Bunyaviridae and California Encephalitis Virus Group Quiz
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Questions and Answers

What are the main structural components of Bunyaviridae particles?

  • M, G1, and NSm proteins
  • NSs, NSm, and L protein
  • L, M, and S RNAs (correct)
  • G1 and G2 glycoproteins

Which genus of the Bunyaviridae supergroup is carried by rodents?

  • Bunyavirus
  • Nairovirus
  • Hantavirus (correct)
  • Phlebovirus

What is a distinguishing feature of Bunyaviridae compared to other negative-strand RNA viruses?

  • Enclosed double-stranded RNA genome
  • Circular genome segments
  • No glycoproteins in the viral envelope
  • Presence of matrix protein (correct)

Where was the tick-borne Heartland phlebovirus discovered in 2012?

<p>United States (B)</p> Signup and view all the answers

What is NOT a characteristic of clinical illness caused by arenaviruses?

<p>Vasculitis (B)</p> Signup and view all the answers

Which symptom is prevalent in patients with Lassa fever?

<p>Pharyngitis (B)</p> Signup and view all the answers

How is an arenavirus infection usually diagnosed?

<p>Serologic and genomic findings (D)</p> Signup and view all the answers

Why are arenaviruses considered too dangerous for isolation?

<p>Because they pose a high risk of infection to laboratory workers (A)</p> Signup and view all the answers

How can rodent-borne arenavirus infections be prevented?

<p>Improving hygiene to limit contact with mice (A)</p> Signup and view all the answers

What is the most appropriate biosafety level for processing samples submitted for arenavirus isolation?

<p>Level 4 (C)</p> Signup and view all the answers

What is the role of mosquitoes in spreading viruses of the California encephalitis virus group?

<p>Spreading aggressive day-biting Aedes triseriatus (B)</p> Signup and view all the answers

What is the main mode of transmission for hantaviruses?

<p>Inhalation of aerosolized rodent urine (B)</p> Signup and view all the answers

During which season did the deadly outbreak of hantavirus pulmonary syndrome (HPS) occur in the Four Corners area of New Mexico?

<p>Spring (B)</p> Signup and view all the answers

What is a characteristic symptom of encephalitis caused by viruses like La Crosse virus?

<p>Headache and fever (C)</p> Signup and view all the answers

Which region has experienced outbreaks of respiratory tract disease caused by viruses of the Sin Nombre subfamily?

<p>Central and South America (C)</p> Signup and view all the answers

What is a common symptom seen in hemorrhagic fevers like Rift Valley fever?

<p>Hematemesis (vomiting blood) (B)</p> Signup and view all the answers

Which laboratory diagnostic method is commonly used to detect bunyaviruses?

<p>Molecular detection using RT-PCR (C)</p> Signup and view all the answers

What is the primary method for preventing human diseases caused by the Bunyaviridae family?

<p>Interrupting contact between humans and the vector (B)</p> Signup and view all the answers

What characteristic helps differentiate Bunyaviridae infections from other viral illnesses?

<p>Mild nonspecific febrile illness (A)</p> Signup and view all the answers

Why did the hantavirus pulmonary syndrome (HPS) outbreak occur in the Four Corners area of New Mexico?

<p>Increased rainfall and rodent population (B)</p> Signup and view all the answers

Which symptom is characteristic of encephalitis caused by viruses like La Crosse virus?

<p>Seizures in 50% of patients (B)</p> Signup and view all the answers

What is a notable feature of hemorrhagic fevers like hemorrhagic fever with renal syndrome (HFRS)?

<p>Petechial rash, systemic hemorrhagic disease, kidney failure (C)</p> Signup and view all the answers

What distinguishes the genera of Bunyaviridae from each other?

<p>All of the above (D)</p> Signup and view all the answers

Where does the Bunyaviridae replicate?

<p>Cytoplasm (D)</p> Signup and view all the answers

How is the virus internalized by cells after interacting with β-integrins?

<p>Endocytosis (C)</p> Signup and view all the answers

What is the role of the G1 glycoprotein in Bunyaviridae replication?

<p>Interacts with β-integrins on cell surface (D)</p> Signup and view all the answers

How do bunyaviruses prime the synthesis of viral mRNAs?

<p>Steal 5′-capped portion of mRNAs in endosomes (D)</p> Signup and view all the answers

Which organelle synthesizes and glycosylates Bunyavirus glycoproteins?

<p>Golgi apparatus (B)</p> Signup and view all the answers

How are Bunyavirus virions released from cells?

<p>Through exocytosis (B)</p> Signup and view all the answers

What is a common pathogenic mechanism shared between Bunyaviridae and togaviruses/flaviviruses?

<p>Transmission by arthropod vectors (C)</p> Signup and view all the answers

What is unique about the transmission of hantaviruses among humans?

<p>By breathing aerosols contaminated with infected urine (C)</p> Signup and view all the answers

What type of infection do hantaviruses cause in rodents?

<p>Chronic asymptomatic infection leading to long-term viral shedding in urine (C)</p> Signup and view all the answers

What is the main effect of hantaviruses on endothelial cells?

<p>Cause vascular permeability and shock (A)</p> Signup and view all the answers

How do most bunyaviruses spread among animals in their life cycle?

<p>Transmitted by infected mosquitoes, ticks, or flies to rodents, birds, and larger animals (C)</p> Signup and view all the answers

How are arthropod vectors controlled?

<p>By eliminating growth conditions for the vectors (D)</p> Signup and view all the answers

What is the average incubation period for arenavirus infections?

<p>10-14 days (D)</p> Signup and view all the answers

How do arenaviruses acquire their envelope?

<p>By budding from the plasma membrane of host cells (C)</p> Signup and view all the answers

Which region is NOT mentioned as a location where arenaviruses are found?

<p>North America (D)</p> Signup and view all the answers

What does the S strand in arenaviruses encode for?

<p>Nucleoprotein and glycoproteins (A)</p> Signup and view all the answers

What is the primary method of spread for arenaviruses to humans?

<p>Contact with infected secretions or body fluids (C)</p> Signup and view all the answers

Which statement about Lymphocytic Choriomeningitis (LCM) is correct?

<p><strong>Meningitis</strong> is a typical clinical event (C)</p> Signup and view all the answers

What is the average incubation period for arenavirus infections?

<p>10-14 days (B)</p> Signup and view all the answers

How do arenaviruses acquire their envelope?

<p>By budding from the plasma membrane of host cells (A)</p> Signup and view all the answers

Which region is NOT mentioned as a location where arenaviruses are found?

<p>North America (A)</p> Signup and view all the answers

What does the S strand in arenaviruses encode for?

<p>Nucleoprotein and glycoproteins (A)</p> Signup and view all the answers

What is the primary method of spread for arenaviruses to humans?

<p>Contact with infected secretions or body fluids (D)</p> Signup and view all the answers

Which statement about Lymphocytic Choriomeningitis (LCM) is correct?

<p>Meningitis is a typical clinical event (B)</p> Signup and view all the answers

Junin and Machupo viruses cause similar syndromes to Lassa fever in which region?

<p>Argentina and Bolivia (A)</p> Signup and view all the answers

What is the primary body site affected by parasites causing human infections?

<p>Intestine (D)</p> Signup and view all the answers

Which type of motility is associated with Flagellates (Mastigophora)?

<p>Flagellate motility (C)</p> Signup and view all the answers

How is Amoebiasis diagnosed?

<p>Detection of cysts in feces (A)</p> Signup and view all the answers

Which organism requires eosinophils to kill due to its multicellular nature?

<p>Helminths (D)</p> Signup and view all the answers

Which parasite is responsible for Giardiasis?

<p>Giardia lamblia (B)</p> Signup and view all the answers

What is the main mode of transmission for Balantidiasis?

<p>Ingestion of cysts (A)</p> Signup and view all the answers

Where does infection by Intestinal Sporozoa primarily occur?

<p>Intestinal epithelium (D)</p> Signup and view all the answers

What is the diagnostic method for Urogenital Flagellate infections?

<p>Trophozites in CSF (A)</p> Signup and view all the answers

Which disease is caused by Naegleria fowleri?

<p>Amoebic meningoencephalitis (A)</p> Signup and view all the answers

What is the main vector for African trypanosomiasis (sleeping sickness)?

<p>Tsetse fly, West Africa (A)</p> Signup and view all the answers

Which form of Leishmania causes the most severe visceral disease?

<p>Leishmania donovanii (D)</p> Signup and view all the answers

What is a characteristic feature of Babesiosis?

<p>Easily confused with malaria (D)</p> Signup and view all the answers

What is the primary host for Toxoplasma gondii?

<p>Cat family (B)</p> Signup and view all the answers

Which disease is caused by Plasmodium spp.?

<p>Malaria (B)</p> Signup and view all the answers

In which host does sporogony occur in Intestinal Sporozoa?

<p>Human definitive host (C)</p> Signup and view all the answers

Which life stage is found in blood plasma in Trypanosoma infections?

<p>Trypomastigote (C)</p> Signup and view all the answers

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