Podcast
Questions and Answers
What are NMBAs termed as?
What are NMBAs termed as?
- Paralytics or muscle relaxants (correct)
- Bronchodilators
- Anti-inflammatory
- Parasympathetic agent
What does NMBA cause?
What does NMBA cause?
- Vasodilation
- Increases fatigue
- Skeletal muscle weakness or paralysis (correct)
- Tachycardia / increase BP
Mode of action of NMBA? Select all that apply
Mode of action of NMBA? Select all that apply
- Inhibits cell wall synthesis and is bactericidal
- Produces effect at neuromuscular junction by interfering with action of Acetylcholine. (correct)
- Binds with Alpha and beta receptors to activate adrenegic effect that causes bronchodilator, vasodilation.
- Depolarizes the presynaptic and postsynaptic membrane or compete with Ach for binding at the receptors or make the receptors more sensitive for Ach. (correct)
Clinical uses of NMBA?
Clinical uses of NMBA?
What are the 2 groups of NMBA? Select all that apply
What are the 2 groups of NMBA? Select all that apply
What does Depolarizing agent(s) do?
What does Depolarizing agent(s) do?
Agent(s) that belong to depolarizing NMBA?
1 Albuterol, Levalbuterol
2 Mucomyst
3 Atrovent, tiotropium bromide
4 Succinylcholine
5 Omalizumab
6 Accolate, Montelukast
Agent(s) that belong to depolarizing NMBA?
1 Albuterol, Levalbuterol 2 Mucomyst 3 Atrovent, tiotropium bromide 4 Succinylcholine 5 Omalizumab 6 Accolate, Montelukast
What does Non depolarizing NMBA do?
What does Non depolarizing NMBA do?
What is the clinical use of NMBA in the operating room?
What is the clinical use of NMBA in the operating room?
What is the clinical use of NMBA in the ICU unit?
What is the clinical use of NMBA in the ICU unit?
What are the Clinical uses of NMBAs?
1 To facilitate endotracheal intubation
2 To obtain muscle relaxation
3 To reduce asthma attack
4 To reduce ICP in intubated patients
5 To reduce mucus production
6 To terminate convulsive status epilepticus and tetanus refractory to other therapies
What are the Clinical uses of NMBAs?
1 To facilitate endotracheal intubation 2 To obtain muscle relaxation 3 To reduce asthma attack 4 To reduce ICP in intubated patients 5 To reduce mucus production 6 To terminate convulsive status epilepticus and tetanus refractory to other therapies
What are the common examples of ventilated patients who require muscle relaxation? (Select all the apply)
What are the common examples of ventilated patients who require muscle relaxation? (Select all the apply)
What does the CNS consist of?
1 Peripheral nerves
2 Somatic motor Neurons
3 Brain
4 Autonomic motor neurons
5 Spinal cord
6 Sensory afferent neurons
What does the CNS consist of? 1 Peripheral nerves 2 Somatic motor Neurons 3 Brain 4 Autonomic motor neurons 5 Spinal cord 6 Sensory afferent neurons
What does the PNS consist of?
1 Brain
2 Sensory afferent neurons
3 Autonomic motor neurons
4 Spinal cord
5 Somatic motor neurons
6 the heart
What does the PNS consist of?
1 Brain 2 Sensory afferent neurons 3 Autonomic motor neurons 4 Spinal cord 5 Somatic motor neurons 6 the heart
What is the correct process of AcH binding to receptors and what can it cause?
What is the correct process of AcH binding to receptors and what can it cause?
What is an enzyme that breaks down AcH?
What is an enzyme that breaks down AcH?
What does the neuron consist of? select all the apply
What does the neuron consist of? select all the apply
What are the two ways muscle contraction can be blocked? Define them.
What are the two ways muscle contraction can be blocked? Define them.
What is the mechanism of action of Non-depolarizing agents?
1 Blocks the channel of postsynaptic cholinergic receptors by occupying channel pore
2 Affects the receptors from the internal side and reducing the channel opening
3 Open sodium channels and depolarize postsynaptic muscle membrane
5 Has a resistant to AchE, allowing persistent and longer duration of action
6 Competes with endogenous AcH for receptor occupancy.
What is the mechanism of action of Non-depolarizing agents?
1 Blocks the channel of postsynaptic cholinergic receptors by occupying channel pore 2 Affects the receptors from the internal side and reducing the channel opening 3 Open sodium channels and depolarize postsynaptic muscle membrane 5 Has a resistant to AchE, allowing persistent and longer duration of action 6 Competes with endogenous AcH for receptor occupancy.
Is the effect of Non-depolarizing agents dose related? Meaning that with large doses, it overcomes the effects of AcH more and blocks more receptors?
Is the effect of Non-depolarizing agents dose related? Meaning that with large doses, it overcomes the effects of AcH more and blocks more receptors?
Can Non-depolarizing agents be reversed? Why or why not?
Can Non-depolarizing agents be reversed? Why or why not?
What is the pharmacokinetic of Non-depolarizing agents?
What is the pharmacokinetic of Non-depolarizing agents?
Match the Non-depolarizing agents (which is which)
Match the Non-depolarizing agents (which is which)
Non-depolarizing agents has a short duration of action compared with depolarizing agent, succinylcholine.
Non-depolarizing agents has a short duration of action compared with depolarizing agent, succinylcholine.
What are the factors that are dose related for Rocuronium? Select all that apply
What are the factors that are dose related for Rocuronium? Select all that apply
When normal conduction returns __ of AcH receptors may still be occupied by a blocker.
When normal conduction returns __ of AcH receptors may still be occupied by a blocker.
Metabolism, which is which?
Metabolism, which is which?
What is the difference between Atracurium and Cisatracurium?
What is the difference between Atracurium and Cisatracurium?
What is the breakdown product of Hoffmann degradation called?
What is the breakdown product of Hoffmann degradation called?
What are the adverse effects of Non-depolarizing agents in the following categories, match.
What are the adverse effects of Non-depolarizing agents in the following categories, match.
What are the agents that can reverse the action of Non-depolarizing agents?
What are the agents that can reverse the action of Non-depolarizing agents?
Match the following Cholinesterase inhibitors/non-depolaring revere agents to its definition
Match the following Cholinesterase inhibitors/non-depolaring revere agents to its definition
Depolarizing agent(s) short acting and no agents can reverse the blockade
Depolarizing agent(s) short acting and no agents can reverse the blockade
What is the dosage, delivery method and duration for succinylcholine?
What is the dosage, delivery method and duration for succinylcholine?
What patients are ideal for use of succinylcholine?
What patients are ideal for use of succinylcholine?
How many seconds does succinylcholine cause total paralysis to the body?
How many seconds does succinylcholine cause total paralysis to the body?
What are the mechanism of action of succinylcholine?
1 Opens sodium channel and depolarizes’ postsynaptic muscle membrane
2 Competes with AcH to occupy AcH receptors that causes its blockage
3 Resistant to effects of AchE
4 Reduced the opening of receptors
5 Last longer at the receptor sites resulting flaccid muscles
6 Depolarization occurs and is maintained until succinylcholine leaves the body
What are the mechanism of action of succinylcholine?
1 Opens sodium channel and depolarizes’ postsynaptic muscle membrane 2 Competes with AcH to occupy AcH receptors that causes its blockage 3 Resistant to effects of AchE 4 Reduced the opening of receptors 5 Last longer at the receptor sites resulting flaccid muscles 6 Depolarization occurs and is maintained until succinylcholine leaves the body
What are the 2 phases of Succinylcholine effect in the body? Select all that applies.
What are the 2 phases of Succinylcholine effect in the body? Select all that applies.
What are the adverse effects of Succinylcholine? Select all that applies
What are the adverse effects of Succinylcholine? Select all that applies
What kind of patients will have sensitivity to Succinylcholine — which will not metabolize it effectively?
What kind of patients will have sensitivity to Succinylcholine — which will not metabolize it effectively?
NMBA is beneficial in?
NMBA is beneficial in?
List the risks and precautions when using NMBAs
List the risks and precautions when using NMBAs
NMBA causes muscle paralysis and loss of consciousness .
NMBA causes muscle paralysis and loss of consciousness .
What should we monitor when patient is put under sedation and analgesia?
What should we monitor when patient is put under sedation and analgesia?
Choose the medications that belong to: Analgesics
Choose the medications that belong to: Analgesics
Choose the medications that belong to: Amenestic
Choose the medications that belong to: Amenestic
What agent works well (can be additive, antagonistic, synergistic) with NMBAs?
What agent works well (can be additive, antagonistic, synergistic) with NMBAs?
What agents antagonizes’ NMBA?
What agents antagonizes’ NMBA?
What clinical factors can potentiate neuromuscular blockade?
What clinical factors can potentiate neuromuscular blockade?
Flashcards
Capital of France (example flashcard)
Capital of France (example flashcard)
Paris
