Podcast
Questions and Answers
What is the name of the virus that causes COVID-19?
What is the name of the virus that causes COVID-19?
How is SARS-CoV-2 transmitted?
How is SARS-CoV-2 transmitted?
What is the role of ACE2 in the COVID-19 infection process?
What is the role of ACE2 in the COVID-19 infection process?
What is the function of the RBD region of the viral spike protein?
What is the function of the RBD region of the viral spike protein?
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Which of the following is NOT a component of SARS-CoV-2?
Which of the following is NOT a component of SARS-CoV-2?
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Which of the following methods can be used to diagnose COVID-19?
Which of the following methods can be used to diagnose COVID-19?
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Where does SARS-CoV-2 replication occur in the body?
Where does SARS-CoV-2 replication occur in the body?
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What is the role of endosome in SARS-CoV-2 infection?
What is the role of endosome in SARS-CoV-2 infection?
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What is the primary mode of transmission for Norovirus?
What is the primary mode of transmission for Norovirus?
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Which of the following statements is true regarding Norovirus?
Which of the following statements is true regarding Norovirus?
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What are common clinical effects associated with viral infections in the gastrointestinal tract?
What are common clinical effects associated with viral infections in the gastrointestinal tract?
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Which virus is the most common cause of viral gastroenteritis in children?
Which virus is the most common cause of viral gastroenteritis in children?
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What distinguishes Norovirus from bacterial infections in terms of severity?
What distinguishes Norovirus from bacterial infections in terms of severity?
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What is the primary cause of the maculopapular rash seen in measles infections?
What is the primary cause of the maculopapular rash seen in measles infections?
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Which of the following features is NOT associated with mumps virus?
Which of the following features is NOT associated with mumps virus?
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What serious complication can mumps cause in postpubertal males?
What serious complication can mumps cause in postpubertal males?
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Which of the following statements about rubella is accurate?
Which of the following statements about rubella is accurate?
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What is the common method of transmission for measles, mumps, and rubella?
What is the common method of transmission for measles, mumps, and rubella?
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What type of vaccine is used for measles, mumps, and rubella prevention?
What type of vaccine is used for measles, mumps, and rubella prevention?
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What is a differentiating feature of rubella compared to measles and mumps?
What is a differentiating feature of rubella compared to measles and mumps?
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What defines the viral genome structure of measles and mumps viruses?
What defines the viral genome structure of measles and mumps viruses?
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What is the diagnosis method for Norovirus infection?
What is the diagnosis method for Norovirus infection?
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Which of the following symptoms is NOT associated with Rotavirus infection?
Which of the following symptoms is NOT associated with Rotavirus infection?
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What is the main virulence factor of Norovirus?
What is the main virulence factor of Norovirus?
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What is a common complication resulting from Rotavirus infection?
What is a common complication resulting from Rotavirus infection?
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Which of the following vaccines is used for Rotavirus prevention?
Which of the following vaccines is used for Rotavirus prevention?
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Which enteric virus binds to the beta-adrenergic receptor during its pathogenesis?
Which enteric virus binds to the beta-adrenergic receptor during its pathogenesis?
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What is the supportive treatment for Norovirus infections?
What is the supportive treatment for Norovirus infections?
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Which of these statements about the incubation period of Rotavirus is true?
Which of these statements about the incubation period of Rotavirus is true?
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What immediate immune response is triggered by an infection migrating to the alveoli?
What immediate immune response is triggered by an infection migrating to the alveoli?
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Which consequence is associated with bilateral alveolar damage during a severe infection?
Which consequence is associated with bilateral alveolar damage during a severe infection?
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What is the primary mechanism of action for Remdesivir in treating COVID-19?
What is the primary mechanism of action for Remdesivir in treating COVID-19?
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What is a key feature of the Pfizer-BioNTech vaccine?
What is a key feature of the Pfizer-BioNTech vaccine?
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Which childhood virus is known for causing lifelong immunity after infection?
Which childhood virus is known for causing lifelong immunity after infection?
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What type of virus is the Mumps virus classified as?
What type of virus is the Mumps virus classified as?
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What type of viral structure does the Rubella virus possess?
What type of viral structure does the Rubella virus possess?
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What kind of treatment is available for parvovirus B19?
What kind of treatment is available for parvovirus B19?
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Which of the following options describes one of the considerations for Nirmatrelvir/Ritonavir treatment?
Which of the following options describes one of the considerations for Nirmatrelvir/Ritonavir treatment?
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What stage of immunity is expected after vaccination for Measles and Rubella?
What stage of immunity is expected after vaccination for Measles and Rubella?
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What disease is caused by Parvovirus B19?
What disease is caused by Parvovirus B19?
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How is Parvovirus B19 primarily transmitted?
How is Parvovirus B19 primarily transmitted?
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Which of the following is a characteristic of Human Herpesvirus 6?
Which of the following is a characteristic of Human Herpesvirus 6?
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Which enteric virus is known for causing paralytic disease?
Which enteric virus is known for causing paralytic disease?
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Parvovirus B19 can lead to hydrops fetalis in which trimester?
Parvovirus B19 can lead to hydrops fetalis in which trimester?
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What is the genome type of Norovirus?
What is the genome type of Norovirus?
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What common feature is shared among the enteric tract viruses listed?
What common feature is shared among the enteric tract viruses listed?
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What clinical finding is most commonly associated with Rotavirus infection?
What clinical finding is most commonly associated with Rotavirus infection?
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Which statement is true regarding treatment options for Human Herpesvirus 6 in immunocompetent children?
Which statement is true regarding treatment options for Human Herpesvirus 6 in immunocompetent children?
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Which of the following viruses is responsible for causing the 'slapped cheek syndrome'?
Which of the following viruses is responsible for causing the 'slapped cheek syndrome'?
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What is the primary mode of transmission for Parvovirus B19?
What is the primary mode of transmission for Parvovirus B19?
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What is the most significant clinical outcome associated with Parvovirus B19 infection in the second trimester of pregnancy?
What is the most significant clinical outcome associated with Parvovirus B19 infection in the second trimester of pregnancy?
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Which of the following viral families does Norovirus belong to?
Which of the following viral families does Norovirus belong to?
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Which of the following viruses is NOT associated with a vaccine for prevention?
Which of the following viruses is NOT associated with a vaccine for prevention?
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Which of the following viral families is associated with both Coxsackievirus and Echovirus?
Which of the following viral families is associated with both Coxsackievirus and Echovirus?
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What is the primary function of the viral polymerase in enteric viruses?
What is the primary function of the viral polymerase in enteric viruses?
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Which of the following is a common symptom associated with both Norovirus and Rotavirus infections?
Which of the following is a common symptom associated with both Norovirus and Rotavirus infections?
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What is the primary type of viral genome found in the enteric viruses discussed in the content?
What is the primary type of viral genome found in the enteric viruses discussed in the content?
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Which of these enteric tract viruses is NOT characterized by a naked nucleocapsid?
Which of these enteric tract viruses is NOT characterized by a naked nucleocapsid?
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Flashcards
COVID-19 Immune Response
COVID-19 Immune Response
Infection triggers a cytokine storm, causing respiratory distress.
Histopathology Consequences
Histopathology Consequences
Bilateral alveolar damage with desquamation and fibrin deposits.
Remdesivir
Remdesivir
A drug that inhibits COVID-19 RdRp to stop virus replication.
Nirmatrelvir/Ritonavir
Nirmatrelvir/Ritonavir
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mRNA Vaccines
mRNA Vaccines
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Measles Virus
Measles Virus
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Mumps Virus
Mumps Virus
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Rubella Virus
Rubella Virus
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Parvovirus B19
Parvovirus B19
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Vaccine Types
Vaccine Types
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COVID-19
COVID-19
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SARS-CoV-2
SARS-CoV-2
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Single-stranded RNA
Single-stranded RNA
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ACE2 receptor
ACE2 receptor
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Receptor Binding Domain (RBD)
Receptor Binding Domain (RBD)
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Transmission modes
Transmission modes
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Pathogenicity
Pathogenicity
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Nucleic acid amplification test
Nucleic acid amplification test
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Hand, foot, and mouth disease
Hand, foot, and mouth disease
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Meningitis
Meningitis
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Norovirus
Norovirus
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Viral gastroenteritis
Viral gastroenteritis
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Rotavirus
Rotavirus
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Norovirus Transmission
Norovirus Transmission
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Norovirus Diagnosis
Norovirus Diagnosis
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Norovirus Symptoms
Norovirus Symptoms
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Rotavirus Characteristics
Rotavirus Characteristics
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Rotavirus Diagnosis
Rotavirus Diagnosis
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Rotavirus Symptoms
Rotavirus Symptoms
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Rotavirus Prevention
Rotavirus Prevention
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Enteric Tract Virus Pathogenesis
Enteric Tract Virus Pathogenesis
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Measles
Measles
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Koplik’s spots
Koplik’s spots
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Mumps
Mumps
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Orchitis
Orchitis
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Rubella
Rubella
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Congenital rubella syndrome
Congenital rubella syndrome
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Vaccine
Vaccine
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No antiviral therapy
No antiviral therapy
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Erythema infectiosum
Erythema infectiosum
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Hydrops fetalis
Hydrops fetalis
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Human Herpesvirus 6
Human Herpesvirus 6
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Gastroenteritis
Gastroenteritis
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Poliovirus
Poliovirus
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Coxsackie virus
Coxsackie virus
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Enteric viruses
Enteric viruses
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Study Notes
COVID-19
- COVID-19 is caused by SARS-CoV-2, a severe acute respiratory syndrome coronavirus 2.
- Its genome is single-stranded RNA, enveloped.
- Origins are unknown but likely not the seafood market, possibly animals like bats.
- It's genetically similar to other coronaviruses (SARS-CoV and MERS-CoV).
- The virus infects non-human primates and other animals.
- Genome encodes large proteins that are cleaved into non-structural proteins, crucial for transcription and replication.
- Transmission methods include airborne, transplacental (in some cases), ocular, fecal, and direct contact via fomites.
- Diagnosis involves repeated nucleic acid amplification tests (swabs), chest CT scans, and serologic antibody detection.
COVID-19 Components
- S protein is the viral spike protein of COVID-19.
- TMPRSS2 is a transmembrane protease serine protease 2, found in many tissues, often with ACE2.
- RdRp is the RNA-dependent RNA polymerase of COVID-19.
- 3CLpro is a 3C-like protease, a cysteine protease of COVID-19.
- Endosomes facilitate viral entry and release into host cells (other viruses sometimes enter this way).
COVID-19 Pathogenicity
- SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) receptor in humans, pigs, ferrets, rhesus monkeys, civets, cats, and others.
- The 211-amino acid region RBD binds ACE2, facilitating virus entry.
- Viral replication in the respiratory tract epithelial cells triggers immune response (cytokine storm), leading to respiratory distress, failure, and eventually death if severe.
- Histopathology shows bilateral alveolar damage, desquamation of pneumocytes, fibrin deposits, and exudative inflammation.
COVID-19 Clinical Features
- Age is a major risk factor for severity of COVID-19.
- Most cases start with asymptomatic or mild disease (81%).
- Fever, fatigue and dry cough are typical symptoms.
- Ground-glass opacities and pneumonia can occur.
- Severe cases (14%) involve dyspnea, coexisting illnesses, and intensive care unit (ICU) need.
- Critical disease and death (5%) happen in cases with ARDS (acute respiratory distress syndrome), acute cardiac injury, and multi-organ failure. Incubation period is ~5 days. Typical symptom onset is ~8 days and critical/fatal cases will occur at ~16 days
COVID-19 Treatment
- Remdesivir inhibits the COVID-19 RdRp, preventing viral polypeptide proteolysis.
- Nirmatrelvir, in combination with ritonavir (Paxlovid), inhibits SARS-CoV-2 3CLpro cysteine protease and inhibits nirmatrelvir metabolism.
COVID-19 Prevention
- mRNA vaccines (Pfizer-BioNTech, mRNA-1273, Moderna) are available, using mRNA technology to encode COVID spike protein.
- mRNA vaccines are lipid nanoparticle-based and modified mRNA.
- Vaccines are devoid of preservatives, eggs, and latex.
Childhood Viruses
- Measles: Single-stranded, negative-sense RNA, enveloped, helical nucleocapsid, one serotype, spread by respiratory droplets. Symptoms include maculopapular rash and Koplik spots. Complications include encephalitis, deafness, and mental retardation, and increased risk of stillbirth in pregnancy. Live, attenuated vaccine available.
- Mumps: Single-stranded, negative-sense RNA, enveloped, helical nucleocapsid, single serotype, spread by respiratory droplets. Symptoms include salivary gland swelling (parotid gland). Complications include orchitis (in males), and typically benign meningitis, potentially leading to sterility if bilateral orchitis is severe. Live, attenuated vaccine available.
- Rubella: Single-stranded, positive-sense RNA, lipoprotein envelope, icosahedral nucleocapsid, spread by respiratory droplets and transplacentally. Features include maculopapular rash. Complications include intrauterine growth retardation, hepatosplenomegaly, congenital heart defects (patent ductus arteriosis, pulmonary stenosis), cataracts, sensorineural hearing loss, thrombocytopenic purpura, and mental retardation. Live, attenuated vaccine available.
- Parvovirus B19: Small, nonenveloped, single-stranded DNA, negative-strand, icosahedral nucleocapsid, one serotype, respiratory route or transplacental. Features include erythema infectiosum ("fifth disease"), slapped cheek syndrome, and aplastic anemia. Symptoms can vary in severity from asymptomatic to potentially serious outcomes like hydrops fetalis (severe fetal edema). No antiviral treatment.
- Human Herpesvirus 6: High fever and rapid-onset rash. Infection of B & T cells, often latent, potential for complicated in immunocompromised patients (pneumonia, hepatitis, encephalitis). May be transmitted via saliva, nasal secretions, or sexual contact. No antiviral treatment for immunocompetent patients.
Enteric Tract Viruses
- Norovirus: Nonenveloped, single-stranded RNA, fecal-oral transmission, watery diarrhea, vomiting, headaches, typically mild, not entirely understood mechanism, resistant to desiccation, chlorination.
- Rotavirus: Double-stranded RNA, usually causing severe diarrhea in infants and young children. Fecal-oral transmission. Vaccination available (Rotarix, RotaTeq).
- Poliovirus: Single-stranded RNA, causing paralysis and death in cases of poliomyelitis. Fecal-oral transmission. Vaccination available.
- Coxsackievirus: Single-stranded RNA, causing hand-foot-and-mouth disease, hemorrhagic conjunctivitis, meningitis (multiple serotypes). Fecal-oral transmission. No specific antiviral treatment.
- Echovirus: Single-stranded RNA, often causing meningitis, aseptic meningitis. Fecal-oral transmission. No specific antiviral treatment.
Studying That Suits You
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Description
Test your knowledge on the viruses causing COVID-19 and Norovirus. This quiz covers various aspects, including transmission methods, viral structure, and clinical impacts of these pathogens. Perfect for students studying virology or anyone interested in understanding these viruses better.