Vasopressin Flashcards

Study Notes

Vasopressin Overview

Vasopressin is classified as a hormone and vasopressor, primarily involved in regulating blood pressure.

Mechanism of Action (MOA)

Acts as a non-alpha-adrenergic vasoconstrictor at higher doses.
Stimulates smooth muscle receptors directly, influencing vascular tone.
Can serve as an alternative to epinephrine in cardiopulmonary resuscitation (CPR).

Pharmacokinetics

Onset and peak effects are variable, depending on individual responses.
Duration of action ranges from 30 to 60 minutes.
Half-life is between 20 to 30 minutes, indicating the time taken for the drug's effects to reduce by half.

Generic Name

Under the brand name "Pitressin," it is widely recognized in the medical field.

Indications for Use

Primarily indicated for increasing peripheral vascular resistance during CPR.
Can be given when epinephrine is not effective or has already been administered.

Contraindications

Contraindicated in individuals with chronic nephritis, ischemic heart disease, premature ventricular contractions (PVCs), and advanced arteriosclerosis.
During CPR, typical contraindications may not apply, allowing for its use in critical situations.

Side Effects

Common adverse effects include:
- Abdominal cramps
- Angina (chest pain)
- Asthma exacerbation
- Blanching of the skin
- Heart failure
- Hypertension (high blood pressure)
- Nausea

Dosage

Adult dosage is 40 units administered intravenously as a single dose.
Pediatric dosage and administration specifics for cardiac arrest are not detailed.

Description

This quiz focuses on vasopressin, a crucial hormone known for its vasoconstrictive properties. Each card covers different aspects including its mechanism of action and pharmacokinetics. Test your knowledge on this important substance used in critical medical situations.