause headache, dizziness, drowsiness, hypotension (affecting uterine blood flow), and epigastric pain.
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Description
This quiz focuses on essential obstetric medications covered in Week 5, including Carboprost tromethamine (Hemabate). It highlights classifications, actions, and indications for use, particularly related to postpartum care. Prepare to test your knowledge on crucial medications used in obstetrics.