Veterinary Pathology Quiz

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Questions and Answers

What condition in dogs is associated with locally extensive rugal hyperplasia or hypertrophy?

  • Gastric rupture
  • Chronic surface trauma
  • Multifocal smooth muscle tumors
  • Uremic gastritis (correct)

Which of the following conditions could potentially lead to perforation in the abomasum of bovines?

  • Chronic ruminitis
  • Gastric torsion
  • Uremic mineralization
  • Bovine lymphosarcoma (correct)

What is a possible consequence of NSAID usage in foals?

  • Gastric eversion
  • Ulceration and perforation (correct)
  • Candidiasis in the stomach
  • Leiomyoma formation

Which condition is likely to cause acute gastric rupture in horses?

<p>Volvulus of the lower intestine (D)</p> Signup and view all the answers

Which condition is associated with Candidiasis in piglets?

<p>Tongue and esophagus trauma (C)</p> Signup and view all the answers

What effect does perfringens enterotoxin (CPE) have on the plasma membrane?

<p>It alters the plasma membrane. (A)</p> Signup and view all the answers

Which type of enterotoxemia is associated with 'struck' in mature sheep?

<p>Type C enterotoxemia (B)</p> Signup and view all the answers

What is the typical gross finding in acute hemorrhagic necrotizing enteritis?

<p>Mucosal ulceration surrounded by hyperemia (D)</p> Signup and view all the answers

What condition is associated with Clostridium perfringens type D?

<p>Overeating disease (D)</p> Signup and view all the answers

What microscopic finding is typically present in acute necrohemorrhagic enteritis?

<p>Large numbers of bacilli limited to necrotic tissue (B)</p> Signup and view all the answers

Which lung condition is associated with the presence of Fuso bacterium?

<p>Necrotic Laryngitis (A)</p> Signup and view all the answers

What is commonly associated with the conditions labeled ovine progressive pneumonia?

<p>Diffuse Interstitial Pneumonia (A)</p> Signup and view all the answers

Which condition is characterized as chronic and often involves the nasal cavity in bovines?

<p>Chronic Purulent Sinusitis (B)</p> Signup and view all the answers

What type of pneumonia is linked to the pathogen known as Pasteurella?

<p>Fibrinous Pleuritis Pneumonia (C)</p> Signup and view all the answers

In bovines, which lung condition is characterized by the formation of multiple abscesses?

<p>Multiple Abscessation (D)</p> Signup and view all the answers

What is the principal cause of centrilobular necrosis in the liver?

<p>Acetaminophen toxicity (A)</p> Signup and view all the answers

Which condition leads to the most significant necrosis in cases of anemia in the liver?

<p>Centrilobular necrosis (B)</p> Signup and view all the answers

What plant is known to cause mid-zonal necrosis in the liver?

<p>Cocklebur plant (A)</p> Signup and view all the answers

What condition is characterized by the combination of nodular regeneration and fibrosis in the liver?

<p>Cirrhosis (D)</p> Signup and view all the answers

In liver pathology, what is the potential outcome if regeneration is unsuccessful after injury?

<p>Fibrosis (A)</p> Signup and view all the answers

What describes the tissue appearance of a liver affected by extensive fibrosis?

<p>Lobated like a kidney (C)</p> Signup and view all the answers

Which mechanism is responsible for the tipping balance towards progressive fibrosis?

<p>Continued liver insult or severe initial damage (B)</p> Signup and view all the answers

What is the major characteristic of acute centrilobular necrosis?

<p>Principal lesion of a specific disorder (A)</p> Signup and view all the answers

What are the three essential features required to diagnose cirrhosis?

<p>Necrosis of hepatocytes, hyperplasia of nodules, and fibrosis (A)</p> Signup and view all the answers

Which disease is characterized by intranuclear inclusion bodies in hepatocytes?

<p>Infectious Canine Hepatitis (B)</p> Signup and view all the answers

What is a common post-mortem finding in dogs suffering from Infectious Canine Hepatitis?

<p>Hepatic necrosis and hemorrhage (A)</p> Signup and view all the answers

What can Rift Valley Fever cause in ruminants?

<p>Abortion and neonatal death (A)</p> Signup and view all the answers

Which of the following is a classical lesion associated with Campylobacter-induced hepatitis?

<p>Circumscribed round target-like foci (D)</p> Signup and view all the answers

Which parasites are commonly associated with parasitic hepatitis in ruminants?

<p>Fasciola hepatica and Fascioloides magna (A)</p> Signup and view all the answers

The appearance of a liver affected by Rift Valley Fever is typically described as:

<p>Pale, swollen, and containing foci of hemorrhage (A)</p> Signup and view all the answers

Which statement accurately reflects how Fasciola hepatica affects cattle?

<p>Leads to necrosis and secondary fibrosis of the biliary tree (A)</p> Signup and view all the answers

What congenital anomaly is characterized by the absence of jaws?

<p>Agnathia (A)</p> Signup and view all the answers

Which bacteria is primarily associated with enterotoxemia in neonatal animals?

<p>Clostridium perfringens type A (D)</p> Signup and view all the answers

What results from the invasion of Salmonella into macrophages?

<p>Bacteremia spreading the infection to other organs (A)</p> Signup and view all the answers

Which type of oral neoplasia is most commonly associated with dogs?

<p>Melanoma (C)</p> Signup and view all the answers

Which of the following is NOT a symptom of salmonellosis?

<p>Decreased appetite (C)</p> Signup and view all the answers

What is a significant consequence of malabsorption caused by Salmonella infection?

<p>Dehydration due to electrolyte imbalance (A)</p> Signup and view all the answers

Cleft palate is primarily caused by which of the following?

<p>Teratogenic toxins (D)</p> Signup and view all the answers

Which condition is the correct term for a shortened jaw?

<p>Brachygnathia (D)</p> Signup and view all the answers

What is a key characteristic of Salmonella identified under a light microscope?

<p>Necrotizing hepatopathy (A)</p> Signup and view all the answers

Which animal is predominantly affected by Malignant Catarrhal Fever?

<p>Sheep (B)</p> Signup and view all the answers

Flashcards

Clostridial enterotoxemia

A type of Clostridium perfringens infection in sheep and goats that causes severe inflammation in the intestines, leading to bloody diarrhea and potential death.

Epsilon toxin

A toxin produced by Clostridium perfringens type D, responsible for the deadly intestinal inflammation seen in Clostridial enterotoxemia.

Jejunum and ileum

The primary site of damage in Clostridial enterotoxemia, characterized by acute inflammation, necrosis, and bleeding.

Acute necrohemorrhagic enteritis

A characteristic finding of Clostridial enterotoxemia, where the intestinal lining shows signs of intense inflammation and cell death.

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Hemorrhagic enterotoxemia

A manifestation of Clostridial enterotoxemia type C in calves, lambs, and piglets.

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Centrilobular Necrosis

Necrosis occurring around the central vein of a liver lobule, often caused by acetaminophen toxicity or chronic passive congestion.

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Midzonal Necrosis

A type of hepatic necrosis affecting hepatocytes located halfway between the central vein and the portal area. It can be caused by certain plants like Cocklebur.

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Liver Fibrosis

Excess fibrous connective tissue replaces damaged liver cells, leading to scarring and potential loss of liver function.

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Cirrhosis

The 'end stage' of liver disease, characterized by nodular regeneration of liver tissue combined with extensive fibrosis. This makes it very difficult for the liver to function properly.

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Abomasal Ostertagiosis

A condition in ruminants, specifically cattle, where the abomasum, the fourth stomach compartment, is affected by a parasitic infestation. This infestation is caused by the parasite Ostertagia ostertagi.

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Clostridial Abomasitis

This condition is characterized by an inflammation of the abomasum in cattle, caused by Clostridium perfringens bacteria. This bacterium produces toxins that damage the lining of the abomasum, leading to inflammation and potential complications.

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Mycotic Ulcerative Abomasitis

A condition where the lining of the abomasum in cattle is ulcerated and inflamed. This inflammation is caused by fungal organisms (mycotic).

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Abdomen Mesothelioma

This is a condition characterized by an excessive accumulation of fluid in the abdominal cavity (abdomen) of cattle. This fluid build-up is often caused by the growth of malignant cells in the mesothelial lining of the abdominal cavity.

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Rumen Lactic Acidosis (Grain Overload)

This condition refers to a severe metabolic disorder seen in cattle, particularly dairy cows, that is caused by an excessive intake of readily fermentable carbohydrates, such as grains. The rapid fermentation of these carbohydrates in the rumen produces excessive lactic acid, which can cause a dramatic drop in the rumen's pH, leading to various complications.

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Interstitial Pneumonia (Ovine)

A type of lung disease causing inflammation and thickening of the lung tissue. It is commonly caused by bacteria like Pasteurella and in sheep, by a slow virus causing Ovine Progressive Pneumonia (OPP).

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Ovine Progressive Pneumonia (OPP)

A disease primarily affecting sheep, characterized by a gradual thickening and fibrosis of lung tissue. It's caused by a lentivirus (similar to HIV) and leads to respiratory problems.

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Bronchopneumonia (Bovine)

A type of lung inflammation caused by the bacterium Pasteurella. It usually involves more severe inflammation in the air sacs and bronchioles (small airways).

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Haemophilus somnus Pneumonia (Bovine)

An infection of the lung in cattle caused by the bacterium Haemophilus somnus. It often results in pneumonia and can spread to various organs.

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Verminous Bronchitis (Bovine)

A type of lung infection caused by a roundworm parasite called Dictyocaulus viviparous. The worms live in the bronchioles of the lungs, causing coughing, labored breathing, and sometimes pneumonia.

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Infectious Canine Hepatitis

A disease that primarily affects puppies and is caused by a virus. It is characterized by necrosis (cell death) and hemorrhage (bleeding) in the liver, leading to inflammation.

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Rift Valley Fever

An infectious disease affecting both humans and animals, primarily ruminants. It is characterized by extensive necrosis (cell death) and hemorrhage (bleeding) in the liver, often leading to abortion and death in affected animals.

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Campylobacter Hepatis

A bacterial infection that can cause abortion in sheep. The bacteria cause necrosis (cell death) in the liver, resulting in characteristic circular lesions.

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Tuberculosis Hepatitis

A type of infection that involves the formation of granulomas (clumps of immune cells) in the liver. These granulomas contain multinucleated giant cells, which are cells with multiple nuclei.

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Parasitic Hepatitis

A condition that can be caused by flukes, particularly Fasciola hepatica and Fascioloides magna. It affects ruminants and can cause necrosis (cell death) and fibrosis (scarring) of the liver.

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Fascioloides magna Hepatitis

A parasitic infection caused by the fluke Fascioloides magna. This fluke is not a normal parasite in cattle and therefore causes more severe lesions compared to other animals.

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Fasciola hepatica Hepatitis

A form of parasitic hepatitis caused by the fluke Fasciola hepatica. This fluke infects the liver, causing necrosis (cell death) and fibrosis (scarring) of the biliary tree.

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Cleft Palate

Cleft palate is a congenital anomaly of the mouth, where the roof of the mouth (palate) doesn't close completely during fetal development, leaving an opening.

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Brachygnathia Inferior

A short lower jaw (mandible) is referred to as Brachygnathia inferior. It's one of the many jaw abnormalities that can develop in animals.

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Prognathia Inferior

Prognathia Inferior refers to an excessively elongated lower jaw (mandible), another type of congenital jaw abnormality in animals.

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Stomatitides

Stomatitides encompass inflammation of various mouth structures, including lips, pharynx, tongue, gums, tonsils, and palate. They can be caused by various factors, ranging from infections to trauma.

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Foot-and-Mouth Disease (FMD)

Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals like cattle, pigs, sheep, and goats. It causes widespread blisters on the mouth and feet, leading to significant economic losses.

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Malignant Catarrhal Fever (MCF)

Malignant Catarrhal Fever (MCF) is a serious, often fatal, viral disease that primarily affects cattle, sheep, and goats. The virus attacks the respiratory and digestive systems, causing severe inflammation and internal bleeding.

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Salmonella

Salmonella is a genus of rod-shaped, gram-negative bacteria that commonly cause food poisoning in humans and animals. It can lead to severe illness, including diarrhea, abdominal pain, fever, and even death.

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Wooden Tongue

Wooden Tongue is a bacterial disease caused by Actinomyces bovis, affecting cattle primarily. It causes a chronic inflammation of the tongue, leading to swelling and difficulty in feeding.

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Lumpy Jaw

Lumpy Jaw is a chronic, granulomatous infection caused by Actinomyces bovis primarily affecting cattle. It results in a hard, lumpy swelling of the jawbones, sometimes leading to difficulty in chewing.

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Enterotoxemia

Enterotoxemia, caused by Clostridium perfringens type A, is a condition where toxins produced by bacteria in the gut cause severe damage to the lining of the intestines, leading to diarrhea, dehydration, and even death.

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Study Notes

Alimentary System Pathology

  • Overview: This presentation covers selected cases of alimentary system diseases in animals.

Case 1

  • Signalment: Male, 6-month-old Irish Setter dog.
  • History: Presented with chronic regurgitation of solid meals, progressive emaciation, dyspnea, and coughing.
  • Diagnosis: Persistent right 4th aortic arch and megaesophagus.
  • Respiratory Signs: Aspiration of food during regurgitation (aspiration pneumonia).

Case 2

  • History: Rumen from a steer that died after being sick for two days. The animal exhibited drowsiness and was treated with antibiotics. The diet consisted of pasture, hay, french fries, and grains
  • Diagnosis: Multifocal hemorrhagic infarcts.
  • Condition: Mycotic rumenitis

Case 3

  • Signalment: Male, 5-year-old Great Dane.
  • History: Dog presented with severe acute abdominal pain and vomiting; the animal died despite treatment. Abdomen markedly distended at necropsy.
  • Abnormalities: Stomach markedly dilated (filled with fluid and gas), serosa congested, spleen engorged, displaced to the right, and V-shaped.
  • Diagnosis: Gastric dilation and volvulus.

Case 4

  • Signalment: 3-month-old female Mastiff.
  • History: Presented with severe abdominal pain and vomiting; died despite treatment. Abdomen markedly distended at necropsy.
  • Possible Causes: Any intestinal obstruction (foreign bodies, displacements, stenosis, atresia, paralytic ileus).
  • Diagnosis: Small intestine: Intussusception

Case 5

  • Signalment: 18-month-old female bovine.
  • History: Presented due to poor body condition and diarrhea.
  • Morphologic Diagnosis: Severe, multifocal ulcerative stomatitis and esophagitis

Ileum Changes

  • Findings: Peyer's patches and overlying epithelium are necrotic and covered by blood.
  • Differential Diagnoses: BVD, MCF, Rinderpest.

Case 7

  • History: Lamb euthanized due to severe neurological signs; animal was in excellent nutritional condition.
  • Differential Diagnoses: Enterotoxemia and intestinal volvulus.

Case 2 (Weimaraner)

  • Signalment: Female, 13-year-old Weimaraner.
  • History: Presented for anorexia, depression, vomiting, melena, and emaciation.
  • Lab Results: Increased BUN and creatinine, regenerative anemia.
  • Morphologic Diagnosis: Focal, ulcerative stomatitis (oral ulcer).

Additional Topics:

  • Other Stomatitides: Issues concerning lips, pharynx, tongue, gums, tonsils, and palate.
  • Cheilitis: Can be due to ORF (contagious ecthyma).
  • PPR: Infectious disease in ruminants.
  • Foot-and-Mouth Disease (FMD): Disease affecting cloven-hoofed animals. Causes lesions in the mouth.
  • Malignant Catarrhal Fever (MCF): Characterized by skin and mucous membrane lesions.
  • Johne's Disease: Infectious disease in ruminants.
  • Bovine Viral Diarrhea (BVD): Disease characterized by various signs and tissue changes.
  • Salmonella: Bacterial infection with several clinical syndromes. Affects multiple tissues and organs.
  • Wooden Tongue: Veterinary condition affecting the tongue.
  • Lumpy Jaw: Bacterial infection of jaw in ruminants.
  • Oral Papillomas: Benign tumors of the oral cavity.
  • Oral Neoplasia: Malignant oral tumors in dogs and cats. Include squamous cell carcinoma (SCC), melanoma, fibrosarcoma, and osteosarcoma
  • Causes of Cleft Palate: Can be hereditary or due to teratogenic toxins (drugs, environmental toxins)
  • Congenital Jaw Anomalies: Agnathia (absence), brachygnathia( shortened), and prognathia (elongated)
  • Brachygnathia Inferior: Characterized by a shortened lower jaw.
  • Prognathia Inferior: Characterized by a prolonged lower jaw.
  • Hepatic Lipidosis: Abnormal accumulation of triglycerides in hepatocytes.
  • Congestive Hepatopathy: (Nutmeg Liver) Liver dysfunction due to venous congestion, commonly linked to heart failure.
  • Liver Necrosis: Death of liver cells due to various causes; can be periportal or centrilobular.
  • Fibrosis: A general response of the liver to injury. Scar tissue formation.
  • Cirrhosis: End-stage liver damage; characterized by scarring and nodular regeneration. Indicates irreversible damage.
  • Hepatitis: Inflammation of the liver. Viral and bacterial causes.
  • Rift Valley Fever: Viral disease causing abortion and neonatal death in ruminants, often with liver necrosis.
  • Bacterial Hepatitis: Liver inflammation caused by bacteria (e.g., Campylobacter fetus, Campylobacter jejuni).
  • ...Multiple additional conditions and diagnoses associated with various gross and microscopic presentations of organ pathology, along with etiology are present in this presentation.

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