17 Questions
What is a possible indication of the growth of a virus in inoculated animals?
Visible lesions
Where does monkeypox virus replication occur in infected cells?
Cytoplasm
What is the mechanism of action of cidofovir and brincidofovir in anti-poxvirus treatment?
Inhibiting viral DNA polymerase
What is the primary function of viral mRNA in the virus infection cycle?
To direct the host cell to synthesize viral enzymes and capsid proteins
What is the purpose of VIG in anti-poxvirus therapy?
Preventing virion infection of new cells
What is the unique feature of retroviruses, such as HIV?
They have an RNA genome that must be reverse transcribed into DNA
What is the primary purpose of inoculating viruses in live animals?
To provide living cells for viral replication
What is the role of reverse transcriptase in retrovirus replication?
To transcribe an RNA template to DNA
What is the key event that occurs during step 4 of the poxvirus replication cycle?
Viral DNA replication
How do DNA viruses typically replicate their genome?
Using host cell proteins and enzymes to make additional DNA
What is the classification system developed by David Baltimore based on?
The mode of replication and genome type of the virus
What is the primary difference between DNA and RNA viruses in terms of replication?
DNA viruses use their genome as a template for DNA synthesis, while RNA viruses use their RNA core as a template for RNA synthesis
What is the final stage of the viral replication cycle?
Release of new virions from the host cell
What is the characteristic of viruses that requires them to be inoculated in live animals for replication?
They are obligate intracellular parasites
What is the fate of the viral genome in retrovirus replication?
It is incorporated into the host cell genome
Which of the following types of animals have been used for viral inoculation?
Monkeys, rabbits, guinea pigs, rats, hamsters, and mice
What was the likely first disease for which people tried to prevent by purposely inoculating themselves with other infections?
Smallpox
Learn about the process of viral infection, replication, and assembly, including the steps involved and exceptions to this pattern. Understand how RNA viruses use the RNA core as a template for synthesis and how retroviruses like HIV work.
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