Podcast
Questions and Answers
What is the primary function of the hemagglutinin protein in Influenza A virus?
What is the primary function of the hemagglutinin protein in Influenza A virus?
Which of the following is NOT a characteristic of Oseltamivir?
Which of the following is NOT a characteristic of Oseltamivir?
What is the main mechanism of action of Neuraminidase inhibitors?
What is the main mechanism of action of Neuraminidase inhibitors?
What is the duration of treatment with Oseltamivir or Zanamivir?
What is the duration of treatment with Oseltamivir or Zanamivir?
Signup and view all the answers
Which of the following viruses is known to cause pandemics?
Which of the following viruses is known to cause pandemics?
Signup and view all the answers
What is the primary method of administration for Zanamivir?
What is the primary method of administration for Zanamivir?
Signup and view all the answers
Study Notes
Viral Respiratory Tract Infections
- Caused by Influenza A virus, Influenza B virus, and Respiratory Syncytial Virus (RSV)
- Immunization is the preferred approach to prevention
- Antiviral drugs are used in cases of allergies or outbreaks
Influenza A Virus
- Can infect a variety of animal hosts
- Causes pandemics (e.g. H1N1)
- Has surface proteins: neuraminidase (N) and hemagglutinin (H)
- H is responsible for attachment, N is responsible for viral release
Antiviral Drugs
- Neuraminidase inhibitors: Oseltamivir and Zanamivir
- Effective against Influenza A and B viruses
- Administered prior to exposure or within 48 hours after onset of symptoms
- 5-day course of treatment
Mechanism of Action (MOA)
- Selectively inhibit neuraminidase, preventing the release of new virions
Pharmacokinetics (PK)
- Oseltamivir: prodrug, administered orally, activated by hepatic esterases
- Zanamivir: active, administered via inhalation
- Both excreted in the urine
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Learn about the causes and prevention of viral respiratory tract infections, including influenza A and B viruses, RSV, and immunization approaches.
