Viral Skin Infections Quiz
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Questions and Answers

What is a prerequisite for a viral skin infection?

  • Contact with other infected animals
  • Intact skin barrier
  • Antropod bite or wound (correct)
  • Immunization against the virus

Which of the following lesions is classified as neoplastic?

  • Vesicular lesions from FMD
  • Ulcers from contagious ecthyma
  • Pustules from poxvirus
  • Papilloma (correct)

What is a characteristic of poxviral infections?

  • Formation of intranuclear inclusion bodies
  • Thickened dermis with fibrosis
  • Development of umbilicated pustules (correct)
  • Presence of flat, raised crusty masses

Which histological feature is associated with poxviral infections?

<p>Multiloculated vesicles (C)</p> Signup and view all the answers

What type of papilloma is specifically mentioned in the context of viral diseases?

<p>Fibropapilloma (A)</p> Signup and view all the answers

What characteristic is observed in the histopathology of contagious ecthyma?

<p>Superficial edema and marked capillary dilatation (D)</p> Signup and view all the answers

What type of lesions are associated with contagious ecthyma?

<p>Vesicles, pustules, and crusts primarily at the feet and oral cavity (A)</p> Signup and view all the answers

What is a notable feature of histopathological findings related to ballooning degeneration?

<p>Intracytoplasmic clear spaces (A)</p> Signup and view all the answers

What type of cells are notably increased in number within the lesions of contagious ecthyma?

<p>Proliferative keratinocytes (A)</p> Signup and view all the answers

What is the typical appearance of lesions during the progression of poxvirus skin lesions?

<p>Sequential phases of vesicles, pustules, and crusts (C)</p> Signup and view all the answers

In the gross examination of contagious pustular dermatitis, what feature is NOT typically observed?

<p>Severe erythema without vesicles (A)</p> Signup and view all the answers

Which histological feature is indicative of infection by certain viruses within keratinocytes?

<p>Intracytoplasmic inclusion bodies (B)</p> Signup and view all the answers

Which histological change is associated with acanthosis in skin lesions?

<p>Increased thickness of the epidermis up to 10x normal (B)</p> Signup and view all the answers

What is a characteristic feature of superficial pyoderma?

<p>Involves the epidermis and usually heals without scarring (D)</p> Signup and view all the answers

Which factor does NOT assist bacteria colonization and invasion of the skin?

<p>Constant desquamation and pressure from normal flora (A)</p> Signup and view all the answers

What type of pyoderma is often chronic and may involve systemic illness?

<p>Deep pyoderma (D)</p> Signup and view all the answers

Which microorganism is commonly associated with impetigo?

<p>Staphylococcus aureus (C)</p> Signup and view all the answers

What clinical appearance can characterize superficial pyoderma?

<p>Erythematous pustules (A)</p> Signup and view all the answers

Which bacterial disease occurs primarily in diseased skin and may involve several bacterial species?

<p>Secondary pyoderma (D)</p> Signup and view all the answers

What usually triggers the formation of vesicles in foot and mouth disease?

<p>Viral infection (B)</p> Signup and view all the answers

What histological feature is associated with superficial pyoderma?

<p>Intraepidermal pustular dermatitis (C)</p> Signup and view all the answers

What is the primary characteristic of canine impetigo?

<p>Formation of pustules and yellow crusty sores (C)</p> Signup and view all the answers

Which of the following is a common cause of canine pyotraumatic dermatitis?

<p>Bacterial infections due to self-trauma (B)</p> Signup and view all the answers

What is the causative agent of 'Diamond Skin Disease' in pigs?

<p>Erysipelothrix rhusiopathiae (A)</p> Signup and view all the answers

What type of dermatitis is characterized by branching filaments and is often seen in hot and humid areas?

<p>Dermatophilosis (D)</p> Signup and view all the answers

What typically predisposes an animal to canine impetigo?

<p>Wet and dirty environments (A)</p> Signup and view all the answers

Which of the following describes the severity of feline acne as it progresses?

<p>Increased pustule formation and inflammation (C)</p> Signup and view all the answers

What kind of infections are caused by Microsporum spp. and Trichophyton spp.?

<p>Superficial mycoses (A)</p> Signup and view all the answers

What is the histological feature associated with sporotrichosis?

<p>Cigar-shaped budding yeast-like organisms (B)</p> Signup and view all the answers

What are the typical clinical manifestations of sporotrichosis?

<p>Single or multiple subcutaneous nodules that ulcerate (A)</p> Signup and view all the answers

What is a common effect of endotoxin-induced venous thrombosis due to Salmonellosis?

<p>Venous infarction of extremities (B)</p> Signup and view all the answers

Which of the following is NOT associated with deep mycoses?

<p>Lichenoid tissue reaction (B)</p> Signup and view all the answers

What type of fungi primarily cause subcutaneous or intermediate mycoses?

<p>Saprophytic fungi (A)</p> Signup and view all the answers

What is observed through the PAS stain in cases of sporotrichosis?

<p>Marked fibrosis around granulomatous infiltrate (D)</p> Signup and view all the answers

What is the primary characteristic appearance of lesions caused by dermatophytosis?

<p>Circular patches of scaling and alopecia (C)</p> Signup and view all the answers

Which of the following factors predisposes animals to dermatophytosis?

<p>Overcrowding and poor sanitation (A)</p> Signup and view all the answers

What is a common cause of alopecia in dermatophytosis?

<p>Breakage of brittle hair (C)</p> Signup and view all the answers

What type of fungi is primarily associated with dermatophytosis?

<p>Microsporum and Trichophyton (D)</p> Signup and view all the answers

What histological feature is associated with the early phase of contact irritant dermatitis in dermatophytosis?

<p>Acanthosis (epidermal hyperplasia) (C)</p> Signup and view all the answers

Where can arthrospores be found in cases of dermatophytosis?

<p>Surrounding the hair shaft (C)</p> Signup and view all the answers

What is the mechanism by which dermatophytes affect hair follicles?

<p>Growing only in keratinized portions, causing a breakage (D)</p> Signup and view all the answers

What can result from secondary bacterial folliculitis due to dermatophytosis?

<p>Permanent destruction of hair roots (B)</p> Signup and view all the answers

Flashcards

How do viruses infect the skin?

Viral infections of the skin can occur when the skin barrier is compromised, allowing viruses to enter.

What are papillomaviruses?

Papillomaviruses are a group of viruses that cause skin growths called papillomas. They are epitheliotropic, meaning they infect epithelial cells, which are the cells that line surfaces, including skin.

Describe the progression of poxvirus lesions.

Poxviruses cause skin lesions that progress through different stages: erythema (redness), papules (raised bumps), vesicles (fluid-filled blisters), pustules (pus-filled blisters), ulceration, and crust formation. The healing process often leaves scars.

What are papillomas?

Papillomas are neoplastic lesions, meaning they involve abnormal cell growth. They are caused by papillomaviruses and can be flat, raised, crusty, fissured, or horny.

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What are the characteristics of poxvirus infections?

Poxvirus infections are proliferative, meaning they involve rapid cell growth. The lesions are characterized by epidermal swelling, vacuolation (formation of spaces within cells), and multiloculated vesicles (blisters with many compartments).

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Ballooning Degeneration

A distinctive characteristic of poxvirus infection where cells swell up and develop tiny cavities within them.

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Intracytoplasmic Inclusion Bodies

Small, dense structures found inside infected cells that contain viral DNA or RNA.

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Poxvirus Lesions

A type of skin infection caused by poxviruses, often characterized by the progression of lesions through different stages: vesicles (fluid-filled blisters), pustules (pus-filled blisters), and crusts.

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Hyperkeratosis

A thickening of the outermost layer of skin (epidermis) due to increased cell proliferation. Often seen in poxvirus infections.

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Spongiosis

A characteristic feature of contagious ecthyma, where the epidermis shows a spongy appearance with spaces between cells.

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Contagious Ecthyma

A skin infection, also known as contagious pustular dermatitis, caused by the Orf virus.

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Acanthosis

A type of abnormal cell growth characterized by an increase in the thickness of the epidermis.

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Intracytoplasmic Inclusion Bodies

Small, round structures that are found inside infected cells and contain viral proteins. These inclusions are often brightly colored when viewed under a microscope.

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Skin Barrier Resistance

Refers to the remarkable resistance of intact skin to bacterial invasion due to factors like dryness, constant shedding of skin cells, and the presence of normal flora.

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Damaged Skin Barrier and Bacterial Infections

When the skin barrier is damaged, bacteria from the transient or resident flora on the skin can become pathogenic, causing infections.

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Moisture and Bacterial Colonization

Persistent moisture on the skin, leading to softening and breakdown of the outermost layer (stratum corneum) and loss of the protective lipid coat, increases bacterial colonization and infection.

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Keratinization Alterations and Bacterial Infections

Conditions or alterations that disrupt the normal process of skin cell development and shedding can increase bacterial susceptibility.

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Friction, Parasites, and Bacterial Infection

Physical damage to the skin, such as irritation from parasites, excessive rubbing, or trauma, can create entry points for bacteria.

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Pyoderma: Bacterial Skin Infection

Pyoderma is a general term for bacterial infections of the skin, ranging from superficial to deep.

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Superficial Pyoderma

Superficial pyoderma affects only the epidermis, often heals without scarring, and doesn't usually cause systemic illness.

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Deep Pyoderma

Deep pyoderma involves the dermis and sometimes the subcutaneous layer, often scars, can be chronic, and may affect the lymph nodes and overall health.

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What are superficial mycoses?

Superficial mycoses are fungal infections that mainly affect the outermost layers of the skin, such as the stratum corneum, hair follicles, and hair shafts.

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What is the classic lesion seen in superficial mycoses?

A characteristic feature of superficial mycoses is the circular patch of alopecia with expanding edges and central healing, creating a ring-like appearance.

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What is Dermatophytosis?

Dermatophytosis, also known as ringworm, affects the keratinized layers of the skin, hair, and nails, causing inflammation.

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What are the common causative agents of Dermatophytosis?

Microsporum and Trichophyton are the common dermatophyte genera seen in young and immunocompromised animals. The infection spreads through direct contact, infected animals, or contaminated objects.

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What are the clinical signs of Dermatophytosis?

Dermatophytosis can manifest as circular patches of scaling and alopecia, sometimes progressing to papules, pustules, furunculosis, and crusting.

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What is a common manifestation of Dermatophytosis in canine patients?

Dermatophytosis can affect various body parts, but one common manifestation is focal alopecia, erythema, and scaling on the canine pinna.

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What are the clinical signs of Dermatophytosis in cattle?

Dermatophytosis in cattle is characterized by multifocal alopecia with scaling and crusting, often observed on the head.

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Can Dermatophytosis affect humans?

Dermatophytosis can affect humans. Exposure to infected animals, even if asymptomatic, increases the risk of contracting the infection.

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Canine Impetigo

A bacterial skin infection in dogs characterized by pustules and yellow crusty sores. It is often triggered by moisture, dirt, abrasions, parasites, or poor nutrition.

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Dermatophilosis in Ruminants

A superficial exudative dermatitis in ruminants, primarily observed in hot and humid environments.

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Diamond Skin Disease in Pigs

A bacterial disease that causes a characteristic skin lesion in pigs with a rhomboid or diamond shape. It's a result of infection with Erysipelothrix rhusiopathiae.

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Canine Pyotraumatic Dermatitis

A condition where the skin is severely irritated and the animal scratches excessively, leading to wounds and secondary bacterial infections. Symptoms include hair loss, scratches, and oozing sores.

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Feline Acne

A common bacterial skin infection in cats caused by bacteria colonizing hair follicles. It manifests as small blackheads or pustules, particularly on the chin.

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Salmonellosis or Other Endotoxemias

A bacterial disease often caused by Salmonella or other bacteria that produce endotoxins. This can lead to blood clots in the veins of the extremities, causing tissue death.

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Superficial Mycoses

A type of fungal infection that affects only the outer, non-living layers of skin.

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Dermatomycosis (Dermatophytosis)

A fungal infection of the skin caused by Microsporum spp. and Trichophyton spp. It primarily affects the non-living, outermost layer of skin.

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What is Sporotrichosis?

Sporotrichosis is a subcutaneous infection caused by the fungus Sporothrix schenkii, typically entering through skin wounds. It causes nodules that often ulcerate, discharging a thick, red-brown exudate. Healing is slow.

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What are the microscopic features of Sporotrichosis?

Microscopically, Sporotrichosis is characterized by intense pyogranulomatous dermatitis with numerous cigar-shaped or oval budding yeast-like organisms within macrophages. These organisms are typically pink-stained and can be found intracellularly, extracellularly, or in microabscesses.

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What are Deep Mycoses?

Deep mycoses are fungal infections caused by saprophytic fungi that primarily enter the body through inhalation or skin penetration. Examples include Cryptococcosis and systemic Sporotrichosis. They manifest as nodules, ulcers, fistulas, and abscesses.

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What are the histologic features of Deep Mycoses?

Histologically, Deep Mycoses show granulomatous or pyogranulomatous dermatitis and can involve subcutaneous fat (panniculitis). These changes often accompany systemic fungal disease.

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What are Subcutaneous Mycoses?

Subcutaneous mycoses are caused by saprophytic fungi that gain entry into the body through penetrating skin wounds. These infections primarily involve the subcutaneous tissues.

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Study Notes

Integumentary System: Lecture 5

  • Viral Diseases of Skin (5.1):

    • Intact skin is resistant to viral entry.
    • Infection often requires an entry point (e.g., insect bite, wound).
    • Viral infections can be local (e.g., papillomas) or systemic (e.g., viremia).
    • Viral skin infections include poxviruses, papillomaviruses (causing papillomas), foot-and-mouth disease (FMD), canine distemper, and vesicular exanthema.
    • Lesion types include neoplastic (e.g., papilloma), proliferative (e.g., poxvirus), and vesicular (e.g., FMD).
  • Papilloma Virus:

    • Gross: lesions appear flat, raised, crusty, fissured, horny masses, attached to skin via narrow/broad pedicles.
    • Histology: shows epidermal and dermal proliferation, marked epidermal thickening (hyperplasia), altered keratin layers, and sometimes inclusion bodies (rarely intracellular/extracellular).
    • Types include squamous and fibropapilloma.
  • Pox Viral Infections:

    • Gross: erythematous macules, papules, vesicles, pustules, ulcers, crusts, scars.
    • Histology: epidermal cytoplasmic swelling, vacuolation, multiloculated vesicles, dermal edema, vascular dilation, perivascular mononuclear-cell infiltrate, variable neutrophil infiltrate.
    • Different stages may show different characteristics: vesicles, pustules, crusts, and sometimes hyperplastic/proliferative lesions.
    • Could be colonized by surface bacteria and show intracytoplasmic inclusion bodies.
  • Contagious Ecthyma:

    • AKA Contagious Pustular Dermatitis
    • Gross: skin abrasions, transient vesicles, pustules, and brown-gray crusts.
    • Histology: marked keratinocyte proliferation (acanthosis), vacuolation/spongiosis, intraepidermal microabscesses, and intracytoplasmic inclusion bodies.
    • Dermal changes include superficial edema, marked capillary dilation, and perivascular mononuclear infiltration.
    • Lesions are generally located at feet, oral cavity areas, and eyelids.
  • Foot and Mouth Disease:

    • Gross: displays vesicular lesions and erosive lesions on skin and oral mucosa.
    • Histo: shows epithelial degeneration and necrosis, particularly affecting the stratum spinosum, inflammation, necrosis, and edema.
  • Vesicular Exanthema:

    • Vesicles appear on snout, oral mucosa, soles of feet, coronary band, and between toes.
  • Canine Distemper:

    • Clinical sign includes scaling/crusts on distal limbs.
  • Bacterial Diseases of Skin (5.2):

    • Normal skin is resistant to bacterial invasion due to dryness, desquamation, and normal flora pressures.
    • Damage to the skin barrier allows bacteria from transient or resident flora to cause infection.
    • Factors that increase bacterial colonization and invasion include prolonged moisture, altered keratinization, physical damage, parasites, dirt, and excessive sweating.
  • Pyoderma:

    • Secondary skin condition, frequently caused by multiple bacteria species, showing varied skin appearance, including variable clinical signs and ectoparasitism/seborrheic conditions.
    • Superficial pyoderma is often epidermis-restricted, not systemic, with a short duration and no scarring.
    • Lesions include papules, transient pustules, crusts, intraepidermal or superficial folliculitis.
    • Examples include impetigo (Staph. aureus), and dermatophilosis.
  • Deep Pyoderma:

    • Involves deeper skin layers frequently associated with chronic courses, scarring, and systemic illness.
    • Lesions include papules, pustules, subcutaneous nodules, abscesses, or ulcers.
    • Histological changes may include deep folliculitis, nodular/diffuse suppurative or pyogranulomatous dermatitis.
    • Examples include feline leprosy (Mycobacterium lepraemurium) and footrot (Fusobacterium necrophorum).
  • Canine Impetigo:

    • A bacterial skin infection resulting in pustules and yellow crusty sores.
    • Predisposed by moisture, abrasions, parasitism, and poor nutrition.
    • Clinically manifested as superficial pustular dermatitis.
    • Characterized by epidermal ulceration and inflammation, and likely neutrophil infiltration.
  • Dermatophilosis:

    • Superficial exudative dermatitis, often seen in hot, humid climates (ruminants).
  • Feline Acne:

    • Bacterial infection of hair follicles in telogen (resting phase).
    • Characteristic lesions include acanthosis, inflammation, pustule formation, and comedo (obstructed follicle).
  • Canine Pyotraumatic Dermatitis:

    • Secondary bacterial infection of self-traumatized skin.
    • Characterized by intense pruritus, self-trauma, focal alopecia, excoriation, ulceration, and exudative lesions.
  • Swine Erysipelas:

    • Presents as diamond-shaped erythematous plaques, characteristic of the infection.
  • Salmonellosis/Endotoxemias:

    • Venous infarction of extremities is a common sign, due to endotoxin-induced venous thrombosis.
  • Mycotic Diseases (5.3):

    • Superficial mycoses: growth restricted to keratinized tissue (e.g., dermatophytosis/ringworm).
    • Dermatophytosis: the fungus (like _Microsporum spp._and Trichophyton spp.) doesn't invade living tissues, but colonies localized on keratinized skin structures, causing lesions including alopecia, scaling, papules, pustules, and sometimes furunculosis/crusting.
    • Deep Mycoses: characterized by the organisms spreading into subcutaneous layers (e.g. Cryptococcus species).
  • Sporotrichosis:

    • A subcutaneous mycosis presenting as skin and cutaneous tissue lesions, forming single/multiple nodules, which ulcerate and discharge thick red-brown exudate. Often heals slowly and deeply.

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Test your knowledge on viral skin infections, including characteristics and histological features of various lesions. This quiz covers topics such as poxviral infections, contagious ecthyma, and neoplastic lesions. Perfect for students and professionals in the field of dermatology and infectious diseases.

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