Viral Infection, Replication and Assembly

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Questions and Answers

What is a possible indication of the growth of a virus in inoculated animals?

  • Changes in animal behavior
  • Visible lesions (correct)
  • Enhanced immune system
  • Increase in animal appetite

Where does monkeypox virus replication occur in infected cells?

  • Mitochondria
  • Cytoplasm (correct)
  • Nucleus
  • Lysosomes

What is the mechanism of action of cidofovir and brincidofovir in anti-poxvirus treatment?

  • Blocking viral attachment
  • Enhancing immune system response
  • Preventing the formation of the cell-associated enveloped virion
  • Inhibiting viral DNA polymerase (correct)

What is the primary function of viral mRNA in the virus infection cycle?

<p>To direct the host cell to synthesize viral enzymes and capsid proteins (A)</p> Signup and view all the answers

What is the purpose of VIG in anti-poxvirus therapy?

<p>Preventing virion infection of new cells (D)</p> Signup and view all the answers

What is the unique feature of retroviruses, such as HIV?

<p>They have an RNA genome that must be reverse transcribed into DNA (B)</p> Signup and view all the answers

What is the primary purpose of inoculating viruses in live animals?

<p>To provide living cells for viral replication (C)</p> Signup and view all the answers

What is the role of reverse transcriptase in retrovirus replication?

<p>To transcribe an RNA template to DNA (B)</p> Signup and view all the answers

What is the key event that occurs during step 4 of the poxvirus replication cycle?

<p>Viral DNA replication (A)</p> Signup and view all the answers

How do DNA viruses typically replicate their genome?

<p>Using host cell proteins and enzymes to make additional DNA (A)</p> Signup and view all the answers

What is the classification system developed by David Baltimore based on?

<p>The mode of replication and genome type of the virus (A)</p> Signup and view all the answers

What is the primary difference between DNA and RNA viruses in terms of replication?

<p>DNA viruses use their genome as a template for DNA synthesis, while RNA viruses use their RNA core as a template for RNA synthesis (A)</p> Signup and view all the answers

What is the final stage of the viral replication cycle?

<p>Release of new virions from the host cell (B)</p> Signup and view all the answers

What is the characteristic of viruses that requires them to be inoculated in live animals for replication?

<p>They are obligate intracellular parasites (D)</p> Signup and view all the answers

What is the fate of the viral genome in retrovirus replication?

<p>It is incorporated into the host cell genome (B)</p> Signup and view all the answers

Which of the following types of animals have been used for viral inoculation?

<p>Monkeys, rabbits, guinea pigs, rats, hamsters, and mice (D)</p> Signup and view all the answers

What was the likely first disease for which people tried to prevent by purposely inoculating themselves with other infections?

<p>Smallpox (A)</p> Signup and view all the answers

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