44 Questions
Which organelle is responsible for the digestion of materials in the cell?
Lysosome
What is the pH of lysosomes?
pH ~ 5.0
Which process involves the self-digestion of organelles and proteins by the cell?
Autophagy
What is the main cause of lysosomal storage diseases?
Deficiency in a lysosomal enzyme
Which enzyme is defective in Tay-Sachs Disease?
a-Hexosaminidase A
Which disease is characterized by the accumulation of Glucocerebroside in macrophages?
Gaucher's Disease
Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?
Fabry Disease
What is the pH of the lumen in the late endosome?
5.5
What is the primary function of multivesicular bodies (MVBs)?
Sorting and degradation of integral membrane proteins
Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?
Exocytosis
Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?
Phagocytosis
What is the function of clathrin in the formation of clathrin-coated vesicles?
Captures membrane receptors and bound molecules
What is the GTPase required for the budding of clathrin-coated vesicles?
Dynamin
Which of the following is NOT a mechanism of endocytosis?
Exocytosis
Which of the following is NOT one of the main steps involved in phagocytosis?
Formation of Lysosomes
Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?
Fusion of Vesicles with Lysosomes
Which organelle is responsible for the digestion of materials in the cell?
Lysosome
What is the pH of lysosomes?
pH ~ 5.0
Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?
Tay-Sachs Disease
Which enzyme is defective in Tay-Sachs Disease?
Hexosaminidase A
Which process involves the self-digestion of organelles and proteins by the cell?
Autophagy
What is the primary function of multivesicular bodies (MVBs)?
Recycling of endosomal membrane
Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?
Exocytosis
What is the primary function of multivesicular bodies (MVBs)?
Sorting and recycling of receptors
What is the pH of the lumen in the late endosome?
Slightly acidic (pH 5-6)
What is the GTPase required for the budding of clathrin-coated vesicles?
Dynamin
What is the function of clathrin in the formation of clathrin-coated vesicles?
Captures membrane receptors and bound molecules
Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?
Phagocytosis
Which enzyme is defective in Pompe Disease?
a-D-Glucosidase
Which disease is associated with the accumulation of GM2 Gangliosides in the brain?
Tay-Sachs Disease
Which disease is characterized by the accumulation of Glucocerebroside in macrophages?
Gaucher's Disease
Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?
Fabry Disease
Which disease is characterized by the accumulation of Sphingomyelin and impairs formation of lipid rafts in association with cholesterol?
Niemann-Pick Disease
Which enzyme is defective in I-Cell Disease?
a-D-Glucosidase
Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?
Gaucher Disease
Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?
Sorting of hydrolytic enzymes
What is the primary function of multivesicular bodies (MVBs)?
Sorting and degradation of integral membrane proteins
What is the main cause of lysosomal storage diseases?
Deficiency of acid hydrolases
Which of the following is NOT one of the main steps involved in phagocytosis?
Formation of a phagosome
Which of the following is NOT a function of dynamin in receptor-mediated endocytosis?
Binding of the ligand to the receptor
Which of the following is NOT a specialization in lysosomal membranes?
Clathrin
Which of the following is the main type of ligand involved in receptor-mediated endocytosis?
Proteins
Which of the following is NOT a role of clathrin in receptor-mediated endocytosis?
Binding of the ligand to the receptor
Which of the following is the main function of multivesicular bodies (MVBs)?
Recycling of membrane proteins
Test your knowledge on vesicular trafficking and the key players involved, including dynamin, plasma membrane, ligand receptor, AP2, clathrin, recycling to plasma membrane, internalization, clathrin-coated vesicle transport, vesicle lysosome, dissociation of coat, fusion, early endosome, late endosome, trans Golgi network, recycling of Mannose-6-P receptors, and Mannose-6-P tagged lysosomal enzymes.
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