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Questions and Answers
What is the function of the conserved heptamer and nonamer sequences in RSSs?
What is the function of the conserved heptamer and nonamer sequences in RSSs?
- They catalyze the recombination process.
- They are essential for binding to the recombinase enzyme complex. (correct)
- They determine the spacer lengths.
- They align the RSSs properly during recombination.
Why is it important for the spacer regions to have specific lengths in V(D)J recombination?
Why is it important for the spacer regions to have specific lengths in V(D)J recombination?
- To increase the diversity of the immune repertoire.
- To ensure proper alignment of the RSSs during recombination. (correct)
- To determine the gene segments that will undergo recombination.
- To catalyze the recombination process.
What does the 12/23 rule dictate in V(D)J recombination?
What does the 12/23 rule dictate in V(D)J recombination?
- Recombination can only occur between gene segments with different spacer lengths. (correct)
- Recombination is independent of the spacer lengths between gene segments.
- Recombination must involve at least one identical RSS.
- Recombination can only occur between gene segments with the same spacer length.
How does the 23-nucleotide spacer differ from the 12-nucleotide spacer in V(D)J recombination?
How does the 23-nucleotide spacer differ from the 12-nucleotide spacer in V(D)J recombination?
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In V(D)J recombination, what role do proteins like RAG1 and RAG2 play?
In V(D)J recombination, what role do proteins like RAG1 and RAG2 play?
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How does proper alignment of RSSs during V(D)J recombination help increase immune repertoire diversity?
How does proper alignment of RSSs during V(D)J recombination help increase immune repertoire diversity?
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