Immunology Quiz on Viral Infection and Response
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Questions and Answers

Which immune cell types are involved in Antibody-dependent cell-mediated cytotoxicity (ADCC)?

  • NK cells, T cells, and neutrophils
  • B cells, macrophages, and neutrophils
  • B cells, T cells, and macrophages
  • NK cells, macrophages, and neutrophils (correct)
  • What type of immunity does IFN-α and β belong to?

  • Cell-mediated Immunity
  • Humoral Immunity
  • Adaptive Immunity
  • Innate Immunity (correct)
  • Which of the following viruses are known to infect T lymphocytes?

  • Epstein-Barr Virus, Adenovirus, HIV
  • Cytomegalovirus, HIV, Epstein-Barr Virus
  • Human T lymphotropic virus (HTLV), Measles virus, HIV (correct)
  • Epstein-Barr Virus, HIV, Measles virus
  • What is the mechanism of action involved in the neutralization of free viruses by antibodies?

    <p>Antibodies block the virus's ability to bind to host cells (D)</p> Signup and view all the answers

    Which of these viruses is known to encode an interferon receptor homolog?

    <p>Vaccinia virus (A)</p> Signup and view all the answers

    Which of these viruses is known to block the transport of MHC class I to the cell surface?

    <p>Adenovirus (D)</p> Signup and view all the answers

    What is the primary role of cytotoxic T lymphocytes (CTLs) in viral immunity?

    <p>Destroying virally infected cells (C)</p> Signup and view all the answers

    Through what mechanism can HIV evade the immune system?

    <p>By infecting macrophages and T lymphocytes (A)</p> Signup and view all the answers

    Which of the following are involved in the innate immune response to viral infection?

    <p>Natural Killer (NK) cells (A), Interferon (IFN) (D)</p> Signup and view all the answers

    What type of immunity is responsible for the long-term resistance to infection after exposure to a pathogen?

    <p>Adaptive immunity (D)</p> Signup and view all the answers

    Which of the following is NOT an example of a virus that can cause human disease?

    <p>Cholera bacteria (C)</p> Signup and view all the answers

    What is the primary function of cytotoxic T lymphocytes (CTL) in the immune response to viral infections?

    <p>Destroying infected cells (D)</p> Signup and view all the answers

    Which type of interferon is primarily involved in the innate immune response to viral infection?

    <p>Type I interferon (IFN-α, β) (A)</p> Signup and view all the answers

    Which of the following is a key characteristic that distinguishes innate immunity from adaptive immunity?

    <p>Innate immunity is specific to a particular pathogen, while adaptive immunity is not. (D)</p> Signup and view all the answers

    Which of these is a consequence of a successful adaptive immune response to a viral infection?

    <p>Development of memory cells that can rapidly respond to future infections with the same virus (A)</p> Signup and view all the answers

    What is the main reason why immune-compromised individuals are more susceptible to infections?

    <p>Their immune system cannot mount a strong enough response to eliminate pathogens efficiently. (C)</p> Signup and view all the answers

    Which of the following statements regarding the 1918 Spanish flu pandemic is CORRECT?

    <p>The pandemic was caused by a new strain of influenza virus. (A)</p> Signup and view all the answers

    What is the primary target of the COVID-19 vaccine?

    <p>The virus's ability to enter human cells (B)</p> Signup and view all the answers

    Which of the following is NOT a mechanism used by the innate immune system to combat bacterial infections?

    <p>Cytotoxic T lymphocyte (CTL) response (D)</p> Signup and view all the answers

    Which of these bacterial strains is commonly found in the gut and often has beneficial functions for human health?

    <p>Escherichia coli (B)</p> Signup and view all the answers

    What is the primary function of pattern recognition receptors (PRRs) in the innate immune response?

    <p>To recognize and bind to pathogen-associated molecular patterns (PAMPs) (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a gram-positive bacterium?

    <p>Presence of a thin peptidoglycan layer (C)</p> Signup and view all the answers

    Which of the following is a key mechanism used by the adaptive immune system to control bacterial infections?

    <p>Phagocytosis mediated by antibody binding (D)</p> Signup and view all the answers

    What is the primary role of cytotoxic T lymphocytes (CTLs) in the immune response to bacterial infections?

    <p>To kill infected cells that harbor intracellular bacteria (B)</p> Signup and view all the answers

    Which of the following is a major characteristic of the adaptive immune response compared to the innate immune response?

    <p>It has the ability to develop memory and improve response upon re-exposure (D)</p> Signup and view all the answers

    What is the main reason that individuals with compromised immune systems are more susceptible to fungal infections?

    <p>Fungal infections are often caused by opportunistic pathogens that typically do not cause disease in healthy individuals (A)</p> Signup and view all the answers

    Which of the following is a key feature of the IgE/Mast cell/Eosinophil response in the immune system's fight against parasites?

    <p>Release of histamine, heparin, and cytokines from mast cells (D)</p> Signup and view all the answers

    Which of the following is NOT a common way that antibodies contribute to the immune response against parasitic infections?

    <p>Activation of cytotoxic T lymphocytes (CTLs) to kill infected cells (D)</p> Signup and view all the answers

    What is the primary reason that there is no effective vaccine for malaria?

    <p>The Plasmodium parasite undergoes a complex life cycle with multiple stages, making it difficult to target with a single vaccine (C)</p> Signup and view all the answers

    Which of the following innate immune mechanisms is NOT directly involved in combating fungal infections?

    <p>Antibody-mediated opsonization (C)</p> Signup and view all the answers

    What is the main reason why individuals with severe neutropenia are more susceptible to fungal infections?

    <p>Neutrophils are the primary phagocytic cells that engulf and destroy fungal pathogens (D)</p> Signup and view all the answers

    Which of the following is considered a normal flora in the human body but can cause opportunistic infections in immunocompromised individuals?

    <p>Candida albicans (C)</p> Signup and view all the answers

    Which of these options is a disease caused by a bacterium found in the gut?

    <p>Food poisoning (from E. coli 0157:H7) (A)</p> Signup and view all the answers

    Which of these is a major factor increasing the risk of fungal infections in individuals with AIDS?

    <p>AIDS patients often experience a decrease in immune cell function, making them susceptible to opportunistic infections (B)</p> Signup and view all the answers

    Flashcards

    Innate Immunity

    The body’s first line of defense against infections, including physical barriers and immune responses like phagocytosis.

    Adaptive Immunity

    A specific immune response that develops over time, involving antibodies and memory cells for long-lasting immunity.

    Immune Memory

    The ability of the immune system to remember past infections for quicker responses in the future.

    Cytotoxic T Lymphocytes (CTL)

    A type of immune cell that directly kills infected cells, especially important in virus control.

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    Natural Killer (NK) Cells

    A type of lymphocyte that attacks body cells infected with viruses instead of the viruses directly.

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    Interferon (IFN)

    Proteins produced by host cells that help prevent viral replication and activate immune cells.

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    Antibody-mediated phagocytosis

    The process where antibodies label pathogens for destruction by phagocytic cells like macrophages.

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    Antibody-dependent cell-mediated cytotoxicity (ADCC)

    A mechanism where immune cells target and kill infected cells by recognizing antibodies bound to the cell.

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    Viral Immunity

    The body's immune response specifically targeting viruses, involving both innate and adaptive components.

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    Oncogenic Virus

    A virus that can lead to cancer development, such as human papillomavirus (HPV).

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    Innate Response to Viruses

    The initial, non-specific immune response to viral infections, including anti-viral effects and cell lysis.

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    Antibody-mediated Neutralization

    The process where antibodies bind to free viruses, preventing them from infecting cells.

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    ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity)

    A mechanism where antibodies mark virus-infected cells for destruction by immune cells like NK cells and macrophages.

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    Viral Immune Evasion

    Strategies used by viruses to escape detection and destruction by the immune system.

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    MHC Class I

    Molecules on cell surfaces that present viral antigens to CTLs for recognition and destruction.

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    Tuberculosis (TB)

    A bacterial infection caused by Mycobacterium tuberculosis, affecting 8.8 million people annually.

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    E. Coli

    A bacterium residing in the gut; most strains are harmless but some can cause food poisoning.

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    Phagocytosis

    The process by which cells ingest harmful bacteria and foreign particles.

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    Innate Response

    The first line of immune defense, including immediate actions like phagocytosis and complement lysis.

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    Adaptive Response

    The immune system's mechanism that adapts to specific pathogens through memory formation.

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    Agglutination

    The clumping of pathogens by antibodies to neutralize them.

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    Complement-mediated lysis

    A process where the complement system destroys bacterial cells by forming pores in their membranes.

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    Mycobacteria

    A type of bacteria, including those causing tuberculosis, often immune to standard responses.

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    Malaria

    A life-threatening disease caused by Plasmodium, transmitted through mosquitoes.

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    IgE

    An antibody that plays a crucial role in allergic reactions and defense against parasites.

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    Candida albicans

    A fungus causing infections like thrush, particularly in immunocompromised individuals.

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    Opsonization

    The process by which pathogens are marked for destruction by antibodies.

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    Study Notes

    Immunity to Infections

    • Innate immunity involves physical and chemical barriers, the interferon (IFN) system, the complement system, phagocytosis/opsonization, and natural killer (NK) cells.

    • Adaptive immunity includes neutralizing antibodies, antibody-mediated phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and cytotoxic T lymphocytes (CTLs).

    • Immune memory provides long-term resistance after infection due to memory cells.

    Infectious Diseases

    • Infectious diseases cause 14.9 million deaths annually globally (2007).

    • Cardiovascular diseases are the leading cause of death at 16.7 million annually globally (2007).

    • Respiratory infections account for 3.96 million annual deaths globally (2007).

    • HIV/AIDS cause approximately 2.77 million deaths annually (2007).

    • Diarrheal diseases are responsible for 1.8 million annual deaths (2007).

    Immunity to Viruses

    • Innate responses to viruses include antiviral effects triggered by interferon (IFN), lysis of infected cells by natural killer (NK) cells, and inflammatory responses.

    • Antibody-mediated immunity against viruses involves neutralization, antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells, macrophages, and neutrophils.

    • Cell-mediated immunity involves cytotoxic T lymphocytes (CTLs).

    • Viruses exhibit immune evasion strategies, such as infecting immune cells, preventing MHC class I presentation, and encoding interferon receptors.

    • Examples of diseases induced by viruses include influenza, HIV (AIDS), and SARS-CoV-2 (COVID-19).

    • Influenza outbreaks have resulted in substantial illness and death globally.

    Immunity to Bacteria

    • Innate immunity mechanisms for bacteria include antimicrobial peptides, complement-mediated lysis, phagocytosis, and opsonization.

    • Adaptive immunity against bacteria involves antibody-mediated mechanisms such as neutralization, agglutination, and phagocytosis.

    Immunity to Parasites

    • Innate immunity against parasites relies on complement-mediated lysis, phagocytosis, and opsonization.

    • Adaptive immunity against parasites involves antibody-mediated mechanisms including agglutination, phagocytosis and antibody-dependent cell-mediated cytotoxicity (ADCC).

    • IgE-mediated responses (mast cells/eosinophils) play a role in parasite immunity.

    • Malaria, caused by Plasmodium, is a prominent mosquito-borne disease causing significant fatalities.

    Immunity to Fungi

    • Innate immune responses to fungi include barriers (skin, normal bacterial flora), phagocytosis (especially by neutrophils), and complement-mediated mechanisms.

    • Adaptive immunity to fungi is not fully understood, but antibodies and possible roles of T lymphocytes are hypothesized.

    • Candidiasis, caused by Candida albicans, is a fungal infection, particularly affecting immunocompromised individuals.

    • Diverse ways to classify fungal diseases exist, such as their site of infection (superficial, cutaneous, subcutaneous, or systemic) and virulence.

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    Immunity to Infections PDF

    Description

    Test your knowledge on immune system responses to viral infections with this quiz. Explore concepts such as antibody-dependent cell-mediated cytotoxicity, the role of interferons, and the mechanisms by which viruses evade immune detection. Ideal for students studying immunology or virology.

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