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Questions and Answers
Which immune cell types are involved in Antibody-dependent cell-mediated cytotoxicity (ADCC)?
Which immune cell types are involved in Antibody-dependent cell-mediated cytotoxicity (ADCC)?
What type of immunity does IFN-α and β belong to?
What type of immunity does IFN-α and β belong to?
Which of the following viruses are known to infect T lymphocytes?
Which of the following viruses are known to infect T lymphocytes?
What is the mechanism of action involved in the neutralization of free viruses by antibodies?
What is the mechanism of action involved in the neutralization of free viruses by antibodies?
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Which of these viruses is known to encode an interferon receptor homolog?
Which of these viruses is known to encode an interferon receptor homolog?
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Which of these viruses is known to block the transport of MHC class I to the cell surface?
Which of these viruses is known to block the transport of MHC class I to the cell surface?
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What is the primary role of cytotoxic T lymphocytes (CTLs) in viral immunity?
What is the primary role of cytotoxic T lymphocytes (CTLs) in viral immunity?
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Through what mechanism can HIV evade the immune system?
Through what mechanism can HIV evade the immune system?
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Which of the following are involved in the innate immune response to viral infection?
Which of the following are involved in the innate immune response to viral infection?
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What type of immunity is responsible for the long-term resistance to infection after exposure to a pathogen?
What type of immunity is responsible for the long-term resistance to infection after exposure to a pathogen?
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Which of the following is NOT an example of a virus that can cause human disease?
Which of the following is NOT an example of a virus that can cause human disease?
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What is the primary function of cytotoxic T lymphocytes (CTL) in the immune response to viral infections?
What is the primary function of cytotoxic T lymphocytes (CTL) in the immune response to viral infections?
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Which type of interferon is primarily involved in the innate immune response to viral infection?
Which type of interferon is primarily involved in the innate immune response to viral infection?
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Which of the following is a key characteristic that distinguishes innate immunity from adaptive immunity?
Which of the following is a key characteristic that distinguishes innate immunity from adaptive immunity?
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Which of these is a consequence of a successful adaptive immune response to a viral infection?
Which of these is a consequence of a successful adaptive immune response to a viral infection?
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What is the main reason why immune-compromised individuals are more susceptible to infections?
What is the main reason why immune-compromised individuals are more susceptible to infections?
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Which of the following statements regarding the 1918 Spanish flu pandemic is CORRECT?
Which of the following statements regarding the 1918 Spanish flu pandemic is CORRECT?
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What is the primary target of the COVID-19 vaccine?
What is the primary target of the COVID-19 vaccine?
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Which of the following is NOT a mechanism used by the innate immune system to combat bacterial infections?
Which of the following is NOT a mechanism used by the innate immune system to combat bacterial infections?
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Which of these bacterial strains is commonly found in the gut and often has beneficial functions for human health?
Which of these bacterial strains is commonly found in the gut and often has beneficial functions for human health?
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What is the primary function of pattern recognition receptors (PRRs) in the innate immune response?
What is the primary function of pattern recognition receptors (PRRs) in the innate immune response?
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Which of the following is NOT a characteristic of a gram-positive bacterium?
Which of the following is NOT a characteristic of a gram-positive bacterium?
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Which of the following is a key mechanism used by the adaptive immune system to control bacterial infections?
Which of the following is a key mechanism used by the adaptive immune system to control bacterial infections?
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What is the primary role of cytotoxic T lymphocytes (CTLs) in the immune response to bacterial infections?
What is the primary role of cytotoxic T lymphocytes (CTLs) in the immune response to bacterial infections?
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Which of the following is a major characteristic of the adaptive immune response compared to the innate immune response?
Which of the following is a major characteristic of the adaptive immune response compared to the innate immune response?
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What is the main reason that individuals with compromised immune systems are more susceptible to fungal infections?
What is the main reason that individuals with compromised immune systems are more susceptible to fungal infections?
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Which of the following is a key feature of the IgE/Mast cell/Eosinophil response in the immune system's fight against parasites?
Which of the following is a key feature of the IgE/Mast cell/Eosinophil response in the immune system's fight against parasites?
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Which of the following is NOT a common way that antibodies contribute to the immune response against parasitic infections?
Which of the following is NOT a common way that antibodies contribute to the immune response against parasitic infections?
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What is the primary reason that there is no effective vaccine for malaria?
What is the primary reason that there is no effective vaccine for malaria?
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Which of the following innate immune mechanisms is NOT directly involved in combating fungal infections?
Which of the following innate immune mechanisms is NOT directly involved in combating fungal infections?
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What is the main reason why individuals with severe neutropenia are more susceptible to fungal infections?
What is the main reason why individuals with severe neutropenia are more susceptible to fungal infections?
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Which of the following is considered a normal flora in the human body but can cause opportunistic infections in immunocompromised individuals?
Which of the following is considered a normal flora in the human body but can cause opportunistic infections in immunocompromised individuals?
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Which of these options is a disease caused by a bacterium found in the gut?
Which of these options is a disease caused by a bacterium found in the gut?
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Which of these is a major factor increasing the risk of fungal infections in individuals with AIDS?
Which of these is a major factor increasing the risk of fungal infections in individuals with AIDS?
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Flashcards
Innate Immunity
Innate Immunity
The body’s first line of defense against infections, including physical barriers and immune responses like phagocytosis.
Adaptive Immunity
Adaptive Immunity
A specific immune response that develops over time, involving antibodies and memory cells for long-lasting immunity.
Immune Memory
Immune Memory
The ability of the immune system to remember past infections for quicker responses in the future.
Cytotoxic T Lymphocytes (CTL)
Cytotoxic T Lymphocytes (CTL)
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Natural Killer (NK) Cells
Natural Killer (NK) Cells
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Interferon (IFN)
Interferon (IFN)
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Antibody-mediated phagocytosis
Antibody-mediated phagocytosis
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Antibody-dependent cell-mediated cytotoxicity (ADCC)
Antibody-dependent cell-mediated cytotoxicity (ADCC)
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Viral Immunity
Viral Immunity
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Oncogenic Virus
Oncogenic Virus
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Innate Response to Viruses
Innate Response to Viruses
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Antibody-mediated Neutralization
Antibody-mediated Neutralization
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ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity)
ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity)
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Viral Immune Evasion
Viral Immune Evasion
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MHC Class I
MHC Class I
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Tuberculosis (TB)
Tuberculosis (TB)
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E. Coli
E. Coli
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Phagocytosis
Phagocytosis
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Innate Response
Innate Response
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Adaptive Response
Adaptive Response
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Agglutination
Agglutination
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Complement-mediated lysis
Complement-mediated lysis
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Mycobacteria
Mycobacteria
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Malaria
Malaria
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IgE
IgE
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Candida albicans
Candida albicans
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Opsonization
Opsonization
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Study Notes
Immunity to Infections
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Innate immunity involves physical and chemical barriers, the interferon (IFN) system, the complement system, phagocytosis/opsonization, and natural killer (NK) cells.
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Adaptive immunity includes neutralizing antibodies, antibody-mediated phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and cytotoxic T lymphocytes (CTLs).
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Immune memory provides long-term resistance after infection due to memory cells.
Infectious Diseases
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Infectious diseases cause 14.9 million deaths annually globally (2007).
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Cardiovascular diseases are the leading cause of death at 16.7 million annually globally (2007).
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Respiratory infections account for 3.96 million annual deaths globally (2007).
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HIV/AIDS cause approximately 2.77 million deaths annually (2007).
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Diarrheal diseases are responsible for 1.8 million annual deaths (2007).
Immunity to Viruses
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Innate responses to viruses include antiviral effects triggered by interferon (IFN), lysis of infected cells by natural killer (NK) cells, and inflammatory responses.
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Antibody-mediated immunity against viruses involves neutralization, antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells, macrophages, and neutrophils.
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Cell-mediated immunity involves cytotoxic T lymphocytes (CTLs).
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Viruses exhibit immune evasion strategies, such as infecting immune cells, preventing MHC class I presentation, and encoding interferon receptors.
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Examples of diseases induced by viruses include influenza, HIV (AIDS), and SARS-CoV-2 (COVID-19).
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Influenza outbreaks have resulted in substantial illness and death globally.
Immunity to Bacteria
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Innate immunity mechanisms for bacteria include antimicrobial peptides, complement-mediated lysis, phagocytosis, and opsonization.
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Adaptive immunity against bacteria involves antibody-mediated mechanisms such as neutralization, agglutination, and phagocytosis.
Immunity to Parasites
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Innate immunity against parasites relies on complement-mediated lysis, phagocytosis, and opsonization.
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Adaptive immunity against parasites involves antibody-mediated mechanisms including agglutination, phagocytosis and antibody-dependent cell-mediated cytotoxicity (ADCC).
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IgE-mediated responses (mast cells/eosinophils) play a role in parasite immunity.
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Malaria, caused by Plasmodium, is a prominent mosquito-borne disease causing significant fatalities.
Immunity to Fungi
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Innate immune responses to fungi include barriers (skin, normal bacterial flora), phagocytosis (especially by neutrophils), and complement-mediated mechanisms.
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Adaptive immunity to fungi is not fully understood, but antibodies and possible roles of T lymphocytes are hypothesized.
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Candidiasis, caused by Candida albicans, is a fungal infection, particularly affecting immunocompromised individuals.
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Diverse ways to classify fungal diseases exist, such as their site of infection (superficial, cutaneous, subcutaneous, or systemic) and virulence.
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Description
Test your knowledge on immune system responses to viral infections with this quiz. Explore concepts such as antibody-dependent cell-mediated cytotoxicity, the role of interferons, and the mechanisms by which viruses evade immune detection. Ideal for students studying immunology or virology.