Virology Basics

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Questions and Answers

Viruses are unique microorganisms because they:

  • Replicate independently of a host cell.
  • Synthesize their own proteins using cellular machinery.
  • Possess both DNA and RNA within a single cell.
  • Can produce their own energy through metabolic processes.
  • Require a host cell to replicate their genome. (correct)

Which hepatitis virus utilizes reverse transcriptase during its replication cycle?

  • HBV (correct)
  • HDV
  • HEV
  • HCV
  • HAV

Identify the DNA virus from the following options:

  • HSV (correct)
  • HAV
  • Influenza virus
  • RSV
  • HTLV

Which of the following viruses is classified as an RNA virus?

<p>RSV (A)</p> Signup and view all the answers

The human papillomavirus (HPV) belongs to which viral family?

<p>Papillomaviridae (D)</p> Signup and view all the answers

What specific type of human cells does the influenza A virus primarily target for infection?

<p>Epithelial cells (D)</p> Signup and view all the answers

What is the specific receptor on the host cell that influenza A virus uses to attach and initiate infection?

<p>Sialic acid (C)</p> Signup and view all the answers

Which of the following viruses uniquely replicates within the cytoplasm despite having a DNA genome?

<p>Pox virus (D)</p> Signup and view all the answers

Which route of transmission is most commonly associated with hepatitis A virus (HAV)?

<p>Fecal-oral route (C)</p> Signup and view all the answers

Kaposi's sarcoma, a malignancy often associated with AIDS, is caused by which virus?

<p>HHV8 (E)</p> Signup and view all the answers

Flashcards

Viruses

Microorganisms that lack the capacity to make energy or replicate their genome independently of the host cell and contain only one genomic material (DNA or RNA).

Hepatitis B Virus (HBV)

A unique hepatitis virus that has reverse transcriptase enzyme.

Adenovirus

A family of viruses that can cause pharyngitis, hemorrhagic cystitis and gastroenteritis.

CD4+ T lymphocytes

The main target cell for HIV viruses.

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Respiratory Tract Infection

A virus that transmits via droplets and the airway, causing infections.

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Neurons

The site of latency for HSV 1, HSV 2, and VZV.

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Sialic acid

The receptor that the influenza virus binds to on target cells.

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Pox Virus

A DNA virus that is an exception in terms of replication site.

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Fiber

The protein in adenoviruses that contains viral attachment proteins and has hemagglutinin properties.

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Kaposi Sarcoma

The most notable malignancy to develop in patients with AIDS.

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Study Notes

  • Viruses lack the capacity to make energy or substrates.
  • Viruses cannot make their own proteins.
  • Viruses cannot replicate their genome independently of the host cell.
  • Viruses contain only one genomic material: DNA or RNA.
  • HBV is the unique hepatitis virus with reverse transcriptase enzyme.
  • HSV (Herpes) is a DNA virus.
  • Hepdna, Papilloma (HPU), Herpes (HSV), Adeno, Parvo (B19), Polymo, and Pox are DNA viruses.
  • RSV is an RNA virus.
  • HPV belongs to the Papilloma family, associated with malignant cancers and warts.
  • Adenoviruses can cause pharyngitis, conjunctivitis, and gastroenteritis (40-42).
  • Influenza A virus targets epithelial cells.
  • Sialic acid is the receptor for Influenza A virus.
  • Influenza virus is an exception that replicates itself in the nucleus despite having an RNA genome.
  • Pox virus replicates in the cytoplasm, an exception to DNA viruses replicating in the nucleus.
  • HAV is mainly transmitted via the fecal-oral route.
  • Kaposi sarcoma, is the most notable malignancy to develop in patients with AIDS.
  • HHV-8 causes Kaposi Sarcoma.
  • HHV6 and HHV7 cause roseola (exanthem subitum).
  • Acute HBV infection is indicated by HBAg positivity.
  • Adenovirus causes pharyngitis, haemorrhagic cystitis, and gastroenteritis.
  • The HCV structural antigen is Cor.
  • HCV RNA is the gold standard (confirmative) test for laboratory diagnosis of HCV infections.
  • Respiratory tract infection is mainly caused by viruses transmitting by droplets and airborne routes.
  • Adenovirus serotypes 40, 41, and 42 cause gastroenteritis.
  • The site of latency for HSV 1, HSV 2, and VZV (HSV3) is neurons.
  • HIV virus attaches to target cell receptors via gp120.
  • CD4+ T lymphocytes are the main target cell for HIV viruses.
  • Bifidobacterium longum and Bifidobacterium brevum are members of the Actinobacteria phylum in human gut microbiota.
  • A nucleocapsid in viruses consists of nucleic acid + capsid
  • The function of the fusion protein (F protein) in viruses involves in cell-cell fusion (syncytia formation).
  • Pox virus is a DNA virus exception as it replicates in the cytoplasm.
  • Human Papilloma virus (HPV) is a DNA virus.
  • Adenovirus causes Pharyngoconjunctival fever.
  • Fiber protein in Adenoviruses contains viral attachment proteins and has hemagglutinin properties.
  • Influenza virus is an RNA virus.
  • HHV8 causes Kaposi's sarcoma in AIDS patients.
  • HSV Type 1 and 2 cause infections at mucocutaneous junctions and are a major cause of viral encephalitis.
  • Infectious mononucleosis is NOT a virus that causes maculopapular rash diseases
  • EBV causes infectious mononucleosis
  • VZV causes chickenpox (Varicella)
  • HBV is a DNA hepatitis virus.
  • After percutaneous injury with virus-infected blood, the risk of virus transmission to healthcare personnel is highest to lowest: HBV > HCV > HIV.
  • The HIV viral attachment proteinGp120 interacts with a receptor on the cell.
  • Increased MHC-II expression is NOT one of the immunological pathologies seen in AIDS
  • Fungal cell have a rigid cell wall, and chitin gives rigidity to the fungal cell wall

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