Virology Quiz: COVID-19 and Norovirus
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Questions and Answers

What is the name of the virus that causes COVID-19?

  • SARS-CoV
  • HIV
  • MERS-CoV
  • SARS-CoV-2 (correct)
  • How is SARS-CoV-2 transmitted?

  • Only through direct contact with an infected person
  • Through airborne particles
  • Through contaminated surfaces
  • All of the above (correct)
  • What is the role of ACE2 in the COVID-19 infection process?

  • ACE2 is a protein that helps the virus enter the cell (correct)
  • ACE2 is a protein that helps the virus replicate
  • ACE2 is a protein that helps the virus spread to other cells
  • ACE2 is a type of antibody that fights the virus
  • What is the function of the RBD region of the viral spike protein?

    <p>The RBD region helps the virus attach to the host cell (D)</p> Signup and view all the answers

    Which of the following is NOT a component of SARS-CoV-2?

    <p>DNA polymerase (B)</p> Signup and view all the answers

    Which of the following methods can be used to diagnose COVID-19?

    <p>All of the above (D)</p> Signup and view all the answers

    Where does SARS-CoV-2 replication occur in the body?

    <p>Respiratory tract epithelial cells (D)</p> Signup and view all the answers

    What is the role of endosome in SARS-CoV-2 infection?

    <p>It helps the virus enter the cell (C)</p> Signup and view all the answers

    What is the primary mode of transmission for Norovirus?

    <p>Fecal-oral route from contaminated food or water (C)</p> Signup and view all the answers

    Which of the following statements is true regarding Norovirus?

    <p>It can be excreted in stool before symptoms appear. (C)</p> Signup and view all the answers

    What are common clinical effects associated with viral infections in the gastrointestinal tract?

    <p>Osmotic (secretory) diarrhea (D)</p> Signup and view all the answers

    Which virus is the most common cause of viral gastroenteritis in children?

    <p>Rotavirus (C)</p> Signup and view all the answers

    What distinguishes Norovirus from bacterial infections in terms of severity?

    <p>Viral infections typically cause less severe effects. (A)</p> Signup and view all the answers

    What is the primary cause of the maculopapular rash seen in measles infections?

    <p>Immune response from cytotoxic T cells (A)</p> Signup and view all the answers

    Which of the following features is NOT associated with mumps virus?

    <p>Positive-sense RNA genome (A)</p> Signup and view all the answers

    What serious complication can mumps cause in postpubertal males?

    <p>Orchitis (A)</p> Signup and view all the answers

    Which of the following statements about rubella is accurate?

    <p>It can lead to congenital malformations if contracted during the first trimester. (C)</p> Signup and view all the answers

    What is the common method of transmission for measles, mumps, and rubella?

    <p>Respiratory droplets (C)</p> Signup and view all the answers

    What type of vaccine is used for measles, mumps, and rubella prevention?

    <p>Live, attenuated vaccine (A)</p> Signup and view all the answers

    What is a differentiating feature of rubella compared to measles and mumps?

    <p>Lack of virion polymerase (C)</p> Signup and view all the answers

    What defines the viral genome structure of measles and mumps viruses?

    <p>Single-stranded, negative-sense RNA (B)</p> Signup and view all the answers

    What is the diagnosis method for Norovirus infection?

    <p>Stool PCR (B)</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with Rotavirus infection?

    <p>Headaches (A)</p> Signup and view all the answers

    What is the main virulence factor of Norovirus?

    <p>Resistance to chlorination (B)</p> Signup and view all the answers

    What is a common complication resulting from Rotavirus infection?

    <p>Dehydration (C)</p> Signup and view all the answers

    Which of the following vaccines is used for Rotavirus prevention?

    <p>Rotarix (D)</p> Signup and view all the answers

    Which enteric virus binds to the beta-adrenergic receptor during its pathogenesis?

    <p>Rotavirus (B)</p> Signup and view all the answers

    What is the supportive treatment for Norovirus infections?

    <p>Fluids and electrolyte replenishment (D)</p> Signup and view all the answers

    Which of these statements about the incubation period of Rotavirus is true?

    <p>It ranges from 1 to 3 days (B)</p> Signup and view all the answers

    What immediate immune response is triggered by an infection migrating to the alveoli?

    <p>Cytokine storm (B)</p> Signup and view all the answers

    Which consequence is associated with bilateral alveolar damage during a severe infection?

    <p>Desquamation of pneumocytes (B)</p> Signup and view all the answers

    What is the primary mechanism of action for Remdesivir in treating COVID-19?

    <p>Inhibition of COVID-19 RdRp (D)</p> Signup and view all the answers

    What is a key feature of the Pfizer-BioNTech vaccine?

    <p>Encodes COVID spike protein (B)</p> Signup and view all the answers

    Which childhood virus is known for causing lifelong immunity after infection?

    <p>Measles virus (B)</p> Signup and view all the answers

    What type of virus is the Mumps virus classified as?

    <p>Single-stranded negative RNA virus (A)</p> Signup and view all the answers

    What type of viral structure does the Rubella virus possess?

    <p>Icosahedral nucleocapsid (C)</p> Signup and view all the answers

    What kind of treatment is available for parvovirus B19?

    <p>Supportive care only (A)</p> Signup and view all the answers

    Which of the following options describes one of the considerations for Nirmatrelvir/Ritonavir treatment?

    <p>Suitable for mild to moderate COVID-19 (C)</p> Signup and view all the answers

    What stage of immunity is expected after vaccination for Measles and Rubella?

    <p>Lifelong immunity (B)</p> Signup and view all the answers

    What disease is caused by Parvovirus B19?

    <p>Erythema infectiosum (B)</p> Signup and view all the answers

    How is Parvovirus B19 primarily transmitted?

    <p>Respiratory route (B)</p> Signup and view all the answers

    Which of the following is a characteristic of Human Herpesvirus 6?

    <p>Causes rapid onset high fever (A)</p> Signup and view all the answers

    Which enteric virus is known for causing paralytic disease?

    <p>Poliovirus (D)</p> Signup and view all the answers

    Parvovirus B19 can lead to hydrops fetalis in which trimester?

    <p>Second trimester (C)</p> Signup and view all the answers

    What is the genome type of Norovirus?

    <p>Single-stranded RNA; positive sense (D)</p> Signup and view all the answers

    What common feature is shared among the enteric tract viruses listed?

    <p>All contain a RNA genome (B)</p> Signup and view all the answers

    What clinical finding is most commonly associated with Rotavirus infection?

    <p>Watery diarrhea (D)</p> Signup and view all the answers

    Which statement is true regarding treatment options for Human Herpesvirus 6 in immunocompetent children?

    <p>No antiviral drug is available (D)</p> Signup and view all the answers

    Which of the following viruses is responsible for causing the 'slapped cheek syndrome'?

    <p>Parvovirus B19 (A)</p> Signup and view all the answers

    What is the primary mode of transmission for Parvovirus B19?

    <p>Respiratory droplets (A)</p> Signup and view all the answers

    What is the most significant clinical outcome associated with Parvovirus B19 infection in the second trimester of pregnancy?

    <p>Hydrops fetalis (D)</p> Signup and view all the answers

    Which of the following viral families does Norovirus belong to?

    <p>Caliciviridae (C)</p> Signup and view all the answers

    Which of the following viruses is NOT associated with a vaccine for prevention?

    <p>Norovirus (C)</p> Signup and view all the answers

    Which of the following viral families is associated with both Coxsackievirus and Echovirus?

    <p>Picornaviridae (C)</p> Signup and view all the answers

    What is the primary function of the viral polymerase in enteric viruses?

    <p>Replication of RNA (A)</p> Signup and view all the answers

    Which of the following is a common symptom associated with both Norovirus and Rotavirus infections?

    <p>Watery diarrhea (A)</p> Signup and view all the answers

    What is the primary type of viral genome found in the enteric viruses discussed in the content?

    <p>Single-stranded RNA (C)</p> Signup and view all the answers

    Which of these enteric tract viruses is NOT characterized by a naked nucleocapsid?

    <p>Rotavirus (A)</p> Signup and view all the answers

    Flashcards

    COVID-19 Immune Response

    Infection triggers a cytokine storm, causing respiratory distress.

    Histopathology Consequences

    Bilateral alveolar damage with desquamation and fibrin deposits.

    Remdesivir

    A drug that inhibits COVID-19 RdRp to stop virus replication.

    Nirmatrelvir/Ritonavir

    Combination drug inhibiting SARS-CoV-2 protease for mild to moderate cases.

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    mRNA Vaccines

    Vaccines using lipid-encapsulated modified RNA to encode spike protein.

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    Measles Virus

    A paramyxovirus causing rash, lifelong immunity; no antiviral treatment available.

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    Mumps Virus

    Paramyxovirus causing swelling, no lifelong immunity; vaccine available.

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    Rubella Virus

    Togavirus that causes congenital malformations; lifelong immunity after vaccination.

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    Parvovirus B19

    A single-stranded DNA virus that causes slapped cheek syndrome.

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    Vaccine Types

    Vaccines for childhood viruses protect against diseases with lifelong immunity.

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    COVID-19

    Disease caused by the SARS-CoV-2 virus, characterized by respiratory symptoms.

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    SARS-CoV-2

    Severe acute respiratory syndrome coronavirus 2, the virus causing COVID-19.

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    Single-stranded RNA

    The type of genome that SARS-CoV-2 possesses, which is necessary for its replication.

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    ACE2 receptor

    The cell surface receptor SARS-CoV-2 binds to for entry into cells.

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    Receptor Binding Domain (RBD)

    The part of the SARS-CoV-2 spike protein that binds to ACE2, facilitating virus entry.

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    Transmission modes

    Ways SARS-CoV-2 spreads, including airborne, transplacental, and contact via fomites.

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    Pathogenicity

    The ability of SARS-CoV-2 to cause disease in host organisms.

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    Nucleic acid amplification test

    A diagnostic test, often using swabs, to detect SARS-CoV-2 infection.

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    Hand, foot, and mouth disease

    A viral disease characterized by vesicular lesions on hands, feet, and mouth.

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    Meningitis

    An infection causing fever, headache, and stiff neck, often due to viruses like echovirus.

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    Norovirus

    A nonenveloped RNA virus, a leading cause of gastroenteritis in adults, transmitted by fecal-oral route.

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    Viral gastroenteritis

    An infection of the stomach and intestines leading to diarrhea and vomiting, less severe than bacterial.

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    Rotavirus

    The most common cause of viral gastroenteritis in children, often leading to severe diarrhea.

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    Norovirus Transmission

    May stay infectious for days in water, uncooked food, and surfaces (fomites).

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    Norovirus Diagnosis

    Diagnosed by stool PCR (Polymerase Chain Reaction) testing.

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    Norovirus Symptoms

    Includes vomiting, headaches, diarrhea; often afebrile (without fever).

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    Rotavirus Characteristics

    Double-stranded RNA virus causing gastroenteritis, especially in children 6-24 months.

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    Rotavirus Diagnosis

    Diagnosed by stool antigen tests or PCR.

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    Rotavirus Symptoms

    Includes mild to moderate fever, vomiting, and frequent watery stools; diarrhea lasts 5-7 days.

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    Rotavirus Prevention

    Prevented by hygiene practices and vaccination (Rotarix, RotaTeq).

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    Enteric Tract Virus Pathogenesis

    Norovirus and Rotavirus primarily affect intestinal mucosal cells, causing dehydration.

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    Measles

    A viral infection causing maculopapular rash and severe complications.

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    Koplik’s spots

    Bright red lesions with a white central dot in the mouth, indicative of measles.

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    Mumps

    A viral infection causing swelling of salivary glands, especially the parotid glands.

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    Orchitis

    Inflammation of the testicles, a complication of mumps.

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    Rubella

    A viral infection known for causing congenital rubella syndrome with malformations.

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    Congenital rubella syndrome

    A condition caused by rubella during pregnancy, leading to serious fetal defects.

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    Vaccine

    A live, attenuated vaccine is used to prevent measles, mumps, and rubella.

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    No antiviral therapy

    No antiviral treatment available for measles, mumps, and rubella infections.

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    Erythema infectiosum

    Also called fifth disease, characterized by a red rash and flu-like symptoms.

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    Hydrops fetalis

    Severe fetal condition caused by B19 infection, leading to massive edema and heart failure.

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    Human Herpesvirus 6

    Virus causing roseola infantum with high fever and rash post-fever.

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    Gastroenteritis

    Inflammation of the stomach and intestines, resulting in diarrhea and vomiting.

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    Poliovirus

    Virus that can cause poliomyelitis, leading to paralysis by affecting motor neurons.

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    Coxsackie virus

    A type of enteric virus associated with various diseases, including hand-foot-and-mouth disease.

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    Enteric viruses

    Viruses transmitted via fecal-oral route, including Norovirus and Poliovirus.

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    Study Notes

    COVID-19

    • COVID-19 is caused by SARS-CoV-2, a severe acute respiratory syndrome coronavirus 2.
    • Its genome is single-stranded RNA, enveloped.
    • Origins are unknown but likely not the seafood market, possibly animals like bats.
    • It's genetically similar to other coronaviruses (SARS-CoV and MERS-CoV).
    • The virus infects non-human primates and other animals.
    • Genome encodes large proteins that are cleaved into non-structural proteins, crucial for transcription and replication.
    • Transmission methods include airborne, transplacental (in some cases), ocular, fecal, and direct contact via fomites.
    • Diagnosis involves repeated nucleic acid amplification tests (swabs), chest CT scans, and serologic antibody detection.

    COVID-19 Components

    • S protein is the viral spike protein of COVID-19.
    • TMPRSS2 is a transmembrane protease serine protease 2, found in many tissues, often with ACE2.
    • RdRp is the RNA-dependent RNA polymerase of COVID-19.
    • 3CLpro is a 3C-like protease, a cysteine protease of COVID-19.
    • Endosomes facilitate viral entry and release into host cells (other viruses sometimes enter this way).

    COVID-19 Pathogenicity

    • SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) receptor in humans, pigs, ferrets, rhesus monkeys, civets, cats, and others.
    • The 211-amino acid region RBD binds ACE2, facilitating virus entry.
    • Viral replication in the respiratory tract epithelial cells triggers immune response (cytokine storm), leading to respiratory distress, failure, and eventually death if severe.
    • Histopathology shows bilateral alveolar damage, desquamation of pneumocytes, fibrin deposits, and exudative inflammation.

    COVID-19 Clinical Features

    • Age is a major risk factor for severity of COVID-19.
    • Most cases start with asymptomatic or mild disease (81%).
    • Fever, fatigue and dry cough are typical symptoms.
    • Ground-glass opacities and pneumonia can occur.
    • Severe cases (14%) involve dyspnea, coexisting illnesses, and intensive care unit (ICU) need.
    • Critical disease and death (5%) happen in cases with ARDS (acute respiratory distress syndrome), acute cardiac injury, and multi-organ failure. Incubation period is ~5 days. Typical symptom onset is ~8 days and critical/fatal cases will occur at ~16 days

    COVID-19 Treatment

    • Remdesivir inhibits the COVID-19 RdRp, preventing viral polypeptide proteolysis.
    • Nirmatrelvir, in combination with ritonavir (Paxlovid), inhibits SARS-CoV-2 3CLpro cysteine protease and inhibits nirmatrelvir metabolism.

    COVID-19 Prevention

    • mRNA vaccines (Pfizer-BioNTech, mRNA-1273, Moderna) are available, using mRNA technology to encode COVID spike protein.
    • mRNA vaccines are lipid nanoparticle-based and modified mRNA.
    • Vaccines are devoid of preservatives, eggs, and latex.

    Childhood Viruses

    • Measles: Single-stranded, negative-sense RNA, enveloped, helical nucleocapsid, one serotype, spread by respiratory droplets. Symptoms include maculopapular rash and Koplik spots. Complications include encephalitis, deafness, and mental retardation, and increased risk of stillbirth in pregnancy. Live, attenuated vaccine available.
    • Mumps: Single-stranded, negative-sense RNA, enveloped, helical nucleocapsid, single serotype, spread by respiratory droplets. Symptoms include salivary gland swelling (parotid gland). Complications include orchitis (in males), and typically benign meningitis, potentially leading to sterility if bilateral orchitis is severe. Live, attenuated vaccine available.
    • Rubella: Single-stranded, positive-sense RNA, lipoprotein envelope, icosahedral nucleocapsid, spread by respiratory droplets and transplacentally. Features include maculopapular rash. Complications include intrauterine growth retardation, hepatosplenomegaly, congenital heart defects (patent ductus arteriosis, pulmonary stenosis), cataracts, sensorineural hearing loss, thrombocytopenic purpura, and mental retardation. Live, attenuated vaccine available.
    • Parvovirus B19: Small, nonenveloped, single-stranded DNA, negative-strand, icosahedral nucleocapsid, one serotype, respiratory route or transplacental. Features include erythema infectiosum ("fifth disease"), slapped cheek syndrome, and aplastic anemia. Symptoms can vary in severity from asymptomatic to potentially serious outcomes like hydrops fetalis (severe fetal edema). No antiviral treatment.
    • Human Herpesvirus 6: High fever and rapid-onset rash. Infection of B & T cells, often latent, potential for complicated in immunocompromised patients (pneumonia, hepatitis, encephalitis). May be transmitted via saliva, nasal secretions, or sexual contact. No antiviral treatment for immunocompetent patients.

    Enteric Tract Viruses

    • Norovirus: Nonenveloped, single-stranded RNA, fecal-oral transmission, watery diarrhea, vomiting, headaches, typically mild, not entirely understood mechanism, resistant to desiccation, chlorination.
    • Rotavirus: Double-stranded RNA, usually causing severe diarrhea in infants and young children. Fecal-oral transmission. Vaccination available (Rotarix, RotaTeq).
    • Poliovirus: Single-stranded RNA, causing paralysis and death in cases of poliomyelitis. Fecal-oral transmission. Vaccination available.
    • Coxsackievirus: Single-stranded RNA, causing hand-foot-and-mouth disease, hemorrhagic conjunctivitis, meningitis (multiple serotypes). Fecal-oral transmission. No specific antiviral treatment.
    • Echovirus: Single-stranded RNA, often causing meningitis, aseptic meningitis. Fecal-oral transmission. No specific antiviral treatment.

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    Description

    Test your knowledge on the viruses causing COVID-19 and Norovirus. This quiz covers various aspects, including transmission methods, viral structure, and clinical impacts of these pathogens. Perfect for students studying virology or anyone interested in understanding these viruses better.

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