Endosomes and Lysosomes I, II
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Questions and Answers

Which organelle is responsible for the digestion of materials in the cell?

  • Endoplasmic reticulum
  • Golgi apparatus
  • Mitochondria
  • Lysosome (correct)

    • What is the pH of lysosomes?

  • pH ~ 9.0
  • pH ~ 7.0
  • pH ~ 5.0 (correct)
  • pH ~ 3.0

    • Which process involves the self-digestion of organelles and proteins by the cell?

  • Phagocytosis
  • Pinocytosis
  • Autophagy (correct)
  • Receptor-mediated endocytosis

    • What is the main cause of lysosomal storage diseases?

    <p>Deficiency in a lysosomal enzyme</p> Signup and view all the answers

    Which enzyme is defective in Tay-Sachs Disease?

    <p>a-Hexosaminidase A</p> Signup and view all the answers

    Which disease is characterized by the accumulation of Glucocerebroside in macrophages?

    <p>Gaucher's Disease</p> Signup and view all the answers

    Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

    <p>Fabry Disease</p> Signup and view all the answers

    What is the pH of the lumen in the late endosome?

    <p>5.5</p> Signup and view all the answers

    What is the primary function of multivesicular bodies (MVBs)?

    <p>Sorting and degradation of integral membrane proteins</p> Signup and view all the answers

    Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?

    <p>Exocytosis</p> Signup and view all the answers

    Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?

    <p>Phagocytosis</p> Signup and view all the answers

    What is the function of clathrin in the formation of clathrin-coated vesicles?

    <p>Captures membrane receptors and bound molecules</p> Signup and view all the answers

    What is the GTPase required for the budding of clathrin-coated vesicles?

    <p>Dynamin</p> Signup and view all the answers

    Which of the following is NOT a mechanism of endocytosis?

    <p>Exocytosis</p> Signup and view all the answers

    Which of the following is NOT one of the main steps involved in phagocytosis?

    <p>Formation of Lysosomes</p> Signup and view all the answers

    Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?

    <p>Fusion of Vesicles with Lysosomes</p> Signup and view all the answers

    Which organelle is responsible for the digestion of materials in the cell?

    <p>Lysosome</p> Signup and view all the answers

    What is the pH of lysosomes?

    <p>pH ~ 5.0</p> Signup and view all the answers

    Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

    <p>Tay-Sachs Disease</p> Signup and view all the answers

    Which enzyme is defective in Tay-Sachs Disease?

    <p>Hexosaminidase A</p> Signup and view all the answers

    Which process involves the self-digestion of organelles and proteins by the cell?

    <p>Autophagy</p> Signup and view all the answers

    What is the primary function of multivesicular bodies (MVBs)?

    <p>Recycling of endosomal membrane</p> Signup and view all the answers

    Which of the following is NOT one of the main routes for delivery of digestible materials to lysosomes?

    <p>Exocytosis</p> Signup and view all the answers

    What is the primary function of multivesicular bodies (MVBs)?

    <p>Sorting and recycling of receptors</p> Signup and view all the answers

    What is the pH of the lumen in the late endosome?

    <p>Slightly acidic (pH 5-6)</p> Signup and view all the answers

    What is the GTPase required for the budding of clathrin-coated vesicles?

    <p>Dynamin</p> Signup and view all the answers

    What is the function of clathrin in the formation of clathrin-coated vesicles?

    <p>Captures membrane receptors and bound molecules</p> Signup and view all the answers

    Which mechanism of endocytosis involves ingestion of bacteria, large particles, or other cells?

    <p>Phagocytosis</p> Signup and view all the answers

    Which enzyme is defective in Pompe Disease?

    <p>a-D-Glucosidase</p> Signup and view all the answers

    Which disease is associated with the accumulation of GM2 Gangliosides in the brain?

    <p>Tay-Sachs Disease</p> Signup and view all the answers

    Which disease is characterized by the accumulation of Glucocerebroside in macrophages?

    <p>Gaucher's Disease</p> Signup and view all the answers

    Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

    <p>Fabry Disease</p> Signup and view all the answers

    Which disease is characterized by the accumulation of Sphingomyelin and impairs formation of lipid rafts in association with cholesterol?

    <p>Niemann-Pick Disease</p> Signup and view all the answers

    Which enzyme is defective in I-Cell Disease?

    <p>a-D-Glucosidase</p> Signup and view all the answers

    Which disease is associated with the accumulation of Glycosphingolipids in the vascular endothelium of multiple organ systems?

    <p>Gaucher Disease</p> Signup and view all the answers

    Which of the following is NOT a role of clathrin, AP2, and dynamin in receptor-mediated endocytosis?

    <p>Sorting of hydrolytic enzymes</p> Signup and view all the answers

    What is the primary function of multivesicular bodies (MVBs)?

    <p>Sorting and degradation of integral membrane proteins</p> Signup and view all the answers

    What is the main cause of lysosomal storage diseases?

    <p>Deficiency of acid hydrolases</p> Signup and view all the answers

    Which of the following is NOT one of the main steps involved in phagocytosis?

    <p>Formation of a phagosome</p> Signup and view all the answers

    Which of the following is NOT a function of dynamin in receptor-mediated endocytosis?

    <p>Binding of the ligand to the receptor</p> Signup and view all the answers

    Which of the following is NOT a specialization in lysosomal membranes?

    <p>Clathrin</p> Signup and view all the answers

    Which of the following is the main type of ligand involved in receptor-mediated endocytosis?

    <p>Proteins</p> Signup and view all the answers

    Which of the following is NOT a role of clathrin in receptor-mediated endocytosis?

    <p>Binding of the ligand to the receptor</p> Signup and view all the answers

    Which of the following is the main function of multivesicular bodies (MVBs)?

    <p>Recycling of membrane proteins</p> Signup and view all the answers

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