7 Questions
What is the role of Recombination Signal Sequences (RSSs) in V(D)J recombination?
Bind to recombinase enzymes like RAG1 and RAG2
Why are specific residues within the heptamer and nonamer sequences important in V(D)J recombination?
To bind to the recombinase enzyme complex
What is the significance of the 12/23 Rule in V(D)J recombination?
It ensures that recombination occurs between gene segments with different spacer lengths
What role do the spacer regions play in V(D)J recombination?
Align the Recombination Signal Sequences (RSSs) properly
How do different spacer lengths contribute to V(D)J recombination?
Ensure proper alignment of Recombination Signal Sequences
Why is it crucial for the spacer regions to have specific lengths in V(D)J recombination?
To facilitate proper alignment of RSSs during recombination
How does the heptamer and nonamer recognition contribute to V(D)J recombination?
Ensure proper binding to recombinase enzymes like RAG1 and RAG2
Learn about the mechanism of V(D)J recombination, focusing on the composition of Recombination Signal Sequences (RSSs) and the recognition of heptamer and nonamer sequences. Understand the crucial role of specific residues in binding to the recombinase enzyme complex and catalyzing the recombination process.
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