V(D)J Recombination Mechanism
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Questions and Answers

What is the function of the conserved heptamer and nonamer sequences in RSSs?

  • They catalyze the recombination process.
  • They are essential for binding to the recombinase enzyme complex. (correct)
  • They determine the spacer lengths.
  • They align the RSSs properly during recombination.

    • Why is it important for the spacer regions to have specific lengths in V(D)J recombination?

  • To increase the diversity of the immune repertoire.
  • To ensure proper alignment of the RSSs during recombination. (correct)
  • To determine the gene segments that will undergo recombination.
  • To catalyze the recombination process.

    • What does the 12/23 rule dictate in V(D)J recombination?

  • Recombination can only occur between gene segments with different spacer lengths. (correct)
  • Recombination is independent of the spacer lengths between gene segments.
  • Recombination must involve at least one identical RSS.
  • Recombination can only occur between gene segments with the same spacer length.

    • How does the 23-nucleotide spacer differ from the 12-nucleotide spacer in V(D)J recombination?

    <p>The 23-nucleotide spacer corresponds to one turn of the DNA helix, while the 12-nucleotide spacer corresponds to two turns.</p> Signup and view all the answers

    In V(D)J recombination, what role do proteins like RAG1 and RAG2 play?

    <p>Catalyzing the recombination process.</p> Signup and view all the answers

    How does proper alignment of RSSs during V(D)J recombination help increase immune repertoire diversity?

    <p>By facilitating the joining of different gene segments.</p> Signup and view all the answers

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