Viral Infections and Replication Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What occurs during a productive infection?

  • Infecting virus is always defective.
  • The viral genome is absent in host cells.
  • All viral genes are expressed and infectious virus is produced. (correct)
  • The host immune response is fully activated.

What is the main characteristic of an abortive infection?

  • Establishing latent infection in host cells.
  • Expression of all viral genes.
  • Production of infectious progeny fails. (correct)
  • Complete viral replication and production.

What differentiates latent infection from chronic infection?

  • Chronic infections have minimal or absent viral gene replication.
  • Latent infections do not involve viral genome replication or virion production. (correct)
  • Latent infections lead to immediate immune response activation.
  • Latent infection produces more virions than chronic infection.

What is the purpose of latent genes during latency?

<p>To prevent host immune response and maintain the virus in the host. (D)</p> Signup and view all the answers

What happens at the end of the latent period for a virus?

<p>Marked disorder of cell function and changes in morphology occur. (D)</p> Signup and view all the answers

Which factor is NOT associated with latent infection?

<p>Continuous replication of the viral genome. (D)</p> Signup and view all the answers

Why might a virus undergo an abortive infection?

<p>The host cell is in a nonpermissive state. (B)</p> Signup and view all the answers

What is one consequence of latent infection for the host?

<p>Intracellular viral persistence without producing infectious virus. (C)</p> Signup and view all the answers

What is the primary characteristic of cytopathic effect (CPE)?

<p>Lysis and death of cells (C)</p> Signup and view all the answers

Which viral replication step involves the removal of capsid proteins?

<p>Uncoating (A)</p> Signup and view all the answers

Which of the following is NOT typically observed as a change in CPE?

<p>Enhanced cell division (D)</p> Signup and view all the answers

What role does pH play in the viral life cycle during penetration?

<p>Favors uncoating (C)</p> Signup and view all the answers

What is the result of viral genome replication during the viral growth cycle?

<p>Assembly of complete virus particles (B)</p> Signup and view all the answers

Which step follows immediately after the uncoating of the viral genome?

<p>Gene expression (C)</p> Signup and view all the answers

What type of cells do viruses typically target to induce CPE?

<p>Eukaryotic cells (C)</p> Signup and view all the answers

Which of the following events is classified as a late event in viral replication?

<p>Release (B)</p> Signup and view all the answers

What is the term used to describe the types of cells and tissues in which a virus can replicate?

<p>Tropism (B)</p> Signup and view all the answers

Which type of virus typically uses the host cell's RNA polymerase for mRNA synthesis?

<p>Most DNA viruses (D)</p> Signup and view all the answers

Which of the following viruses can infect only human cells?

<p>Poliovirus (B)</p> Signup and view all the answers

What types of proteins are synthesized as early proteins during viral replication?

<p>Enzymes required for replication (D)</p> Signup and view all the answers

Which of the following statements about the viral genome is correct?

<p>All DNA viruses consist of double-stranded DNA except for parvoviruses. (C)</p> Signup and view all the answers

During which phase do the components of the virus assemble into complete virions?

<p>Maturation (A)</p> Signup and view all the answers

What generally happens during the release of new virions from host cells?

<p>It may or may not kill host cells. (B)</p> Signup and view all the answers

What specific receptor does the rabies virus attach to for entry into the host cell?

<p>Acetylcholine receptor (B)</p> Signup and view all the answers

What is the term used for viruses that infect bacteria?

<p>Bacteriophages (B)</p> Signup and view all the answers

What characterizes the eclipse period during viral replication?

<p>Loss of measurable infectivity (D)</p> Signup and view all the answers

How long does it typically take for a single virion to replicate within a host cell?

<p>Approximately 10 hours (C)</p> Signup and view all the answers

What follows the eclipse period in the viral replication cycle?

<p>Rise period (D)</p> Signup and view all the answers

Which of the following statements is true regarding the yield of infectious virus per cell?

<p>It varies widely, from modest numbers to over 100,000 particles (D)</p> Signup and view all the answers

What is a defining feature of viral multiplication compared to other forms of reproduction?

<p>It can produce hundreds of virus particles from a single initial particle (C)</p> Signup and view all the answers

What is the duration of the virus replication cycle for picornaviruses?

<p>About 6 to 8 hours (A)</p> Signup and view all the answers

What happens to the infecting virion soon after it enters a host cell?

<p>It is disrupted and loses measurable infectivity (C)</p> Signup and view all the answers

Flashcards

Viral Replication

Viruses can only multiply inside living cells, such as bacteria or animal cells. These cells provide the resources, like energy and building blocks, needed for the virus to produce more copies of itself.

Eclipse Period

The stage in viral replication where the infecting virus particle is broken down and its infectiousness disappears. During this phase, the cell's machinery is hijacked to produce viral components.

Viral Growth Cycle

The time taken for a virus to complete its replication cycle, from entering a cell to producing new infectious virus particles.

Bacteriophages

Viruses that infect bacteria.

Signup and view all the flashcards

Rise Period

The period following the eclipse period, where the newly replicated virus particles rapidly accumulate inside the host cell.

Signup and view all the flashcards

Virion

A single virus particle.

Signup and view all the flashcards

Assembly

The process of assembling new virus particles from newly made viral components.

Signup and view all the flashcards

Viral Yield

The number of infectious virus particles produced per cell after the virus replication cycle is complete.

Signup and view all the flashcards

Productive Infection

A type of infection where a virus replicates and produces infectious progeny (new viral particles). This happens in cells that are suitable for viral replication.

Signup and view all the flashcards

Abortive Infection

A viral infection where the virus fails to produce infectious progeny. This can happen because the cell is incompatible with the virus or the virus is damaged.

Signup and view all the flashcards

Latent Infection

A state where a virus exists in a host cell without actively replicating and producing new virus particles. The viral genome is present, but it is not actively replicating.

Signup and view all the flashcards

Permissive Cells

Cells that can support the complete replication cycle of a virus, leading to the production of infectious progeny.

Signup and view all the flashcards

Latent Period

The time period between the initial infection and the appearance of detectable viral particles outside the cell.

Signup and view all the flashcards

Chronic Infection

A type of infection where a virus replicates continuously within a host, often without causing significant symptoms. This differs from latent infection, as viral replication continues.

Signup and view all the flashcards

Latency Genes

Viral genes that are expressed during latency. These genes help the virus persist in the host cell, preventing host cell death and suppressing the immune response.

Signup and view all the flashcards

Reactivation

The process of switching from a latent state to a productive state, where the virus starts actively replicating and producing new virus particles. This often leads to observable symptoms.

Signup and view all the flashcards

Attachment

The process by which a virus binds to a specific receptor protein on the surface of a host cell.

Signup and view all the flashcards

Tropism

The type of cells or organisms that a virus can infect.

Signup and view all the flashcards

Broad Tropism

A virus that can infect a wide range of cells or organisms.

Signup and view all the flashcards

Narrow Tropism

A virus that can only infect a specific type of cell or organism.

Signup and view all the flashcards

Integration

The process by which genetic information from a virus is incorporated into the host cell's DNA.

Signup and view all the flashcards

Replication

The process by which a virus replicates its genetic material within a host cell.

Signup and view all the flashcards

Release

The release of new virus particles from a host cell.

Signup and view all the flashcards

Cytopathic Effect (CPE)

The visible changes within a cell that are caused by a viral infection, usually seen under a microscope. It can be a sign of a virus damaging and killing a host cell, leading to lysis.

Signup and view all the flashcards

Infectious Nucleic Acid

A viral particle that can infect and replicate in a host cell.

Signup and view all the flashcards

Endocytosis

The process where a cell engulfs a substance, often a virus particle, by forming a pocket that pinches off into a vesicle. This is a way for viruses to enter cells.

Signup and view all the flashcards

Uncoating

The removal of a virus's outer protective coat, called the capsid, allowing the viral genetic material to be released inside the host cell, ready to replicate.

Signup and view all the flashcards

Early Proteins

Early proteins that help the virus replicate its genetic material inside the host cell.

Signup and view all the flashcards

Genome Replication

The process by which the virus's genetic material is copied within the host cell, producing more viral DNA or RNA.

Signup and view all the flashcards

Capsid Proteins

Proteins found in the outer structure of a virus, forming its coat.

Signup and view all the flashcards

Progeny Virions

New viruses that are assembled from the replicated genetic material and proteins within the host cell, ready to infect new cells.

Signup and view all the flashcards

Study Notes

Viral Replication

  • Viruses multiply only inside living host cells (bacteria or animal cells)
  • Host cells provide energy and machinery for viral protein and nucleic acid synthesis
  • Viruses that infect bacteria are called bacteriophages
  • Viral replication can be described using a growth curve or a stepwise description of cellular events

Viral Growth Curve

  • Shows the amount of virus produced over time after infection
  • The eclipse period is where no infectious virus is detectable in the infected cells.
  • The rise period follows where there is rapid increase in viral progeny (increase in virus particles in the cell).
  • The eclipse period is a phase of intense synthetic activity within the cell, to support viral needs
  • The duration varies depending on the virus and host cell type.
  • This time varies from minutes to hours

Viral Replication Cycle

  • Attachment and Penetration: The virus attaches to the cell membrane and enters the host cell
  • Uncoating: Viral genome is released from the capsid (protective protein coat).
  • Early Events: Early mRNA and proteins are synthesized which are used to replicate the viral genome.
  • Middle Events: Viral genome replication occurs
  • Late Events: Late mRNA and proteins are then synthesized which are structural capsid proteins
  • Assembly: Progeny virions are assembled
  • Release: Progeny virions are released from the host cell

Types of Viral Infections

  • Productive Infections: Viral genomes replicate inside host cell leading to virus production
  • Abortive Infections: Cell is non-permissive or the infecting virus is defective; no complete progeny virus are made
  • Latent Infections: Minimal viral gene expression occurs; viral genome is present, but no infectious progeny viruses are formed.

Cytopathic Effect (CPE)

  • Cell morphology alterations and function disorder
  • Follows the end of latent period
  • Lysis and death of cells
  • Important diagnostic tool, however, not all viruses cause CPE

Diagnostic Application of CPE

  • Virus growth in cell culture shows CPE, providing a presumptive diagnosis.
  • Change in appearance of infected cells (size, shape, fusion to form multinucleated giant cells)
  • Indication that the virus infected cells are dying or dead.
  • Time taken for CPE, and cell type is important in diagnostic identification

Viral Replication in Eukaryotic Cells

  • Parental virus particle attaches to cell membrane and penetrates
  • Viral genome is uncoated releasing the viral genome
  • Early mRNA and encoded proteins are synthesized for viral genome replication
  • Late mRNA and proteins are synthesized: these are structural capsid proteins
  • Progeny virions are assembled and released from host cell

Viral Genomes

  • Most DNA viruses replicate in the cell nucleus using host cell RNA polymerase to synthesize mRNA. Double-stranded DNA is the genome except for some with single-stranded DNA.
  • Most RNA viruses replicate in the cytoplasm, except for HIV and Influenza virus. Their genomes are typically single-stranded RNA, with some exception for a double stranded RNA genome.

Attachment, Penetration & Uncoating

  • Different means exist for how different viruses enter their host cells, either via endocytosis (engulfing), or fusion of their envelope with host cell membrane
  • The process of uncoating begins within the vesicle formed in endocytosis, influenced by low pH which aids in freeing the nucleic acid
  • Rupture or fusion deposits the viral genomic material into the cytoplasm; this forms the infectious nucleic acid for the virus

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Virus Replication PDF

More Like This

Viral-Host Interaction and Replication of Viruses
35 questions
Introduction to Viruses and Viral Infections
96 questions
Use Quizgecko on...
Browser
Browser