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Viral Infection, Replication and Assembly

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Viral Infection, Replication and Assembly

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Questions and Answers

What is a possible indication of the growth of a virus in inoculated animals?

Changes in animal behavior

Visible lesions (correct)

Enhanced immune system

Increase in animal appetite

Where does monkeypox virus replication occur in infected cells?

Mitochondria

Cytoplasm (correct)

Nucleus

Lysosomes

What is the mechanism of action of cidofovir and brincidofovir in anti-poxvirus treatment?

Blocking viral attachment

Enhancing immune system response

Preventing the formation of the cell-associated enveloped virion

Inhibiting viral DNA polymerase (correct)

What is the primary function of viral mRNA in the virus infection cycle?

To direct the host cell to synthesize viral enzymes and capsid proteins Signup and view all the answers

What is the purpose of VIG in anti-poxvirus therapy?

Preventing virion infection of new cells Signup and view all the answers

What is the unique feature of retroviruses, such as HIV?

They have an RNA genome that must be reverse transcribed into DNA Signup and view all the answers

What is the primary purpose of inoculating viruses in live animals?

To provide living cells for viral replication Signup and view all the answers

What is the role of reverse transcriptase in retrovirus replication?

To transcribe an RNA template to DNA Signup and view all the answers

What is the key event that occurs during step 4 of the poxvirus replication cycle?

Viral DNA replication Signup and view all the answers

How do DNA viruses typically replicate their genome?

Using host cell proteins and enzymes to make additional DNA Signup and view all the answers

What is the classification system developed by David Baltimore based on?

The mode of replication and genome type of the virus Signup and view all the answers

What is the primary difference between DNA and RNA viruses in terms of replication?

DNA viruses use their genome as a template for DNA synthesis, while RNA viruses use their RNA core as a template for RNA synthesis Signup and view all the answers

What is the final stage of the viral replication cycle?

Release of new virions from the host cell Signup and view all the answers

What is the characteristic of viruses that requires them to be inoculated in live animals for replication?

They are obligate intracellular parasites Signup and view all the answers

What is the fate of the viral genome in retrovirus replication?

It is incorporated into the host cell genome Signup and view all the answers

Which of the following types of animals have been used for viral inoculation?

Monkeys, rabbits, guinea pigs, rats, hamsters, and mice Signup and view all the answers

What was the likely first disease for which people tried to prevent by purposely inoculating themselves with other infections?

Smallpox Signup and view all the answers