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Virology: Bunyavirales and Phenuiviridae

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Virology: Bunyavirales and Phenuiviridae

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Questions and Answers

What is the order of the Bunyaviridae family?

Bunyavirales

What is the name of the disease caused by the Phlebovirus of the Phenuiviridae family?

Rift Valley fever (RVF)

How does heating the virus in serum inactivate it?

Heating at 56oC for 40 min

What is the pH range in which the virus is inactivated?

pH < 6.0 Signup and view all the answers

What are some common hosts of the Rift Valley fever virus?

Cattle, Sheep, Goats, and several rodents Signup and view all the answers

How do humans typically contract the Rift Valley fever virus?

Through nasal discharge, blood, vaginal secretions, mosquitoes, or infected meat Signup and view all the answers

What is a major consequence of the Rift Valley fever virus in livestock?

High abortion rates and considerable mortality Signup and view all the answers

Where has the Rift Valley fever virus been reported outside of Africa?

Saudi Arabia Signup and view all the answers

What are the symptoms of Rift Valley Fever in calves?

Fever, Depression, Death (10-70%) Signup and view all the answers

What is the percentage of abortions in adult cattle infected with Rift Valley Fever?

85% Signup and view all the answers

What is the method of virus detection used in laboratory diagnosis of Rift Valley Fever?

RT-PCR assays, notably quantitative RT-PCR Signup and view all the answers

What is the purpose of using IgM-ELISA or HI in laboratory diagnosis of Rift Valley Fever?

Virus identification Signup and view all the answers

What is the duration of immunity conferred by the Live Attenuated Vaccine against Rift Valley Fever?

3 years Signup and view all the answers

What is the drawback of using the Smithburn Neurotropic Strain vaccine in pregnant ewes?

Vaccination resulted in abortion Signup and view all the answers

What is the characteristic of the MP12 Mutagenised Strain vaccine?

Attenuating mutations in each of the three segments of the RVFV genome Signup and view all the answers

What is the characteristic of the Clone 13 of RVFV vaccine?

Large deletion in the gene coding for the nonstructural NSs protein Signup and view all the answers