Biochem L1C | Lipid Soluble Vitamins
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Questions and Answers

What is the general cause of deficiency for lipid-soluble vitamins?

  • Inadequate intake/malnutrition (correct)
  • Complication of GI surgery
  • Poor absorption from the intestinal tract
  • Increased demand such as pregnancy

Which of the following vitamins act as hormones?

  • Vitamin D and E
  • Vitamin A and D (correct)
  • Vitamin E and K
  • Vitamin A and K

Which lipid-soluble vitamin is not readily absorbed from the diet?

  • Vitamin A
  • Vitamin K
  • Vitamin E
  • Vitamin D (correct)

What are the shared characteristics of lipid-soluble vitamins?

<p>Stored in tissues and circulating concentrations kept constant (A)</p> Signup and view all the answers

Which vitamin can be toxic in excess, according to recent evidence?

<p>Vitamin A (A)</p> Signup and view all the answers

When may deficiency of lipid-soluble vitamins develop?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a risk factor for developing hemorrhagic disease of the newborn due to vitamin K deficiency?

<p>Premature birth (C)</p> Signup and view all the answers

Which vitamin is required for the post-translational modification of coagulation factors II, VII, IX, and X?

<p>Vitamin K (B)</p> Signup and view all the answers

What can cause deficiency of vitamin K in humans?

<p>Liver disease (C)</p> Signup and view all the answers

Which condition may result from vitamin E deficiency in premature infants?

<p>Hemolytic anemia (B)</p> Signup and view all the answers

Which factor contains carboxylated residues requiring vitamin K for their activation?

<p>Factor II (Prothrombin) (A)</p> Signup and view all the answers

What is the primary function of vitamin E?

<p>Protects cell membranes (B)</p> Signup and view all the answers

What condition is associated with deficiency of vitamin K in newborn infants?

<p>Hemorrhagic disease of the newborn (A)</p> Signup and view all the answers

What group of drugs inhibits the action of vitamin K?

<p>(WARFARIN) Dicoumarin group (C)</p> Signup and view all the answers

What is the main source of vitamin K for newborn infants?

<p>Intestinal microflora (D)</p> Signup and view all the answers

What condition may develop in premature infants due to vitamin E deficiency?

<p>Hemolytic anemia (C)</p> Signup and view all the answers

Which vitamin is required for the carboxylation of specific glutamic acid residues in coagulation factors?

<p>Vitamin K (B)</p> Signup and view all the answers

What may cause hemorrhagic disease of the newborn due to vitamin K deficiency?

<p>Inefficient placental transfer of vitamin K (B)</p> Signup and view all the answers

Which of the following is true about the transport of calcitriol in plasma?

<p>It is transported in plasma bound to vitamin D binding protein (DBP) (B)</p> Signup and view all the answers

What is the primary stimulus for the synthesis of 1,25(OH)2D3 from 25(OH)D3?

<p>Parathyroid hormone (PTH) (C)</p> Signup and view all the answers

What is the function of calcitriol in the intestinal epithelium?

<p>It induces gene expression in the nucleus (A)</p> Signup and view all the answers

What is a common outcome of vitamin D deficiency during pregnancy and infancy?

<p>Development of rickets in children and osteomalacia in adults (B)</p> Signup and view all the answers

What are the adverse health outcomes linked to low vitamin D levels during pregnancy and infancy?

<p>Increased incidence of autoimmune diseases (B)</p> Signup and view all the answers

What is the most likely cause of the 28-year-old woman's symptoms based on the given information?

<p>Malabsorption syndrome (B)</p> Signup and view all the answers

What is the primary source of α-tocopherol?

<p>Green leafy vegetables (D)</p> Signup and view all the answers

Which lipid-containing structures are associated with α-tocopherol due to its lipid solubility?

<p>Membranes, lipoproteins, and fat deposits (C)</p> Signup and view all the answers

What is the main function of α-Tocopherol?

<p>Inhibit the activity of protein kinase C (B)</p> Signup and view all the answers

Which statement about vitamin D toxicity is correct based on the given information?

<p>Deposition of Ca2+ in soft tissue is a common outcome (A)</p> Signup and view all the answers

Which of the following is the most likely cause of night blindness and dry, scaly skin in a 32-year-old woman with decreased serum levels of retinol?

<p>Impaired absorption of fat-soluble vitamins (B)</p> Signup and view all the answers

What is the storage form of vitamin D found in the liver and in the circulation?

<p>Calcidiol (B)</p> Signup and view all the answers

Which form of vitamin D is synthesized in the skin by UV irradiation of 7-dehydrocholesterol?

<p>Cholecalciferol (C)</p> Signup and view all the answers

What can cause vitamin D deficiency by disturbing enterohepatic circulation?

<p>Impaired hepatic hydroxylation of vitamin D (C)</p> Signup and view all the answers

Which vitamin is a plant pigment that serves as a pro-vitamin for vitamin A?

<p>Beta-carotene (C)</p> Signup and view all the answers

In which organ is retinol esterified and stored in the form of retinyl esters, bound to the cytosolic retinol-binding proteins?

<p>Liver (C)</p> Signup and view all the answers

Which hydroxylase forms calcitriol (1α,25dihydroxycholecalciferol; 1,25[OH]2D3) from calcidiol (25hydroxycholecalciferol; 25[OH]D3) in the renal tubules?

<p>CYP27B1 (C)</p> Signup and view all the answers

What is the most common symptom of retinoid deficiency in children and pregnant women?

<p>Night blindness (D)</p> Signup and view all the answers

Which receptor interacts with all-trans and 9-cis-retinoic acid?

<p>RAR (retinoid acid receptors) (A)</p> Signup and view all the answers

What does retinoic acid interact with to regulate growth, differentiation, and proliferation of cells during embryonic development and organogenesis?

<p>RAR (retinoid acid receptors) (B)</p> Signup and view all the answers

What health condition may result from excessive intake of retinoid?

<p>Increased intracranial pressure (D)</p> Signup and view all the answers

What is the precursor and storage form of retinol found in animals?

<p>Retinyl palmitate (B)</p> Signup and view all the answers

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