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Questions and Answers
What is indicated by an increased Mean Cell Volume (MCV)?
What is indicated by an increased Mean Cell Volume (MCV)?
Which type of anemia is characterized by larger than normal red blood cells due to impaired red blood cell production?
Which type of anemia is characterized by larger than normal red blood cells due to impaired red blood cell production?
What does a normal MCV indicate about red blood cells?
What does a normal MCV indicate about red blood cells?
What does a high MCHC measurement indicate?
What does a high MCHC measurement indicate?
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What is the primary role of reticulocytes in the context of increased MCV?
What is the primary role of reticulocytes in the context of increased MCV?
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Which factor can affect the normal ranges of MCV in veterinary medicine?
Which factor can affect the normal ranges of MCV in veterinary medicine?
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Which condition is associated with elevated MCHC?
Which condition is associated with elevated MCHC?
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What does an increased RDW indicate?
What does an increased RDW indicate?
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What does the Mean Corpuscular Hemoglobin Concentration (MCHC) signify?
What does the Mean Corpuscular Hemoglobin Concentration (MCHC) signify?
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What type of anemia is characterized by low MCV?
What type of anemia is characterized by low MCV?
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How is RDW calculated?
How is RDW calculated?
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What is the significance of anisocytosis?
What is the significance of anisocytosis?
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What blood condition is suggested by an increase in reticulocyte count?
What blood condition is suggested by an increase in reticulocyte count?
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Which type of anemia can lead to increased RDW?
Which type of anemia can lead to increased RDW?
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What leads to the development of hyperchromic anemia?
What leads to the development of hyperchromic anemia?
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Which of the following increases when both large and small red blood cells are present?
Which of the following increases when both large and small red blood cells are present?
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Which condition is least likely to be associated with increased MCV?
Which condition is least likely to be associated with increased MCV?
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What is a likely cause of decreased MCV?
What is a likely cause of decreased MCV?
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Which condition is correctly associated with typical MCHC measurement?
Which condition is correctly associated with typical MCHC measurement?
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Which factor contributes most significantly to higher MCV in macrocytic anemia?
Which factor contributes most significantly to higher MCV in macrocytic anemia?
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What is the primary outcome of iron deficiency anemia on red blood cell size?
What is the primary outcome of iron deficiency anemia on red blood cell size?
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Which breed is known for familial microcytosis without anemia?
Which breed is known for familial microcytosis without anemia?
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What does a low MCHC measurement indicate?
What does a low MCHC measurement indicate?
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Which of the following conditions is a common cause of decreased MCV?
Which of the following conditions is a common cause of decreased MCV?
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Study Notes
Mean Cell Volume (MCV)
- MCV measures the average size of red blood cells, indicating types of anemia.
- Normal MCV ranges:
- Canine: 64-72 fL
- Feline: 40-52 fL
- Equine: 43-55 fL
- Bovine: 38-51 fL
- Caprine: 16-22 fL
Increased MCV Causes
- Myeloproliferative Disease: Rare disorder leading to abnormal blood cell proliferation in bone marrow.
- Vitamin B12/Folate Deficiency: Causes macrocytic anemia due to impaired DNA synthesis; relatively uncommon.
- Familial Macrocytosis: Seen in poodles, resulting in larger-than-normal red blood cells.
- Regenerative Anemia: Most common cause, where bone marrow increases reticulocyte production in response to anemia.
- FeLV-related Non-regenerative Macrocytic Anemia: Associated with feline leukemia virus, causing larger red blood cells without increased reticulocytes.
Decreased MCV Causes
- Iron Deficiency Anemia: Most frequent cause due to chronic blood loss; results in microcytic anemia as nuclear generation is delayed.
- Congenital Portosystemic Shunts: Abnormal blood vessel redirects blood from the liver, impairing iron utilization and causing microcytic anemia.
- Familial Microcytosis in Akitas: Genetic trait leading to smaller red blood cells without anemia.
Mean Corpuscular Hemoglobin Concentration (MCHC)
- MCHC indicates the average hemoglobin concentration in packed red cells; low levels are termed hypochromia.
- Decreased MCHC is associated with:
- Regenerative Anemias: Immature red cells contain less hemoglobin.
- Iron Deficiency Anemia.
- High MCHC is termed hyperchromia, indicating increased hemoglobin concentration, which may lead to health complications like blood clots.
- Spherocytosis: Rare hereditary condition causing abnormally shaped RBCs leads to increased MCHC.
Red Cell Distribution Width (RDW)
- RDW measures the variation in red cell volume and is a more sensitive indicator of altered red cell size than MCV.
- Increased RDW occurs in:
- Regenerative Anemia: Presence of both large and small cells.
- Iron-deficiency Anemia: Variation in cell size indicates multiple cell populations.
- RDW is calculated using the formula: RDW = (SDMCV ÷ MCV) × 100.
Anisocytosis
- Refers to variation in red blood cell sizes, including macrocytes and microcytes.
- Increased anisocytosis occurs with substantial populations of either smaller or larger than normal cells.
Erythrocyte Indices
- Erythrocyte indices, including MCV, MCHC, and RDW, provide critical information on red blood cell size and hemoglobin content.
- These indices are calculated from a complete blood count (CBC) and are essential for diagnosing and managing various types of anemia and hematological conditions.
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Description
This quiz covers the fundamentals of erythrocyte indices, crucial measurements derived from a complete blood count (CBC). Understanding these indices is essential for diagnosing and managing anemia and other hematological conditions in veterinary medicine.