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Questions and Answers
What occurs during the protein synthesis of a virus?
What occurs during the protein synthesis of a virus?
How are mature nucleocapsids formed in viruses?
How are mature nucleocapsids formed in viruses?
Which of the following best describes the transmission of Dengue virus?
Which of the following best describes the transmission of Dengue virus?
What happens during the viremia phase of Dengue virus infection?
What happens during the viremia phase of Dengue virus infection?
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What type of genetic material do adenoviruses have?
What type of genetic material do adenoviruses have?
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What is the function of hexon proteins in adenoviruses?
What is the function of hexon proteins in adenoviruses?
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Study Notes
Protein Synthesis
- Newly synthesized viral RNA genomes are assembled into viral RNA, including structural proteins.
Assembly
- Viral genomes and capsid proteins assemble together into mature nucleocapsids through the endoplasmic reticulum (ER) membrane.
- Host cell acquires envelope by exocytosis.
Pathogenesis of Dengue Virus
- Dengue virus is primarily transmitted to humans through the bite of infected mosquitoes.
- Virus enters the body and targets immature cells.
- Viremia occurs, where the virus circulates in the bloodstream, usually within 4-10 days after infection.
- Dengue symptoms include widespread infection, high fever, severe headache, eye pain, joint muscle pain, rash, and mild bleeding.
Adenovirus
- Adenoviruses are medium-sized (90-100 nm), non-enveloped viruses with double-stranded DNA.
- There are more than 50 types of distinct adenoviruses that can cause infections in humans.
- The capsid is composed of protein subunits called capsomeres.
- Hexon proteins are the most distinct adenovirus proteins.
Adenovirus Replication
- Attachment: Adenovirus attaches to specific receptors on a host cell.
- Entry: The virus gets engulfed by the host cell into an endosome.
- Genome: The genome is likely encoded by more than 50 distinct adenoviruses.
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Description
Explore the process of viral replication, including protein synthesis and assembly, and the pathogenesis of Dengue virus.
