Veterinary Pathology Quiz: Bovine Diseases

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Questions and Answers

What is another name for Bovine Lymphangitis?

  • Ulcerative lymphadenitis
  • Edematous skin disease (correct)
  • Pus-producing disease
  • Nodular skin disease

Corynebacterium pseudotuberculosis is a Gram-negative organism.

False (B)

What are common symptoms of Bovine Lymphangitis?

Edema of legs and brisket, nodules and abscess on skin, ulcerations of skin, enlarged lymph nodes.

The organism responsible for Bovine Lymphangitis can survive in ______ and resist phagocytosis.

<p>macrophages</p> Signup and view all the answers

Match the following biovars of Corynebacterium pseudotuberculosis with their characteristics:

<p>Biovar equi = Reduces nitrates, ulcerative lymphangitis Biovar ovis = Does not reduce nitrates, caseous lymphadenitis</p> Signup and view all the answers

What is the consequence of a corneal ulcer if it results in perforation?

<p>Blindness may result (D)</p> Signup and view all the answers

Neovascularization of the cornea occurs from the sclera during the healing process.

<p>True (A)</p> Signup and view all the answers

What bacterium is isolated for diagnosis from lachrymal or nasal swabs in corneal cases?

<p>Moraxella bovis</p> Signup and view all the answers

Once a corneal ulcer heals, the blood vessels ____, and the eye may appear clear again.

<p>recede</p> Signup and view all the answers

Match the condition with its description:

<p>Photophobia = Sensitivity to light Lachrymal discharge = Excessive tearing Corneal opacity = Grey appearance of the cornea Conjunctivitis = Inflammation of the conjunctiva</p> Signup and view all the answers

What is NOT a common clinical sign of Blackleg in cattle?

<p>Continuous coughing (C)</p> Signup and view all the answers

The swelling associated with Blackleg is initially cold and painless.

<p>False (B)</p> Signup and view all the answers

What body parts are usually affected in cases of Blackleg?

<p>Heavy skeletal muscle regions, upper part of one limb, and can include diaphragm and heart muscle.</p> Signup and view all the answers

Blackleg in cattle leads to _________ from the nostrils and anus.

<p>blood-stained froth exudates</p> Signup and view all the answers

Match the following clinical signs with their correct descriptions:

<p>Sudden death = Occurs without prior symptoms Bloating = Happens quickly after death Edema = Swelling with crepitation upon palpation Dark tissue = Revealed during incision of affected muscle</p> Signup and view all the answers

What is the primary cause of pinkeye in cattle?

<p>Bacterial infection (B)</p> Signup and view all the answers

Older cattle have higher colostral immunity compared to younger cattle.

<p>False (B)</p> Signup and view all the answers

What is the incubation period for infectious bovine keratoconjunctivitis (IBK)?

<p>2-7 days</p> Signup and view all the answers

The primary mechanical vector for pinkeye is __________.

<p>flies</p> Signup and view all the answers

Match the stages of IBK with their characteristics:

<p>Stage 1 = Blepharospasm (excessive blinking) Stage 2 = Ulcer continues to develop Stage 3 = Corneal ulceration visible Stage 4 = Severe symptoms and possible resolution</p> Signup and view all the answers

Which of the following describes immune response in older cattle?

<p>They have protective antibodies on the eye surface. (B)</p> Signup and view all the answers

Infectious bovine keratoconjunctivitis can resolve at any stage without treatment.

<p>True (A)</p> Signup and view all the answers

What types of contact can spread the infectious agent of pinkeye?

<p>Direct and indirect contact with nasal and ocular secretions</p> Signup and view all the answers

What is a common clinical sign of the illness described?

<p>Profound toxemia (A)</p> Signup and view all the answers

A local lesion at the site of infection is characterized by a hard and dry swelling.

<p>False (B)</p> Signup and view all the answers

What timeframe do affected animals typically die after the first appearance of signs?

<p>24 to 48 hours</p> Signup and view all the answers

The presence of _______ may or may not be observed depending on the type of infection.

<p>emphysema</p> Signup and view all the answers

Match the clinical signs with their descriptions:

<p>Fever and Depression = General signs indicating illness Congested mucous membranes = Indicates poor circulation or hypoxia Severe pain on palpation = Response to infection at the site Extensive frothy exudation = Fluid discharge from a wound</p> Signup and view all the answers

What is the primary cause of lesions in ringworm?

<p>Fungi (C)</p> Signup and view all the answers

Ringworm is a disease that requires treatment to resolve.

<p>False (B)</p> Signup and view all the answers

What are the typical characteristics of ringworm lesions?

<p>Circular areas of alopecia with a whitish grey scale accumulation.</p> Signup and view all the answers

In ringworm, dermatophytes produce an __________ color upon fluorescence.

<p>apple-green</p> Signup and view all the answers

Match the following diagnostic methods with their descriptions:

<p>Clinical signs = Visual confirmation of lesions and symptoms Wood's lamp = Fluorescence test to detect fungi Skin scraping = Microscopic examination of lesion samples Culture on sabouraud dextrose agar = Laboratory growth of suspected fungal pathogens</p> Signup and view all the answers

Where are ringworm lesions commonly found in calves?

<p>On the head, neck, and trunk (A)</p> Signup and view all the answers

Wood's lamp can produce false negatives during diagnosis.

<p>True (A)</p> Signup and view all the answers

What is the approximate diameter of lesions caused by ringworm?

<p>About three centimeters.</p> Signup and view all the answers

Flashcards

Bovine Lymphangitis

An infectious disease that primarily affects buffaloes, causing edema (swelling) of the legs and brisket, skin nodules and abscesses, skin ulcerations, and enlarged lymph nodes.

Corynebacterium pseudotuberculosis

The causative agent of bovine lymphangitis. It is a gram-positive, intracellular bacterium that produces necrotizing exotoxins.

Intracellular Survival of Corynebacterium pseudotuberculosis

The ability of Corynebacterium pseudotuberculosis to survive and multiply inside macrophages, evading the immune system's phagocytosis.

Nitrate Reduction Capability

The ability of some bacteria to break down nitrates into nitrites. This trait is used to differentiate between 'Biovar equi' and 'Biovar ovis' strains of Corynebacterium pseudotuberculosis.

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What is photophobia?

A common symptom of Moraxella bovis infection in cattle, where the eye becomes excessively sensitive to light.

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What is corneal opacity?

A cloudiness or opacity that develops on the cornea, a transparent layer covering the eye, due to infection or damage.

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What is conjunctivitis?

A type of eye infection characterized by inflammation of the conjunctiva, the transparent membrane covering the white part of the eye.

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What is neovascularization of the cornea?

The formation of new blood vessels in the cornea, usually as a response to inflammation or damage.

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What is a corneal scar?

When an ulcer on the cornea heals, leaving behind a scar that may slightly impair vision.

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Blackleg: Sudden Death

Sudden death in cattle without prior symptoms, often with the affected hind leg stiffly extended, bloating, and blood-stained froth from nostrils.

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Blackleg: Muscle Swelling

Swelling in the skeletal muscles, initially hot and painful, later becoming cold and painless with a crackling sound upon palpation.

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Blackleg: Muscle Tissue

Presence of dark, swollen tissue with a foul odor upon cutting into the affected muscle.

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Blackleg: Common Locations

Lesions typically confined to the upper part of one limb but can occasionally affect other areas like the tongue, heart muscle, diaphragm, psoas muscles, and brisket.

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Blackleg: Diagnosis

Examination of all skeletal muscles is essential to ensure the presence of Blackleg lesions.

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What is Corynebacterium pseudotuberculosis?

The bacteria responsible for causing bovine lymphangitis, a potentially fatal disease affecting cattle.

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What is bovine lymphangitis?

This disease affects cattle primarily, causing swelling in the legs and brisket, skin nodules and abscesses, skin ulcerations, and enlarged lymph nodes.

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What is intracellular survival of Corynebacterium pseudotuberculosis?

The ability of Corynebacterium pseudotuberculosis to survive and multiply within macrophages, making it harder for the immune system to eliminate it.

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What is toxemia in bovine lymphangitis?

The process by which toxins produced by Corynebacterium pseudotuberculosis spread throughout the body, causing systemic effects.

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How is bovine lymphangitis transmitted?

The spread of Corynebacterium pseudotuberculosis typically occurs through contaminated wounds. Spores in the soil can enter wounds, causing the infection.

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What is Infectious Bovine Keratoconjunctivitis (IBK)?

Infectious Bovine Keratoconjunctivitis (IBK) is an eye infection in cattle, most commonly found in younger cattle. It's spread through direct or indirect contact with nasal and ocular secretions from infected animals, primarily through flies.

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Why are younger cattle most affected by IBK?

Cattle develop immunity to IBK over time, but younger cattle are more susceptible due to their weaker immune systems. Older cattle have built up a layer of protection through previous exposure.

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How are flies involved in IBK?

Flies play a key role in spreading the bacteria that causes IBK. They act as mechanical vectors, carrying the bacteria from infected cattle to healthy ones. This is why flies are a major factor in IBK outbreaks.

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What are the different stages of IBK?

IBK has distinct stages. It can be classified as Stage 1, Stage 2, Stage 3, or Stage 4, each characterized by a progression of symptoms.

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Describe Stage 1 of IBK.

In Stage 1, a cow might show excessive blinking (blepharospasm) or squinting. This initial stage can occur within 24-48 hours.

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What happens in Stage 2 of IBK?

Stage 2 progresses to a development of a corneal ulcer. The ulcer is a wound on the eye's surface and it starts to form within 24-48 hours after Stage 1.

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Describe Stage 3 of IBK.

The corneal ulcer continues to grow and deepen in Stage 3. Some cows may recover here with treatment, but if left untreated, they will likely progress to Stage 4.

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What happens in Stage 4 of IBK?

Stage 4 is the most severe stage of IBK, characterized by a large corneal ulcer with pus-filled discharge. Without treatment, blindness and other complications may occur.

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Ringworm in Calves

A fungal infection common in calves, usually affecting the head, neck, and trunk, characterized by circular lesions with hair loss and a whitish-grey, scaly buildup.

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Coalescence of Ringworm Lesions

The tendency of ringworm lesions to grow and merge together, forming larger, irregular patches on the animal's skin.

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Self-Limiting Nature of Ringworm

The ability of the infected animal's immune system to fight off the ringworm fungus, leading to a natural recovery from the infection within 2 to 6 months.

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Wood's Lamp Examination

A diagnostic tool used to identify ringworm by exposing the affected area to a UV light that causes the fungus to glow a characteristic apple-green color.

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Skin Scraping for Ringworm Diagnosis

A type of diagnostic test involving collecting skin scrapings from the edge of the ringworm lesion and examining them under a microscope to identify the fungal spores.

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Culturing Ringworm Spores

A common diagnostic method for ringworm that involves cultivating the fungal spores collected from skin scrapings on a special growth medium called Sabouraud dextrose agar.

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Local Application for Ringworm

A common treatment for ringworm where the crusty scales are removed from the lesion before applying a medicated solution or ointment.

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Widespread Ringworm Infection

A widely spread ringworm infection in a group of animals requiring a different treatment approach compared to a localized infection in a few individuals.

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Study Notes

Infectious Bovine Lymphangitis

  • Another name: Edematous skin disease
  • Problems: Edema of legs and brisket, nodules and abscesses on skin, ulcerations of skin, enlarged lymph nodes
  • More common in: Buffaloes
  • Etiology: Corynebacterium pseudotuberculosis, gram-positive organism, intracellular bacteria, produces necrotizing exotoxins (phospholipase), survives in macrophages and resists phagocytosis
  • Susceptibility: Buffaloes are more susceptible, have scant hair, and are often exposed to cool water/mud. Cattle are also susceptible.
  • Source: Discharging pus from infected animals, insects
  • Mode of Transmission (MOT): Thorough wound infection and insect transmission
  • Common during: Summer months
  • Pathogenesis: Enters body via skin, invades lymphatic vessels. Increases vascular permeability, form abscesses and edema.

Clinical Signs

  • Fever: Returns to normal after a few days
  • Loss of Appetite: Mild
  • Milk Production: Mild reduction
  • Skin Swellings: Firm, warm, painful, and later soften and may contain blood-tinged fluid. Puncturing the swellings won't always immediately reveal fluid. Ulcerations of the skin may be hemorrhagic. Swellings are commonly found on the brisket and lower limbs.
  • Inflammatory Edema: Affects brisket and limbs (especially forelimbs). Lymph nodes, especially prescapular nodes, enlarge.
  • Ulcerations: Possible hemorrhagic skin ulcerations.
  • Pyogranulomatous Lesions: Occur on the skin, especially lower limbs.
  • Visceral Forms: Mastitis, pneumonia, and pyelonephritis can occur.

Laboratory Diagnosis

  • Sample: Pus or fluid from unopened swellings, lymph node biopsies, ulcerated skin, or granulomas
  • Direct Smear: Gram-positive coccobacilli
  • Culture: On blood agar
  • Laboratory Animal: Intraperitoneal injections of pus into guinea pigs may produce purulent orchitis.

Treatment

  • Antibiotics: Penicillin, penicillin-streptomycin, amoxicillin, or long-acting oxytetracycline for 1-2 months
  • Anti-inflammatory: Dexamethasone (not for pregnant animals), flunixin.
  • Diuretic: Sodium potassium citrate, Lasix (in glucose 25% solution). Diurizone for 2-3 days.
  • Surgical Interference: With abscesses and wounds

Control

  • Insect Control
  • Hygiene
  • Disposal of Pus: Hygienic disposal of pus from infected animals
  • Autogenous Vaccine: Vaccine made from organisms infecting the animal
  • BCG Vaccine: Should not be used as it can produce a false positive reaction to tuberculin testing

Infectious Bovine Keratoconjunctivitis (IBK) - Pinkeye

  • Causative Agent: Moraxella bovis (gram-negative coccobacilli)
  • Environmental Factors: Ultraviolet light, plant pollens, flies, tall grasses, and dust
  • Source: Ocular and nasal discharges.
  • MOT: Mechanical vector, direct or indirect contact with secretions of infected animals. Common in summer.

Clinical signs, IBK

  • Incubation Period: 2-7 days
  • Four Stages (no treatment): Stages progress through various stages of severity: blepharospasm, photophobia, conjunctivitis, lachrymal discharge, corneal opacity. Ulcers will progress, then will resolve.
  • Corneal Scar: Will remain.
  • Clinical Signs: inflammation, redness, crusts or pus in the eye, possible blindness.
  • Diagnosis: Clinical signs, history, laboratory isolation of Moraxella bovis.

Ringworm

  • Other Names: Dermatophytosis, Trichophytosis, Microsporosis, Dermatomycosis
  • Definition: Superficial fungal disease
  • Etiology: Caused by Trichophyton, Trichophyton equinum, Microsporum, and Microsporum gypseum
  • Susceptibility: Affecting all animals and humans. Calves are more susceptible
  • Source: Crusts on infected animals, spores in soil, bedding, and grooming equipment.
  • MOT: Contact; spores and fungal material can also contaminate other surfaces and thus spread the disease indirectly

Clinical Signs (Ringworm)

  • Lesions: Circular, with alopecia and crusts; typically on the head, neck, and trunk of calves. Vary in size up to about 3cm.
  • Diagnosis: Clinical signs, skin scraping (identify fungi on the hair and external surface).
  • Laboratory Diagnosis: Skin scraping (identifying fungal spores); Culture on Sabouraud dextrose agar.

Treatment (Ringworm)

  • Local Application: Scraping lesions, scraping the surface to remove scabs. Application of treatment (ointments, sprays, topical solutions).

Mange

  • Etiology: Mites (e.g., Psoroptes, Chorioptes, Sarcoptes, Demodex)
  • Signs: Intense itching, or pruritus, hair loss, and lesions that may become thick and scabbed over or crusted.
  • Treatment: Topical treatments such as sulfur ointments, acaricides, diazinon, malathion, lime sulfur, or macrocyclic lactones

Gas Gangrene

  • Definition: Acute wound infection due to Clostridium organisms.
  • Etiology: C. novyi, C. sordellii, C. septicum, C. chauvoei, C. perfringens
  • Signs: Severe, rapid, progressive inflammation; tissue necrosis that can be localized or spread throughout the body; gas and pus formation in tissues.
  • Treatment: Rapid treatment with penicillin, anti-inflammatory medications, and supportive care.

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