Vitamins as Medicines
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Questions and Answers

What are vitamin supplements effective for, according to scientific evidence?

Vitamin supplements are effective for treating people with specific vitamin deficiency diseases, metabolic defects that increase vitamin requirements, and a few other medical conditions.

What role does vitamin D play in the immune system?

Vitamin D helps control the body's inflammatory response to viruses and may interfere with the virus's ability to make copies of itself.

What is the current evidence regarding the use of vitamin D supplements to prevent or fight COVID-19?

There is no strong scientific evidence that supports the use of vitamin D supplementation to reduce the severity and deadliness of COVID-19.

What is the potential link between vitamin D levels and the severity of COVID-19?

<p>People with lower than normal vitamin D levels may have a greater likelihood of developing a severe or fatal case of COVID-19 if they become infected.</p> Signup and view all the answers

What is the current understanding of the effectiveness of vitamin D supplements in preventing acute respiratory tract infections?

<p>Taking vitamin D supplements is a safe and effective way to prevent acute respiratory tract infections that can cause pneumonia.</p> Signup and view all the answers

What is the purpose of ongoing research into vitamin D supplementation and COVID-19?

<p>Scientists are studying whether vitamin D supplementation can help prevent the spread of COVID-19 within populations.</p> Signup and view all the answers

What is the role of vitamin D in regulating the immune response to viruses that cause respiratory infections?

<p>Vitamin D helps control the body's inflammatory response to viruses that cause respiratory infections.</p> Signup and view all the answers

What is the current state of evidence regarding the use of vitamin D supplements to prevent or treat COVID-19?

<p>There is currently no strong scientific evidence that supports the use of vitamin D supplementation to reduce the severity and deadliness of COVID-19.</p> Signup and view all the answers

What is the primary concern associated with high intakes of vitamin E supplements?

<p>Increased risk of prostate cancer (in men) and hemorrhagic stroke</p> Signup and view all the answers

Why did the 17-year-old male take megadoses of niacin, and what was the consequence?

<p>To interfere with urine testing for marijuana use, resulting in abnormal liver function requiring hospitalization</p> Signup and view all the answers

Why may scientists need to test higher doses of vitamin E to detect positive effects on health?

<p>Because the typical doses used in clinical studies may be insufficient to produce noticeable benefits</p> Signup and view all the answers

What is the medical purpose of prescribing megadoses of niacin, and what precaution should be taken?

<p>To reduce elevated LDL cholesterol levels, and consulting a qualified medical practitioner to avoid toxicity</p> Signup and view all the answers

What is the controversy surrounding vitamin B-6 supplementation for relieving premenstrual syndrome (PMS)?

<p>Studies provide mixed results, and high doses can be toxic, causing sensory nerve damage</p> Signup and view all the answers

What is the relationship between folic acid, B-6, and B-12 deficiencies and cardiovascular disease?

<p>Deficiencies may be associated with elevated homocysteine levels, but supplementing with these vitamins does not reduce the risk of heart disease or stroke</p> Signup and view all the answers

What is the potential role of vitamin B-6 in cognitive decline associated with aging?

<p>Some scientists believe poor vitamin B-6 status may contribute to cognitive decline</p> Signup and view all the answers

Why are major studies inconclusive about the benefits of vitamin E supplementation?

<p>The alpha-tocopherol form of vitamin E may not have beneficial effects, and study designs may not be suitable to detect positive outcomes</p> Signup and view all the answers

What is the significance of homocysteine levels in the context of cardiovascular disease?

<p>Elevated homocysteine levels may be a biochemical marker or risk factor for cardiovascular disease</p> Signup and view all the answers

What is the general theme of the 'Did YOU Know?' section regarding vitamins and health?

<p>The importance of responsible supplementation and consulting credible sources of nutrition information</p> Signup and view all the answers

What is the foundation of the belief that vitamins are useful for preventing or treating serious chronic diseases?

<p>The fact that a very small amount of a vitamin can prevent or cure the vitamin's deficiency disease.</p> Signup and view all the answers

What is the association between eating diets rich in fruits and vegetables and certain health outcomes?

<p>Lower risk of certain cancers, heart disease, and age-related macular degeneration.</p> Signup and view all the answers

What was the outcome of taking vitamin A or beta-carotene supplements to reduce the risk of cancer in clinical studies?

<p>No support was found to reduce the risk of cancer.</p> Signup and view all the answers

What are the major risk factors for age-related macular degeneration (AMD)?

<p>Genetics, smoking, and advanced age.</p> Signup and view all the answers

What is the region within the eye that provides the most detailed central vision?

<p>The macula.</p> Signup and view all the answers

What combination of substances slowed the progression of vision loss associated with advanced macular degeneration in the Age-Related Eye Disease Study (AREDS)?

<p>Vitamins C and E, beta-carotene, and the minerals copper and zinc.</p> Signup and view all the answers

What supplements were found to delay the progression of AMD in a follow-up study?

<p>Lutein and zeaxanthin supplements.</p> Signup and view all the answers

What is the current understanding of the effectiveness of taking large doses of vitamins and related compounds as medications?

<p>People should be cautious when using megadoses of vitamins as they can have druglike effects and cause side effects.</p> Signup and view all the answers

Why are people misled into believing that vitamins are helpful and safe in any amount?

<p>Because a very small amount of a vitamin can prevent or cure the vitamin's deficiency disease.</p> Signup and view all the answers

What is the current evidence regarding the usefulness of taking antioxidant supplements to prevent age-related macular degeneration?

<p>There is no scientific evidence that taking antioxidant supplements prevents healthy people from developing AMD.</p> Signup and view all the answers

What is the primary function of cognitive functions?

<p>to remember, understand, and use information</p> Signup and view all the answers

According to reliable studies, what is the effect of short-term use of vitamin B-6 on cognitive decline among older adults?

<p>No evidence suggests that it can prevent or slow cognitive decline</p> Signup and view all the answers

What was the title of the bestselling book published by Dr. Linus Pauling in 1970?

<p>Vitamin C and the Common Cold</p> Signup and view all the answers

What is the effect of routine vitamin C supplementation on the common cold in the general population?

<p>It does not prevent colds</p> Signup and view all the answers

What is the potential benefit of taking large doses of vitamin C on cold symptoms?

<p>It may reduce the duration of cold symptoms by a day or so</p> Signup and view all the answers

What is the claim of promoters of vitamin drips?

<p>They can improve skin and hair condition, relieve hangovers, and more</p> Signup and view all the answers

What is the risk associated with receiving IV vitamin infusions?

<p>Skin infection or serious blood infection if sterile techniques are not used</p> Signup and view all the answers

How can a person provide their body with all the necessary vitamins?

<p>By eating a balanced diet rich in fruits and vegetables</p> Signup and view all the answers

How does vitamin C reduce the risk of CVD as an antioxidant?

<p>It reduces the oxidation of LDL cholesterol</p> Signup and view all the answers

What is the result of oxidized LDL cholesterol?

<p>It is more likely to contribute to atherosclerosis</p> Signup and view all the answers

What is a major limitation of studies examining the effect of vitamin C supplementation on CVD risk?

<p>The studies have not spanned long enough to capture the full effects of vitamin C supplementation on CVD risk, as CVD takes years and decades to develop.</p> Signup and view all the answers

What is the relationship between vitamin C-rich diets and cancer risk?

<p>Diets rich in vitamin C from fruits and vegetables are associated with a lower risk of cancer, but taking vitamin C supplements does not seem to have the same effect.</p> Signup and view all the answers

Why is it unlikely that vitamin C supplements can prevent or treat complex chronic diseases like CVD and cancer?

<p>These diseases have multiple causes, including inherited factors and lifestyle practices, and are not likely to be prevented or treated by a single supplement like vitamin C.</p> Signup and view all the answers

What is the recommendation of nutrition experts for achieving and maintaining good health?

<p>Combining a nutritious diet with regular exercise.</p> Signup and view all the answers

What is the potential benefit of consuming a variety of vitamins, antioxidants, and phytochemicals in their natural states and concentrations?

<p>It may be the most effective way to lower the risk of CVD, cancer, and other chronic diseases.</p> Signup and view all the answers

Why do nutrition experts recommend eating a variety of fruits and vegetables rather than taking antioxidant or phytochemical supplements?

<p>Isolating or synthesizing these substances may reduce their usefulness and increase their risks.</p> Signup and view all the answers

What is the estimated amount spent by Americans on dietary supplements in 2019?

<p>Over $39 billion.</p> Signup and view all the answers

According to the U.S. Preventive Services Task Force, what is the current state of evidence for using dietary supplements to prevent major chronic diseases?

<p>There is a lack of credible scientific evidence for or against using dietary supplements for this purpose.</p> Signup and view all the answers

What is the exception to the general lack of evidence for the effectiveness of dietary supplements in preventing chronic diseases?

<p>There is strong evidence to advise against the use of beta-carotene supplements, especially among smokers.</p> Signup and view all the answers

What is the greatest beneficial impact on long-term health that an individual can make?

<p>Quitting tobacco use may have a greater beneficial impact on long-term health than improving diet or increasing physical activity level.</p> Signup and view all the answers

Study Notes

Vitamins as Medicines

  • Vitamin supplements are effective for treating people with specific vitamin deficiency diseases, metabolic defects that increase vitamin requirements, and a few other medical conditions.
  • However, scientific evidence does not support claims that megadoses of vitamins can prevent or treat everything from gray hair to lung cancer.

Vitamin D and COVID-19

  • Vitamin D plays important roles in maintaining proper functioning of the immune system, including regulating the immune system.
  • Vitamin D may help control the body's inflammatory response to viruses that cause respiratory infections.
  • Taking vitamin D supplements is a safe and effective way to prevent acute respiratory tract infections that can cause pneumonia.
  • There is currently no strong scientific evidence that supports the use of vitamin D supplementation to reduce the severity and deadliness of COVID-19.

Cancer

  • Results of clinical studies have not provided support for taking vitamin A or beta-carotene supplements to reduce the risk of cancer.
  • Smoking and taking beta-carotene supplements may increase the risk of lung cancer.
  • Eating diets rich in fruits and vegetables lowers the risk of AMD.
  • The combination of vitamins C and E, beta-carotene, and the minerals copper and zinc slows the progression of vision loss associated with advanced macular degeneration.
  • Lutein and zeaxanthin supplements delay the progression of AMD.

Vitamin E as Medicine?

  • High intakes of vitamin E do not consistently reduce the risk of CVD, cancer, and mild cognitive impairment.
  • Vitamin E supplements have been associated with an increased risk of prostate cancer and hemorrhagic stroke.

Niacin as Medicine?

  • Megadoses of niacin can lower elevated LDL cholesterol levels, but may be toxic and require consultation with a qualified medical practitioner.

Vitamin B-6 as Medicine?

  • Large doses of vitamin B-6 may not relieve premenstrual syndrome (PMS) symptoms.
  • Vitamin B-6 is toxic in high doses, causing sensory nerve damage.

Folic Acid, B-6, and B-12 as Medicine?

  • Elevated blood levels of homocysteine may be a biochemical marker or risk factor for CVD, but taking these B vitamins does not reduce the risk of heart disease or stroke.

Vitamin C as Medicine?

  • Routine vitamin C supplementation does not prevent the common cold in the general population.
  • Taking large doses of vitamin C may reduce the duration of cold symptoms by a day or so.
  • Vitamin C may reduce the oxidation of LDL cholesterol, but studies have not provided consistent evidence that it reduces the risk of CVD or dying from the condition.

Final Thoughts

  • There is a lack of credible scientific evidence for or against using dietary supplements, including vitamins, to prevent major chronic diseases.
  • Consuming a wide variety of vitamins, antioxidants, and phytochemicals in their natural states and concentrations (in foods) may be the most effective way to lower the risk of CVD, cancer, and many other serious chronic diseases.

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Evaluate the use of vitamin supplements for their potential health benefits and hazards, including treating vitamin deficiency diseases and medical conditions.

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