Viral Infection Factors Quiz

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Questions and Answers

What factors can promote viral disease?

  • Poor nutritional status, virulence (correct)
  • Healthy nutritional status, innate immunity
  • Genotype, physicochemical barriers
  • Tropism, adaptive immunity

How does malnutrition affect the body's ability to fight disease?

  • Enhances adaptive immunity
  • Strengthens physicochemical barriers
  • Promotes virion production
  • Makes the immune system less effective (correct)

What can make some individuals more prone to infection and disease?

  • Innate immunity
  • Healthy nutritional status
  • Expression of specific MHC-I alleles (correct)
  • Physicochemical barriers

Do all viral infections result in disease?

<p>Not necessarily (A)</p> Signup and view all the answers

What is the main difference between a productive viral infection and a non-productive or abortive viral infection?

<p>Progeny virions are produced in a productive viral infection. (D)</p> Signup and view all the answers

How can non-productive infections by viruses lead to disease?

<p>By transforming host epithelial cells. (C)</p> Signup and view all the answers

Which virus is an example of a non-productive infection leading to disease?

<p>Human papillomavirus (C)</p> Signup and view all the answers

What can cause disease in immunocompromised hosts in the case of BK virus?

<p>Reactivation of infection in immunocompromised hosts (D)</p> Signup and view all the answers

What is the pathogenesis of cervical carcinoma caused by some human papillomavirus types?

<p>Alteration of host cell cycle regulatory processes (D)</p> Signup and view all the answers

Why do some productive infections only cause disease in immunocompromised hosts?

<p>Reactivation of infection in immunocompromised hosts (A)</p> Signup and view all the answers

What is a crucial requirement for a virus to overcome host defenses?

<p>Avoiding local and systemic antiviral defenses (B)</p> Signup and view all the answers

How can damage occur to the host during a viral infection?

<p>By transforming healthy cells into virally infected cells (D)</p> Signup and view all the answers

What determines the outcome of a viral infection in a host?

<p>The balance between factors that promote disease and those that guard against it (B)</p> Signup and view all the answers

What can lead to direct cell/tissue/organ/system destruction during a viral infection?

<p>Changes in cellular functions/characteristics of virally infected cells (A)</p> Signup and view all the answers

What distinguishes the first pattern of persistent infection from the acute infection?

<p>The pathogen remains and keeps multiplying at a low level (A)</p> Signup and view all the answers

Which virus is an example of a pathogen that remains latent and can reactivate to cause recurring disease?

<p>Human herpesvirus 4 (Epstein-Barr virus) (B)</p> Signup and view all the answers

What characterizes the cyclic, or periodic, disease pattern of infection?

<p>Recurring disease separated by asymptomatic periods (A)</p> Signup and view all the answers

Which virus is an example of a pathogen that causes both varicella (chickenpox) and later in life, zoster (shingles)?

<p>Human herpesvirus 3 (varicella-zoster virus) (A)</p> Signup and view all the answers

Which viruses are typical examples of pathogens with a continuous buildup after recovery leading to recurring disease?

<p>HIV-1, HIV-2, &amp; HTLV-1 (B)</p> Signup and view all the answers

What is characteristic of prion diseases in terms of the accumulation of pathogens?

<p>Continuous buildup in the absence of an acute phase (A)</p> Signup and view all the answers

What is the stage responsible for viral amplification and spread to secondary site(s) of infection?

<p>Incubation period (D)</p> Signup and view all the answers

Which stage is responsible for limiting disease and/or contributing to disease?

<p>Immune responses (A)</p> Signup and view all the answers

When can transmission of a viral disease occur?

<p>Between stage 2 and past stage 7 (C)</p> Signup and view all the answers

Which phase is usually associated with characteristic signs and symptoms of the disease?

<p>Symptomatic phase (A)</p> Signup and view all the answers

In which stage can symptoms linger and wane?

<p>Resolution of disease (B)</p> Signup and view all the answers

What do you call infections that can go completely undetected during some or all of the stages?

<p>Subclinical infections (D)</p> Signup and view all the answers

Which pattern is characterized by the acquisition of a pathogen that multiplies to the extent of causing disease and is then completely eliminated by the host’s immune system?

<p>Acute disease pattern (D)</p> Signup and view all the answers

Which type of infection occurs without overt disease due to the host’s immune system clearing the pathogen prior to the appearance of symptoms?

<p>Asymptomatic infection (B)</p> Signup and view all the answers

What are examples of infections that fall into the category of acute subclinical or asymptomatic infections?

<p>Rhinoviruses, rotaviruses, and noroviruses (B)</p> Signup and view all the answers

What type of progression does Hepatitis B virus present when the acute disease is resolved?

<p>Self-limited, acute progression when the virus is cleared by the host’s immune system (A)</p> Signup and view all the answers

What type of individuals does BK virus cause disease in?

<p>Immunocompromised or immunosuppressed individuals only (D)</p> Signup and view all the answers

Which of the following factors can tip the balance in favor of illness or exacerbate it?

<p>Healthy nutritional status (B)</p> Signup and view all the answers

What is the main outcome of a productive viral infection?

<p>Virion production (B)</p> Signup and view all the answers

Which haplotypes are more prone to infection and disease with some agents than others?

<p>HLA-B0027 or HLA-B0057 MHC-I alleles (D)</p> Signup and view all the answers

What can lead to disease in immunocompromised hosts in the case of BK virus?

<p>Infection or reactivation of the virus (D)</p> Signup and view all the answers

What is the characteristic of infections that fall into the category of acute subclinical or asymptomatic infections?

<p>They are completely undetected during some or all of the stages (C)</p> Signup and view all the answers

What distinguishes the first pattern of persistent infection from the acute infection?

<p>The pathogen is completely eliminated by the immune system in acute infection (B)</p> Signup and view all the answers

What can cause direct destruction to cell/tissue/organ/system during a viral infection?

<p>$Human$ papillomavirus$ infection (A)</p> Signup and view all the answers

What determines whether a viral infection will yield progeny virions or not?

<p>$The$ replicative cycle (B)</p> Signup and view all the answers

What can make it easier for some individuals to get infected and suffer from disease?

<p>Haplotypes, immunodeficiencies (D)</p> Signup and view all the answers

What are the examples of factors guarding from disease?

<p>$Physicochemical$ barriers, behaviors, innate and adaptive immunity, healthy nutritional status, genotype of an individual (B)</p> Signup and view all the answers

What is irrelevant when considering viruses from a viral perspective?

<p>The production of progeny virions (A)</p> Signup and view all the answers

What is one possible outcome from a viral perspective?

<p>The replicative cycle determining the outcome (D)</p> Signup and view all the answers

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