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Questions and Answers
What is the generic name for Carboprost tromethamine?
What is the generic name for Carboprost tromethamine?
- Hemabate
- Prostaglandin
- Oxytocin
- Carboprost tromethamine (correct)
Match Carboprost tromethamine with its trade name:
Match Carboprost tromethamine with its trade name:
Carboprost tromethamine = Hemabate
What therapeutic class does Carboprost tromethamine belong to?
What therapeutic class does Carboprost tromethamine belong to?
- Analgesics
- Antibiotics
- Antidepressants
- Oxytocics (correct)
What is the indication for use of Carboprost tromethamine?
What is the indication for use of Carboprost tromethamine?
The initial dosage of Carboprost tromethamine is _____ mcg deep IM.
The initial dosage of Carboprost tromethamine is _____ mcg deep IM.
What is a black box warning associated with Carboprost tromethamine?
What is a black box warning associated with Carboprost tromethamine?
What is a common adverse reaction to Carboprost tromethamine?
What is a common adverse reaction to Carboprost tromethamine?
Carboprost tromethamine should be administered intravenously.
Carboprost tromethamine should be administered intravenously.
What should be closely monitored when administering Carboprost tromethamine?
What should be closely monitored when administering Carboprost tromethamine?
Carboprost tromethamine can be used in patients with acute pelvic inflammatory disease.
Carboprost tromethamine can be used in patients with acute pelvic inflammatory disease.
In what settings is Carboprost tromethamine intended to be used?
In what settings is Carboprost tromethamine intended to be used?
What does Carboprost tromethamine produce in uterine smooth muscle?
What does Carboprost tromethamine produce in uterine smooth muscle?
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Study Notes
Carboprost Tromethamine Overview
- Generic Name: Carboprost tromethamine
- Trade Name(s): Hemabate
Medication Classes
- Therapeutic Class: Oxytocics, which help induce contractions
- Pharmacologic Class: Prostaglandins, a group of lipid compounds with various roles in the body
Indications for Use
- Termination of Pregnancy: Effective for pregnancies between 13 and 20 weeks of gestation
- Postpartum Hemorrhage: Used for uterine atony not responsive to typical management methods
Dosage Information
- Pregnancy Termination:
- Initial dose: 250 mcg IM
- Optionally, a test dose of 100 mcg IM can be administered
- Subsequent doses every 1.5 to 3.5 hours based on uterine response, max total of 12 mg, not exceeding 2 days
- Postpartum Hemorrhage:
- Administer 250 mcg IM with repeat doses every 15 to 90 minutes as needed, maximum total of 2 mg over eight doses
Administration Guidelines
- Route: Administered via deep intramuscular (IM) injection
- Black Box Warning: Only given by trained hospital personnel with access to emergency care and surgical facilities
- Injection Notes: Use a tuberculin syringe and rotate injection sites; do not administer IV, and store in refrigerator
Mechanism of Action
- Induces strong, prompt contractions of uterine smooth muscle
- Onset & Duration: Onset is unknown, peaks within 15-60 minutes, lasts approximately 24 hours
Adverse Reactions
- CNS: Fever, headache, anxiety, paresthesia, syncope
- Cardiovascular: Arrhythmias, chest pain, flushing
- Gastrointestinal: Nausea, vomiting, diarrhea
- Genitourinary: Risks include uterine rupture and excessive uterine bleeding
- Other: Rash, breast tenderness, chills, hot flashes
Drug Interactions
- Drug-drug Interaction: Concurrent use with other oxytocics may enhance effects; should be avoided
- Lab Test Results: No significant interactions reported
Contraindications and Cautions
- Contraindications: Hypersensitivity, active cardiac, pulmonary, renal, or hepatic diseases, and acute pelvic inflammatory disease
- Caution: History of asthma, hypertension, diabetes, and prior uterine surgery should be carefully considered
Pregnancy, Lactation, and Reproduction
- Not indicated for patients seeking to continue pregnancy or in a viable fetus
- Unknown whether the drug passes into breast milk
Nursing Considerations
- Dosage Compliance: Strict adherence to dosing guidelines is essential
- Administration Form: IM injection is preferred to avoid complications associated with vaginal suppositories
- Preventative Measures: Pretreating with antiemetics and antidiarrheals minimizes common gastrointestinal side effects
Patient Education
- Instruction: Educate patients and families about the drug’s purpose, administration, and potential side effects
- Reporting: Encourage prompt reporting of any adverse reactions or symptoms of hypersensitivity
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