11 Questions
Which enzymes are involved in the recognition and synapsis of DNA ends during V(D)J recombination?
Artemis/DNA-PKcs/Ku79/Ku80
What is the function of TdT in V(D)J recombination?
Add random nucleotides to coding ends
What is the role of Artemis in V(D)J recombination?
Opening coding end hairpins
Which proteins form a complex that recognizes and closes DNA ends during V(D)J recombination?
Artemis/DNA-PKcs/Ku79/Ku80
What initiates the DNA cleavage at randomly selected RSS during V(D)J recombination?
RSS recognition by RAG1, RAG2 proteins
Which process involves the formation of coding joints and signal end joints during V(D)J recombination?
Looping of DNA to delete all intervening DNA
Which enzyme is responsible for joining DNA ends by aligning them and recruiting TdT enzyme?
DNA ligase IV/XRCC4
'Real' Ig Light chain pairs with the Ig Heavy chain to form what complex?
'B cell' complex
'Surrogate Light Chains' pair with which chain to form the pre-B cell receptor?
'Ig Heavy' chain
'Class switch recombination' directs changes in the constant region of antibodies under the influence of which cells?
'Helper T cells'
What is responsible for adding extra (random) nucleotides to broken ends at VDJ junctions mostly in Heavy chains?
TdT (terminal deoxynucleotidyl transferase)
Learn about the process of V(D)J rearrangement in antibody production, where the variable regions are coded by V region DNA and rearranged in a specific order. Understand the role of H chain and L chain loci, as well as the mechanism of receptor editing during antibody production.
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