Endosomes and Lysosomes I, II
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Questions and Answers

Which organelle is responsible for the digestion of materials in the cell?

  • Endoplasmic reticulum
  • Golgi apparatus
  • Mitochondria
  • Lysosome (correct)

What is the pH of lysosomes?

  • pH ~ 9.0
  • pH ~ 7.0
  • pH ~ 5.0 (correct)
  • pH ~ 3.0

Which process involves the self-digestion of organelles and proteins by the cell?

  • Phagocytosis
  • Pinocytosis
  • Autophagy (correct)
  • Receptor-mediated endocytosis

What is the main cause of lysosomal storage diseases?

<p>Deficiency in a lysosomal enzyme (C)</p> Signup and view all the answers

Which enzyme is defective in Tay-Sachs Disease?

<p>a-Hexosaminidase A (C)</p> Signup and view all the answers

Which disease is characterized by the accumulation of Glucocerebroside in macrophages?

<p>Gaucher's Disease (B)</p> Signup and view all the answers

Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

<p>Fabry Disease (B)</p> Signup and view all the answers

What is the pH of the lumen in the late endosome?

<p>5.5 (C)</p> Signup and view all the answers

What is the primary function of multivesicular bodies (MVBs)?

<p>Sorting and degradation of integral membrane proteins (C)</p> Signup and view all the answers

Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?

<p>Exocytosis (A)</p> Signup and view all the answers

Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?

<p>Phagocytosis (B)</p> Signup and view all the answers

What is the function of clathrin in the formation of clathrin-coated vesicles?

<p>Captures membrane receptors and bound molecules (B)</p> Signup and view all the answers

What is the GTPase required for the budding of clathrin-coated vesicles?

<p>Dynamin (B)</p> Signup and view all the answers

Which of the following is NOT a mechanism of endocytosis?

<p>Exocytosis (B)</p> Signup and view all the answers

Which of the following is NOT one of the main steps involved in phagocytosis?

<p>Formation of Lysosomes (C)</p> Signup and view all the answers

Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?

<p>Fusion of Vesicles with Lysosomes (C)</p> Signup and view all the answers

Which organelle is responsible for the digestion of materials in the cell?

<p>Lysosome (C)</p> Signup and view all the answers

What is the pH of lysosomes?

<p>pH ~ 5.0 (B)</p> Signup and view all the answers

Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

<p>Tay-Sachs Disease (D)</p> Signup and view all the answers

Which enzyme is defective in Tay-Sachs Disease?

<p>Hexosaminidase A (B)</p> Signup and view all the answers

Which process involves the self-digestion of organelles and proteins by the cell?

<p>Autophagy (C)</p> Signup and view all the answers

What is the primary function of multivesicular bodies (MVBs)?

<p>Recycling of endosomal membrane (C)</p> Signup and view all the answers

Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?

<p>Exocytosis (B)</p> Signup and view all the answers

What is the primary function of multivesicular bodies (MVBs)?

<p>Sorting and recycling of receptors (C)</p> Signup and view all the answers

What is the pH of the lumen in the late endosome?

<p>Slightly acidic (pH 5-6) (B)</p> Signup and view all the answers

What is the GTPase required for the budding of clathrin-coated vesicles?

<p>Dynamin (D)</p> Signup and view all the answers

What is the function of clathrin in the formation of clathrin-coated vesicles?

<p>Captures membrane receptors and bound molecules (D)</p> Signup and view all the answers

Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?

<p>Phagocytosis (A)</p> Signup and view all the answers

Which enzyme is defective in Pompe Disease?

<p>a-D-Glucosidase (C)</p> Signup and view all the answers

Which disease is associated with the accumulation of GM2 Gangliosides in the brain?

<p>Tay-Sachs Disease (A)</p> Signup and view all the answers

Which disease is characterized by the accumulation of Glucocerebroside in macrophages?

<p>Gaucher's Disease (A)</p> Signup and view all the answers

Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

<p>Fabry Disease (A)</p> Signup and view all the answers

Which disease is characterized by the accumulation of Sphingomyelin and impairs formation of lipid rafts in association with cholesterol?

<p>Niemann-Pick Disease (C)</p> Signup and view all the answers

Which enzyme is defective in I-Cell Disease?

<p>a-D-Glucosidase (D)</p> Signup and view all the answers

Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

<p>Gaucher Disease (B)</p> Signup and view all the answers

Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?

<p>Sorting of hydrolytic enzymes (B)</p> Signup and view all the answers

What is the primary function of multivesicular bodies (MVBs)?

<p>Sorting and degradation of integral membrane proteins (D)</p> Signup and view all the answers

What is the main cause of lysosomal storage diseases?

<p>Deficiency of acid hydrolases (A)</p> Signup and view all the answers

Which of the following is NOT one of the main steps involved in phagocytosis?

<p>Formation of a phagosome (B)</p> Signup and view all the answers

Which of the following is NOT a function of dynamin in receptor-mediated endocytosis?

<p>Binding of the ligand to the receptor (A)</p> Signup and view all the answers

Which of the following is NOT a specialization in lysosomal membranes?

<p>Clathrin (A)</p> Signup and view all the answers

Which of the following is the main type of ligand involved in receptor-mediated endocytosis?

<p>Proteins (C)</p> Signup and view all the answers

Which of the following is NOT a role of clathrin in receptor-mediated endocytosis?

<p>Binding of the ligand to the receptor (C)</p> Signup and view all the answers

Which of the following is the main function of multivesicular bodies (MVBs)?

<p>Recycling of membrane proteins (B)</p> Signup and view all the answers

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