Vaccines, immunostimulants and immunomodulators  Overview Quiz

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Questions and Answers

What type of vaccine is the Meningococcal B Vaccine?

  • Inactivated vaccine
  • Recombinant vaccine (correct)
  • Polysaccharide vaccine
  • Live attenuated vaccine

Which of the following is an adverse reaction associated with the Human Papillomavirus (HPV) Vaccine?

  • Severe fever
  • Mild rash
  • Injection site pain (correct)
  • Severe headache

What is a common contraindication for the Measles Vaccine?

  • Hypersensitivity to components (correct)
  • Acute respiratory illness
  • Recent surgery
  • Infant age less than 6 months

Which preventable disease is targeted by the Pneumococcal Vaccine?

<p>Bacteremia (D)</p> Signup and view all the answers

What interaction may reduce the efficacy of the Meningococcal Vaccine?

<p>Immunosuppressants (D)</p> Signup and view all the answers

The Varicella Vaccine is classified as which type of vaccine?

<p>Live attenuated vaccine (B)</p> Signup and view all the answers

Which adverse reaction is specific to the Meningococcal Vaccine?

<p>Fatigue (D)</p> Signup and view all the answers

What is a contraindication for the Meningococcal B Vaccine?

<p>Hypersensitivity to components (A)</p> Signup and view all the answers

Which disease does the Measles Vaccine aim to prevent?

<p>Rubeola (D)</p> Signup and view all the answers

Which vaccine is designed to induce immunity against the Streptococcus pneumoniae bacteria?

<p>Pneumococcal Vaccine (B)</p> Signup and view all the answers

What is a common adverse reaction associated with Filgrastim?

<p>Injection site pain (C)</p> Signup and view all the answers

Which condition is a contraindication for using Epoetin Alfa?

<p>Uncontrolled hypertension (C)</p> Signup and view all the answers

What action does Leucovorin perform?

<p>Protects cells from methotrexate toxicity (A)</p> Signup and view all the answers

Which of the following medications is classified as a vitamin?

<p>Cyanocobalamin (B)</p> Signup and view all the answers

What potential interaction should be considered when administering Folic Acid?

<p>May reduce the efficacy of anticonvulsants (D)</p> Signup and view all the answers

A patient with which condition should avoid Leucovorin?

<p>Pernicious anemia (A)</p> Signup and view all the answers

Which adverse reaction is rare for Cyanocobalamin?

<p>Injection site reactions (A)</p> Signup and view all the answers

What is the action of Folic Acid?

<p>Essential for DNA synthesis (A)</p> Signup and view all the answers

What classification does Epoetin Alfa belong to?

<p>Erythropoiesis-stimulating agent (C)</p> Signup and view all the answers

Which of the following is a significant contraindication of Filgrastim?

<p>hypothyroid disease (A)</p> Signup and view all the answers

What is a common adverse reaction associated with the Zoster vaccine?

<p>Fatigue (B)</p> Signup and view all the answers

Which of the following is a contraindication for the Rabies vaccine?

<p>Hypersensitivity to components (D)</p> Signup and view all the answers

How is the Diphtheria, Tetanus, Pertussis (DTaP/Tdap) vaccine classified?

<p>Inactivated bacterial toxoid and subunit vaccine (C)</p> Signup and view all the answers

What disease does the Tetanus Toxoid vaccine aim to prevent?

<p>Tetanus (B)</p> Signup and view all the answers

Which vaccine requires avoidance of salicylates for 6 weeks post-administration?

<p>Zoster vaccine (A)</p> Signup and view all the answers

What is a known adverse reaction when receiving immune globulin (Rh Immune Globulin)?

<p>Local reactions (C)</p> Signup and view all the answers

What precaution must be taken when administering the Zoster vaccine?

<p>Do not administer to pregnant women (D)</p> Signup and view all the answers

Which of the following interactions can affect the response to the Rabies vaccine?

<p>Immune globulins (A)</p> Signup and view all the answers

For which patient condition is the Antivenin specifically indicated?

<p>Envenomation from bites/stings (A)</p> Signup and view all the answers

What action does the Rh Immune Globulin (IGIM) serve in Rh-negative individuals?

<p>Prevents Rh sensitization (C)</p> Signup and view all the answers

What is the primary action of the Rabies vaccine?

<p>Stimulates antibody production to prevent rabies infection (D)</p> Signup and view all the answers

Which adverse reactions are commonly associated with the Zoster vaccine?

<p>Injection site pain, fatigue, headache (B)</p> Signup and view all the answers

What is a significant contraindication for the Diphtheria, Tetanus, Pertussis vaccine?

<p>History of encephalopathy with pertussis-containing vaccine (C)</p> Signup and view all the answers

Which classification does the Zoster vaccine fall under?

<p>Recombinant or live vaccine (A)</p> Signup and view all the answers

What is a primary use of Rh Immune Globulin (IGIM)?

<p>Prevention of hemolytic disease of the newborn (after birth) (B)</p> Signup and view all the answers

Which of the following is a known interaction with the Rabies vaccine?

<p>Immune globulins may affect the vaccine response (C)</p> Signup and view all the answers

What is a precaution for administering the Tetanus Toxoid vaccine?

<p>Avoid in patients with hypersensitivity to components (D)</p> Signup and view all the answers

Which adverse reaction is most likely associated with the Antivenin treatment?

<p>Pain at the injection site (C)</p> Signup and view all the answers

What is the action of the Diphtheria, Tetanus, Pertussis vaccine?

<p>Immunity against tetanus toxin (D)</p> Signup and view all the answers

Which interaction is advised to avoid following Zoster vaccination?

<p>Other live vaccines for 6 weeks (B)</p> Signup and view all the answers

What is the primary action of Epoetin Alfa?

<p>Stimulates red blood cell production (A)</p> Signup and view all the answers

Which medication is indicated for treating megaloblastic anemia?

<p>Leucovorin (A), Cyanocobalamin (C)</p> Signup and view all the answers

What is a significant contraindication for using Filgrastim?

<p>Hypersensitivity to E.coli-derived proteins (B)</p> Signup and view all the answers

Which of the following adverse reactions is most commonly associated with Epoetin Alfa?

<p>Hypertension (A)</p> Signup and view all the answers

What common adverse reaction may occur with Folic Acid supplementation?

<p>few adverse reactions are associated w/ administration of folic acid. (D)</p> Signup and view all the answers

Which medication protects normal cells from methotrexate toxicity?

<p>Leucovorin (B)</p> Signup and view all the answers

What potential interaction should be considered with Cyanocobalamin?

<p>Anticonvulsants may reduce efficacy (C)</p> Signup and view all the answers

What is a common contraindication for Cyanocobalamin?

<p>Optic nerve atrophy (A)</p> Signup and view all the answers

Which action does Folic Acid perform?

<p>Essential for DNA synthesis (B)</p> Signup and view all the answers

What adverse reaction may occur due to Leucovorin administration?

<p>Allergic reactions (A)</p> Signup and view all the answers

What is a primary use of the Meningococcal Vaccine?

<p>Prevention of meningitis (D)</p> Signup and view all the answers

Which type of vaccine is the Varicella Vaccine classified as?

<p>Live attenuated vaccine (D)</p> Signup and view all the answers

What is a significant interaction associated with the Measles Vaccine?

<p>Immune globulins may interfere with efficacy (A)</p> Signup and view all the answers

Which adverse reaction is common after receiving the Pneumococcal Vaccine?

<p>Local reactions at the injection site (D)</p> Signup and view all the answers

What action does the Human Papillomavirus (HPV) Vaccine promote?

<p>Prevents HPV infections and associated conditions (B)</p> Signup and view all the answers

What common contraindication is shared by both the Meningococcal Vaccine and the Meningococcal B Vaccine?

<p>Hypersensitivity to components (A)</p> Signup and view all the answers

Which of the following conditions renders a person at risk of reduced efficacy with the Pneumococcal Vaccine?

<p>Immunosuppressive therapy (C)</p> Signup and view all the answers

Which vaccination is specifically designed to prevent infections caused by serogroup B Neisseria meningitidis?

<p>Meningococcal B Vaccine (D)</p> Signup and view all the answers

Which of these is NOT considered an adverse reaction to the Varicella Vaccine?

<p>Fatigue (C)</p> Signup and view all the answers

Which substance is specifically mentioned as a contraindication for the measles, mumps, rubella, and varicella vaccines?

<p>Gelatin (A)</p> Signup and view all the answers

What is a key concern regarding the administration of the measles, mumps, rubella, and varicella vaccines during pregnancy?

<p>Potential for birth defects (D)</p> Signup and view all the answers

How long should women avoid becoming pregnant after receiving the measles, mumps, rubella, or varicella vaccines?

<p>3 months (B)</p> Signup and view all the answers

Which of the following describes a common allergic reaction that would contraindicate the measles, mumps, rubella, or varicella vaccines?

<p>Allergy to neomycin (A)</p> Signup and view all the answers

What is a contraindication for the measles, mumps, rubella, and varicella vaccines in terms of patient history?

<p>Previous dose reaction to the vaccines (B)</p> Signup and view all the answers

Flashcards

Zoster Vaccine Classification

A vaccine that is either recombinant or live, reducing the risk of shingles.

Zoster Vaccine Use

Preventing shingles in older adults.

Rabies Vaccine Classification

An inactivated vaccine that stimulates the production of antibodies for prevention of rabies.

Rabies Vaccine Use

Pre- and post-exposure prophylaxis.

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DTaP/Tdap Classification

An inactivated bacterial toxoid and subunit vaccine providing immunity against diphtheria, tetanus, and pertussis.

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DTaP/Tdap Use

Routine childhood immunization and booster for adults.

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Rh Immune Globulin Action

Prevents Rh sensitization in Rh-negative individuals.

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Rh Immune Globulin Use

Preventing hemolytic disease of the newborn.

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Tetanus Toxoid Action

Induces tetanus immunity by targeting the tetanus toxin.

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Antivenin Classification

An antitoxin that neutralizes specific venom from bites.

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Meningococcal Vaccine

A vaccine that protects against Neisseria meningitidis, preventing meningitis and meningococcal disease.

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Meningococcal B Vaccine

A vaccine targeting serogroup B Neisseria meningitidis, preventing meningococcal group B infection.

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Pneumococcal Vaccine

A vaccine preventing pneumonia, meningitis, and bacteremia caused by Streptococcus pneumoniae.

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Measles Vaccine

A vaccine that gives immunity against measles virus preventing measles.

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HPV Vaccine

A vaccine that prevents HPV infections, reducing risk of cervical cancer and genital warts.

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Varicella Vaccine

A vaccine that induces immunity against varicella-zoster virus preventing chickenpox.

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Inactivated Vaccine

A vaccine that uses a deactivated form of a virus.

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Recombinant Vaccine

A vaccine produced using genetic engineering techniques.

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Filgrastim Classification

A colony-stimulating factor that stimulates neutrophil production.

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Live Attenuated Vaccine

A vaccine using a weakened form of a microorganism.

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Filgrastim Use

Treats neutropenia in patients undergoing chemotherapy or bone marrow transplantation.

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Polysaccharide or conjugate vaccine

A vaccine using sugars or a combination of sugars and proteins to trigger an immune response.

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Folic Acid Action

Essential for DNA synthesis and red blood cell production.

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Folic Acid Uses

Treats megaloblastic anemia and is used as a supplement during pregnancy.

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Leucovorin Action

Protects normal cells from the toxic effects of methotrexate.

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Leucovorin Uses

Used as rescue therapy for methotrexate toxicity and for folate deficiency anemia.

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Epoetin Alfa Action

Stimulates the production of red blood cells.

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Epoetin Alfa Uses

Treats anemia in patients with chronic kidney disease and those undergoing chemotherapy.

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Cyanocobalamin (Vitamin B12) Action

Vital for DNA synthesis and red blood cell maturation.

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Cyanocobalamin (Vitamin B12) Uses

Treats pernicious anemia and other vitamin B12 deficiencies.

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Meningococcal Vaccine Type

The meningococcal vaccine is an inactivated vaccine, meaning it uses a weakened or killed form of the bacteria to stimulate an immune response.

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Meningococcal Vaccine Protection

The meningococcal vaccine protects against Neisseria meningitidis, a bacteria that can cause serious infections like meningitis and meningococcal disease.

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Meningococcal B Vaccine Target

The meningococcal B vaccine specifically targets serogroup B Neisseria meningitidis, a specific strain of the bacteria.

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Pneumococcal Vaccine Action

The pneumococcal vaccine induces immunity against Streptococcus pneumoniae, a common bacteria that can cause various infections.

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Measles Vaccine Classification

The measles vaccine is a live attenuated vaccine, meaning it contains a weakened form of the measles virus.

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HPV Vaccine Action

The HPV vaccine prevents infections caused by the human papillomavirus (HPV) and associated conditions like cervical cancer.

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Varicella Vaccine Target

The varicella vaccine induces immunity against the varicella-zoster virus which causes chickenpox.

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Common Vaccine Side Effects

Many vaccines can cause common side effects like pain at the injection site, fever, headache, and fatigue.

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Vaccine Contraindications

Vaccines should not be given to people with hypersensitivity to components, and should be deferred during acute illness.

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Vaccine Interaction

Immunosuppressants, medications that weaken the immune system, can reduce the effectiveness of certain vaccines.

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Zoster Vaccine Action

It reduces the risk of developing herpes zoster (shingles) by stimulating the immune system to fight the varicella-zoster virus.

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Zoster Vaccine Contraindications

Individuals with severe immunocompromise should not receive this vaccine because their weakened immune systems might not respond properly or could even be harmed by the live virus in the vaccine.

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Rabies Vaccine Action

It works by stimulating your body to produce antibodies against the rabies virus, protecting you from infection.

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DTaP/Tdap Vaccine Action

It provides immunity against three serious diseases: diphtheria, tetanus, and pertussis (whooping cough).

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DTaP/Tdap Vaccine Use

It is a primary immunization for children and a booster shot for adults to maintain protection against these diseases.

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Antivenin Action

It works by neutralizing the venom from specific bites or stings, preventing the venom from causing harm.

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What is Filgrastim?

Filgrastim is a colony-stimulating factor that stimulates the production of neutrophils, a type of white blood cell that fights infections.

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What are the uses of Filgrastim?

Filgrastim is used to treat neutropenia, a condition of low neutrophil count, which often occurs during chemotherapy or bone marrow transplantation.

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What are the adverse reactions of Filgrastim?

Common adverse reactions to Filgrastim include bone pain, fever, and injection site pain.

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What is Folic Acid?

Folic Acid is a vital vitamin that is crucial for DNA synthesis and red blood cell production.

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What are the uses of Folic Acid?

Folic Acid is used to treat megaloblastic anemia, a type of anemia caused by faulty red blood cell production, and is also essential during pregnancy.

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What is Leucovorin?

Leucovorin is a derivative of folic acid that protects normal cells from the toxic effects of the medication methotrexate.

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What are the uses of Leucovorin?

Leucovorin is used as a rescue therapy to counteract the toxicity of methotrexate and also to treat folate deficiency anemia.

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What is Epoetin Alfa?

Epoetin Alfa is an erythropoiesis-stimulating agent that promotes the production of red blood cells.

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What are the uses of Epoetin Alfa?

Epoetin Alfa is used to treat anemia in patients with chronic kidney disease and those undergoing chemotherapy.

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What is Cyanocobalamin?

Cyanocobalamin, also known as Vitamin B12, is essential for DNA synthesis and red blood cell maturation.

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Measles, Mumps, Rubella, Varicella Vaccine Contraindication

These vaccines are not given to individuals who have had an allergic reaction to gelatin, neomycin, or a previous dose of the vaccine. They are also contraindicated during pregnancy, particularly in the first trimester, due to the risk of birth defects.

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Measles, Mumps, Rubella, Varicella Vaccine Post-Vaccination Precautions

Women who receive these vaccines must avoid becoming pregnant for at least 3 months after vaccination, as this is the timeframe within which a potential risk of birth defects exists.

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What are contraindications?

Contraindications are specific situations or conditions that make it unsafe or inadvisable to administer a particular medication or treatment, in this case, the MMRV vaccines.

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Why avoid pregnancy after MMRV vaccines?

The risk of birth defects from the MMRV vaccines is highest during the first trimester of pregnancy. To minimize this risk, women are instructed to avoid pregnancy for at least 3 months following vaccination.

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Why are these vaccines contraindicated in those with gelatin or neomycin allergies?

These vaccines contain gelatin and neomycin as components. Individuals allergic to these substances may experience severe reactions, including anaphylaxis, after receiving the vaccine.

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Study Notes

Vaccines

  • Meningococcal Vaccine (adolescent): Inactivated vaccine; stimulates immunity against Neisseria meningitidis; prevents meningitis and meningococcal disease; adverse reactions include pain at injection site, fever, headache, and fatigue. Immunosuppressants may reduce vaccine efficacy.

  • Meningococcal B Vaccine: Recombinant vaccine targets serogroup B Neisseria meningitidis; prevents meningococcal group B infection; adverse reactions include injection site reactions, fatigue, and fever. Efficacy may be reduced by immunosuppressants.

  • Pneumococcal Vaccine: Polysaccharide or conjugate vaccine; induces immunity against Streptococcus pneumoniae; prevents pneumonia, meningitis, and bacteremia; adverse reactions include local reactions and fever. Avoid use in immunocompromised patients; immunosuppressants may reduce efficacy.

  • Measles Vaccine: Live attenuated vaccine; provides immunity to measles virus; prevents measles; potential adverse reactions include fever, rash, and mild lymphadenopathy; avoid use in pregnancy, or severe immunodeficiency. Interactions with immune globulins are possible.

  • Human Papillomavirus (HPV) Vaccine: Recombinant vaccine; prevents HPV infections and associated conditions like cervical cancer; prevents HPV-related cancers and genital warts; adverse reactions include injection site pain, headache, and fever. Hypersensitivity to vaccine components is a contraindication.

Varicella Vaccine

  • Live attenuated vaccine; induces immunity against varicella-zoster virus; prevents chickenpox. Potential adverse effects include rash, fever, and injection site reactions. Pregnancy and severe immunodeficiency are contraindications. Avoid salicylates for 6 weeks after vaccination.

Zoster Vaccine

  • Recombinant or live vaccine reduces the risk of herpes zoster (shingles); prevents shingles in older adults; potential adverse effects include injection site pain, fatigue, headache. Contraindicated for severe immunocompromised individuals (for live vaccine).

Rabies Vaccine

  • Inactivated vaccine; prevents rabies infection by stimulating antibody production. Used for pre- and post-exposure prophylaxis. Adverse reactions include pain, fever, and malaise. Hypersensitivity to vaccine components may be a contraindication; interactions with immune globulins are possible.

Diphtheria, Tetanus, Pertussis (DTaP/Tdap) Vaccine

  • Inactivated bacterial toxoid vaccine; creates immunity against diphtheria, tetanus, and pertussis; routine childhood immunization; and booster for adults; adverse reactions include injection site reactions, fever, and irritability.

Rh Immune Globulin (RIG, IGIV)

  • Immune globulin, prevents Rh sensitization in Rh-negative individuals; prevents hemolytic disease of the newborn; potential adverse reactions include local reactions, fever, and urticaria. Live vaccines may be less effective after administration; hypersensitivity to immunoglobulin is a contraindication.

Tetanus Toxoid Vaccine

  • Inactivated bacterial toxoid; creates tetanus immunity; prevents tetanus; adverse reactions include injection site pain and fever; hypersensitivity to toxoid is a contraindication.

Antivenin (Antitoxin)

  • Antitoxin; neutralizes venom from specific animal bites/stings; used to treat envenomation (e.g., snakebite, spider bite). Potential adverse reactions include hypersensitivity and serum sickness. Hypersensitivity to equine or ovine proteins should be considered a contraindication.

Medications

Filgrastim

  • Colony-stimulating factor; stimulates neutrophil production; used in neutropenia during chemotherapy or bone marrow transplantation.; potential adverse reactions include bone pain, fever, and injection site pain. Hypersensitivity to E. coli-derived proteins should be considered.

Folic Acid

  • Vitamin; essential for DNA synthesis and red blood cell production; used for megaloblastic anemia and pregnancy supplementation; potential adverse reactions may be rare (rash or bronchospasm). Avoid use with known anticonvulsants due to reduced efficacy.

Leucovorin

  • Folic acid derivative; protects cells from methotrexate toxicity; used in methotrexate rescue therapy and folate deficiency anemia; potential adverse reactions include allergic reactions and rash. Avoid use in patients with pernicious anemia.

Epoetin Alfa

  • Erythropoiesis-stimulating agent; stimulates red blood cell production; used for anemia from chronic kidney disease or chemotherapy; potential adverse reactions include hypertension and thrombosis; uncontrolled hypertension is a contraindication.

Cyanocobalamin (Vitamin B12)

  • Vitamin; essential for DNA synthesis and red blood cell maturation; treats pernicious anemia and B12 deficiency;potential adverse reactions include injection site reactions, though rare; optic nerve atrophy is a potential, rare, adverse reaction. Avoid co-administration with chloramphenicol

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