6 Questions
What is the function of the conserved heptamer and nonamer sequences in RSSs?
They are essential for binding to the recombinase enzyme complex.
Why is it important for the spacer regions to have specific lengths in V(D)J recombination?
To ensure proper alignment of the RSSs during recombination.
What does the 12/23 rule dictate in V(D)J recombination?
Recombination can only occur between gene segments with different spacer lengths.
How does the 23-nucleotide spacer differ from the 12-nucleotide spacer in V(D)J recombination?
The 23-nucleotide spacer corresponds to one turn of the DNA helix, while the 12-nucleotide spacer corresponds to two turns.
In V(D)J recombination, what role do proteins like RAG1 and RAG2 play?
Catalyzing the recombination process.
How does proper alignment of RSSs during V(D)J recombination help increase immune repertoire diversity?
By facilitating the joining of different gene segments.
Learn about the mechanism of V(D)J recombination, focusing on Recombination Signal Sequences (RSSs) with conserved heptamer and nonamer sequences, recognition of specific residues within these sequences, and the importance of spacer lengths between them. Explore how proteins like RAG1 and RAG2 are involved in catalyzing the recombination process.
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