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V(D)J Rearrangement in Antibody Production

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V(D)J Rearrangement in Antibody Production

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Questions and Answers

Which enzymes are involved in the recognition and synapsis of DNA ends during V(D)J recombination?

TdT

DNA ligase IV/XRCC4

Artemis/DNA-PKcs/Ku79/Ku80 (correct)

DNA-PKcs/Ku79/Ku80

What is the function of TdT in V(D)J recombination?

Ligate cut DNA ends

Add random nucleotides to coding ends (correct)

Remove unpaired bases from coding ends

Recognize RSS sequences

What is the role of Artemis in V(D)J recombination?

Joining DNA ends

Removing unpaired bases from coding ends

Opening coding end hairpins (correct)

Adding extra nucleotides at VDJ junctions

Which proteins form a complex that recognizes and closes DNA ends during V(D)J recombination?

Artemis/DNA-PKcs/Ku79/Ku80 Signup and view all the answers

What initiates the DNA cleavage at randomly selected RSS during V(D)J recombination?

RSS recognition by RAG1, RAG2 proteins Signup and view all the answers

Which process involves the formation of coding joints and signal end joints during V(D)J recombination?

Looping of DNA to delete all intervening DNA Signup and view all the answers

Which enzyme is responsible for joining DNA ends by aligning them and recruiting TdT enzyme?

DNA ligase IV/XRCC4 Signup and view all the answers

'Real' Ig Light chain pairs with the Ig Heavy chain to form what complex?

'B cell' complex Signup and view all the answers

'Surrogate Light Chains' pair with which chain to form the pre-B cell receptor?

'Ig Heavy' chain Signup and view all the answers

'Class switch recombination' directs changes in the constant region of antibodies under the influence of which cells?

'Helper T cells' Signup and view all the answers

What is responsible for adding extra (random) nucleotides to broken ends at VDJ junctions mostly in Heavy chains?

TdT (terminal deoxynucleotidyl transferase) Signup and view all the answers