Podcast
Questions and Answers
What is the most common preventable cause of death in hospitalized patients?
What is the most common preventable cause of death in hospitalized patients?
Pulmonary embolism
Which of the following are risk factors for venous thromboembolism (VTE)? (Select all that apply)
Which of the following are risk factors for venous thromboembolism (VTE)? (Select all that apply)
- Antiphospholipid syndrome (correct)
- Tumors (correct)
- Atrial fibrillation (correct)
- Oral contraceptives (correct)
- Cancer (correct)
- Pregnancy (correct)
- Immobilization (correct)
- Catheters (correct)
- Obesity (correct)
What are the main types of heparin used to treat VTE?
What are the main types of heparin used to treat VTE?
- Warfarin
- Low-dose unfractionated heparin (LDUH) (correct)
- Direct oral anticoagulants (DOACs)
- Low-molecular-weight heparin (LMWH) (correct)
Which of the following medications is NOT approved for prophylaxis of venous thromboembolism?
Which of the following medications is NOT approved for prophylaxis of venous thromboembolism?
The international normalized ratio (INR) is a measure of the time it takes for blood to clot.
The international normalized ratio (INR) is a measure of the time it takes for blood to clot.
What is the therapeutic goal of INR for most indications of warfarin use?
What is the therapeutic goal of INR for most indications of warfarin use?
What is the primary role of fondaparinux in the treatment of venous thromboembolism?
What is the primary role of fondaparinux in the treatment of venous thromboembolism?
What are the two main types of heparin-induced thrombocytopenia (HIT)?
What are the two main types of heparin-induced thrombocytopenia (HIT)?
What is the recommended approach to managing a patient with suspected HIT Type II?
What is the recommended approach to managing a patient with suspected HIT Type II?
Direct oral anticoagulants (DOACs) require routine coagulation monitoring.
Direct oral anticoagulants (DOACs) require routine coagulation monitoring.
Which of the following DOACs is most commonly used for the treatment of acute venous thromboembolism?
Which of the following DOACs is most commonly used for the treatment of acute venous thromboembolism?
What is the primary role of idarucizumab?
What is the primary role of idarucizumab?
Which of the following medications is a thrombolytic agent used to treat massive pulmonary embolism?
Which of the following medications is a thrombolytic agent used to treat massive pulmonary embolism?
The term 'bridging' in anticoagulation refers to the use of a parenteral anticoagulant while warfarin therapy reaches therapeutic levels.
The term 'bridging' in anticoagulation refers to the use of a parenteral anticoagulant while warfarin therapy reaches therapeutic levels.
Warfarin is typically more effective and easier to manage than DOACs for the treatment of VTE.
Warfarin is typically more effective and easier to manage than DOACs for the treatment of VTE.
What is the primary goal of anticoagulation therapy for a patient with VTE?
What is the primary goal of anticoagulation therapy for a patient with VTE?
Flashcards
Venous Thromboembolism (VTE)
Venous Thromboembolism (VTE)
A condition involving blood clots in veins, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
Deep Vein Thrombosis (DVT)
Deep Vein Thrombosis (DVT)
A blood clot that forms in a deep vein, often in the legs.
Pulmonary Embolism (PE)
Pulmonary Embolism (PE)
A blood clot that travels to the lungs and blocks blood flow.
Thrombosis
Thrombosis
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Embolism
Embolism
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Blood Clot
Blood Clot
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VTE Risk Factors
VTE Risk Factors
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Anticoagulants
Anticoagulants
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Warfarin
Warfarin
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Direct Oral Anticoagulants (DOACs)
Direct Oral Anticoagulants (DOACs)
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Heparin
Heparin
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LMWH
LMWH
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Mortality from PE
Mortality from PE
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QOL
QOL
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Post-thrombotic syndrome
Post-thrombotic syndrome
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Chronic Venous Insufficiency
Chronic Venous Insufficiency
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Platelet Aggregation
Platelet Aggregation
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Clotting Cascade
Clotting Cascade
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Factor X
Factor X
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Factor II
Factor II
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Study Notes
Venous Thromboembolism (VTE)
- VTE describes pathophysiological events in which blood clots form within the veins, most commonly the deep veins of the lower extremities.
- Key characteristics of VTE include thrombosis (formation of a fibrin clot), deep vein thrombosis (DVT), and pulmonary embolism (PE).
- Risk factors of VTE often relate to blood flow, clotting components, and endothelial surfaces, which can be related to immobility, hypercoagulable states, and injuries to blood vessels.
- Virchow's triad is a useful model to consider risk factors (changes in blood flow, changes in the blood, and abnormalities in the vessel wall)
- Management of VTE often involves anticoagulants.
- Anticoagulant treatments are crucial and specific patient characteristics and medical history must be considered to tailor treatment regimens.
- Low-dose unfractionated heparin (LDUH)
- Low molecular weight heparin (LMWH)
- Direct oral anticoagulants (DOACs)
- Warfarin
- Monitoring plans regarding drug efficacy and adverse events are essential.
- Treatment failures and adverse events require alternative treatment and monitoring regimens.
- Common goals of treatment include preventing distal oxygen delivery, preventing clot extension proximally/retrograde.
- Typical treatments, side effects, and contraindications to anticoagulants are discussed.
Definitions
- Thrombosis: Formation of a blood clot within a blood vessel (not inherently "bad").
- Deep Vein Thrombosis (DVT): Blood clot formation within the deep veins, usually of the lower extremities.
- Pulmonary Embolism (PE): A clot that breaks off from a DVT and travels to the lungs, blocking blood flow. The primary complication of DVT.
- Heparin: An anticoagulant commonly used to treat VTE, usually unfractionated heparin or low molecular weight heparin.
- DOAC: A direct oral anticoagulant, a newer class of anticoagulants.
- Warfarin: A vitamin K antagonist, an older class of anticoagulants.
Presentation
- DVT symptoms: Unilateral leg swelling, warmth, tenderness, pain, Homans' sign (pain in calf with dorsiflexion of foot), may be asymptomatic.
- PE symptoms: Tachypnea, tachycardia, dyspnea, pleuritic chest pain, anxiety, cough, hemoptysis.
- Tests and diagnostic tools such as D-dimer (sensitive but not specific), duplex/Doppler/ultrasound, CT angiography, and V/Q scan are used.
Prevention
- Every hospitalized patient should be assessed for VTE risk. This assessment includes non-pharmacological as well as pharmacological methods.
- Nonpharmacological methods may include graduated compression stockings, intermittent pneumatic compression devices (IPC), and exercise routines to promote blood circulation.
Treatment
- General approach: Initial therapy and long-term therapy with an overlap period when switching agents.
- Choosing an agent: Consideration of patient factors (presence of cancer or other conditions) and guidelines for extended therapy duration play a critical role in treatment selection.
Monitoring
- Monitor for overt signs of bleeding, blood in urine or stool, or decrease in hemoglobin/hematocrit.
- Laboratory values—complete blood count (CBC), coagulation panel (PT, INR, aPTT)—are necessary to assess for potential issues.
Additional Notes
- The use of different anticoagulants, such as fondaparinux, enoxaparin, warfarin, and Dabigatran is described.
- Reversal agents are also noted for scenarios of bleeding, or other issues.
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