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Questions and Answers
What is the role of Recombination Signal Sequences (RSSs) in V(D)J recombination?
What is the role of Recombination Signal Sequences (RSSs) in V(D)J recombination?
- Bind to recombinase enzymes like RAG1 and RAG2 (correct)
- Facilitate transcription of the gene segments
- Directly code for the immunoglobulin gene sequence
- Control the expression of the immune repertoire
Why are specific residues within the heptamer and nonamer sequences important in V(D)J recombination?
Why are specific residues within the heptamer and nonamer sequences important in V(D)J recombination?
- To initiate transcription of the gene segments
- To regulate the immune repertoire diversity
- To encode for the spacer regions
- To bind to the recombinase enzyme complex (correct)
What is the significance of the 12/23 Rule in V(D)J recombination?
What is the significance of the 12/23 Rule in V(D)J recombination?
- It determines the order of gene segments in the DNA
- It encodes for the heptamer and nonamer sequences
- It ensures that recombination occurs between gene segments with different spacer lengths (correct)
- It controls the transcription process of the immune genes
What role do the spacer regions play in V(D)J recombination?
What role do the spacer regions play in V(D)J recombination?
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How do different spacer lengths contribute to V(D)J recombination?
How do different spacer lengths contribute to V(D)J recombination?
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Why is it crucial for the spacer regions to have specific lengths in V(D)J recombination?
Why is it crucial for the spacer regions to have specific lengths in V(D)J recombination?
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How does the heptamer and nonamer recognition contribute to V(D)J recombination?
How does the heptamer and nonamer recognition contribute to V(D)J recombination?
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