Vaccines and Immunology Quiz
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Questions and Answers

Which vaccine type utilizes a weakened form of the disease-causing organism?

  • Subcellular
  • Toxoid
  • Inactivated
  • Attenuated (correct)
  • Which of the following vaccines involves a naturally occurring, living organism?

  • Pertussis
  • Measles
  • Smallpox (correct)
  • Hepatitis B
  • Which of the following is an example of a vaccine made from a bacterial antigen?

  • Pertussis (correct)
  • Tetanus
  • Polio (Salk)
  • Meningococcal
  • Which type of vaccine uses inactivated toxins to stimulate an immune response?

    <p>Toxoid (A)</p> Signup and view all the answers

    Which of these vaccines confers life long immunity?

    <p>Measles (B)</p> Signup and view all the answers

    Which vaccine type utilizes a natural, living organism?

    <p>Small pox (C)</p> Signup and view all the answers

    Which of the following vaccines uses an attenuated organism?

    <p>Polio (Sabin) (D)</p> Signup and view all the answers

    Which type of antigen preparation is used in the Meningococcal vaccine?

    <p>Intact, non-living organism (C)</p> Signup and view all the answers

    Which of the following vaccines relies on surface antigen fragments?

    <p>Tetanus (D)</p> Signup and view all the answers

    Which type of immunity is conferred by live attenuated viral vaccines?

    <p>Life long immunity (D)</p> Signup and view all the answers

    Which route of administration is used for the Tetanus Toxoid vaccine?

    <p>Intramuscular (D)</p> Signup and view all the answers

    What volume is recommended for the DTP vaccine?

    <p>0.5 ml (B)</p> Signup and view all the answers

    In what region should the BCG vaccine be administered to an infant?

    <p>Right deltoid region of the arm (A)</p> Signup and view all the answers

    What is a potential drawback of live attenuated vaccines?

    <p>Reversion to wild type can lead to disease. (B)</p> Signup and view all the answers

    Which of the following is an example of an intact but non-living organism used as an antigenic preparation?

    <p>Virus (D)</p> Signup and view all the answers

    What is the primary difference between active and passive immunization?

    <p>Active immunization stimulates the body to produce antibodies, while passive immunization involves the administration of exogenous antibodies. (A)</p> Signup and view all the answers

    Why is the measles vaccine typically administered at 9 months of age?

    <p>To avoid interference from high concentrations of maternal antibodies present in early infancy. (A)</p> Signup and view all the answers

    Which route of administration is most likely to induce mucosal IgA antibody production?

    <p>Oral (A)</p> Signup and view all the answers

    Why do live attenuated vaccines typically provide longer-lasting immunity compared to inactivated vaccines?

    <p>Live attenuated vaccines stimulate a more comprehensive immune response, including cellular immunity and immunological memory. (C)</p> Signup and view all the answers

    What aspect of vaccine handling is crucial for maintaining the potency, especially for live attenuated vaccines?

    <p>Maintaining the cold chain (B)</p> Signup and view all the answers

    What is the recommended minimum age for administering the first dose of a DTP-containing vaccine?

    <p>6 weeks (C)</p> Signup and view all the answers

    Which of the following is a potential side effect specifically associated with the BCG vaccine?

    <p>Kochs phenomenon (C)</p> Signup and view all the answers

    What is the minimum interval recommended between the first and second doses of the Hepatitis B vaccine (excluding the birth dose)?

    <p>4 weeks (C)</p> Signup and view all the answers

    For individuals older than one year, what is the minimum interval recommended between dose 2 and dose 3 of a DTP-containing vaccine?

    <p>6 months (D)</p> Signup and view all the answers

    How is the national immunization days implemented?

    <p>Conducted for polio and measles (A)</p> Signup and view all the answers

    What is the primary mechanism by which vaccines provide immunity?

    <p>Stimulating the immune system to produce antibodies and memory cells. (A)</p> Signup and view all the answers

    Which of the following is a key characteristic that distinguishes live attenuated vaccines from inactivated vaccines?

    <p>Live attenuated vaccines replicate in the body, mimicking a natural infection, while inactivated vaccines do not. (B)</p> Signup and view all the answers

    What is the role of adjuvants in some vaccines?

    <p>To enhance the immune response to the vaccine antigen. (D)</p> Signup and view all the answers

    Which of the following is a potential disadvantage associated with live attenuated vaccines?

    <p>They pose a risk of reversion to a virulent form in rare cases. (A)</p> Signup and view all the answers

    What is the primary benefit of using mRNA vaccines compared to traditional vaccine approaches?

    <p>mRNA vaccines can be developed and produced more rapidly than traditional vaccines. (B)</p> Signup and view all the answers

    Which of the following conditions is an absolute contraindication for the administration of the BCG vaccine?

    <p>Symptomatic AIDS (B)</p> Signup and view all the answers

    What is the recommended storage temperature range for the DPT vaccine?

    <p>2°C to 8°C (C)</p> Signup and view all the answers

    A child experiences encephalopathy within 5 days of receiving a DPT vaccine dose that is not attributable to another cause. According to the guidelines, what is the next appropriate step?

    <p>The DPT vaccine is contraindicated for this child. (A)</p> Signup and view all the answers

    What does the term 'cold chain' refer to in the context of vaccine management?

    <p>The process of maintaining optimal temperature conditions during the transport, storage, and handling of vaccines. (B)</p> Signup and view all the answers

    What action should be taken if a child presents with diarrhea on the day that they are scheduled to receive OPV?

    <p>Administer the OPV, record it, and repeat the dose in 4 weeks (A)</p> Signup and view all the answers

    What is the recommended interval between the first and second doses of the Polio OPV vaccine in infants?

    <p>4 weeks (D)</p> Signup and view all the answers

    According to the provided information, superficial injection of which vaccine is most likely to cause an injection site abscess a week later?

    <p>DPT (D)</p> Signup and view all the answers

    Which of the following is generally NOT considered a contraindication for vaccination?

    <p>Mild acute illness (D)</p> Signup and view all the answers

    Which of the following describes encephalopathy for the Measles vaccine, per 100,000 vaccinations?

    <p>0.1 (C)</p> Signup and view all the answers

    If a patient is 3 years old and needs the Polio OPV vaccine, what is the recommended number of doses?

    <p>2 doses (C)</p> Signup and view all the answers

    What does the table suggest is the most common cause of side effects related to the DPT vaccine?

    <p>Pertussis component (C)</p> Signup and view all the answers

    For which vaccine is symptomatic AIDS a listed contraindication?

    <p>BCG (A)</p> Signup and view all the answers

    Which of the following is a potential major side effect associated with the Measles vaccine?

    <p>Subacute sclerosing panencephalitis (A)</p> Signup and view all the answers

    Flashcards

    Living organism vaccine example

    A vaccine derived from a living but weakened pathogen, such as the Smallpox vaccine.

    Attenuated vaccines

    Vaccines made from live organisms that have been weakened, like Measles and Polio (Sabin).

    Inactivated virus vaccine

    A type of vaccine using viruses that are killed or inactive, such as Polio (Salk).

    Capsular disaccharide vaccines

    Vaccines made from sub-cellular structures, like the Meningococcal vaccine.

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    Toxoid vaccines

    Vaccines created using inactivated toxins produced by bacteria, such as Tetanus and Diphtheria.

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    Types of Antigen

    Different categories of antigens used in vaccines.

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    Living Organism Vaccine

    Vaccines made from live microorganisms, either natural or attenuated.

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    Non-living Organisms in Vaccines

    Vaccines derived from intact but non-living organisms, such as viruses or bacteria.

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    Toxoids

    Inactivated toxins used in vaccines to stimulate immunity without disease.

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    Vaccination

    The administration of a vaccine or toxoid to prevent disease.

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    Active Immunization

    Stimulates the immune system to produce antibodies and cellular response using a vaccine.

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    Passive Immunization

    Temporary protection via exogenous antibodies or maternal antibodies.

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    Determinants of Immune Response

    Factors influencing how well a vaccine works, including age and genetics.

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    Cold Chain

    System to maintain vaccine potency through refrigeration.

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    Natural Antigen

    Antigens derived from live, attenuated organisms that simulate infection.

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    Live Attenuated Vaccines

    Vaccines that use weakened pathogens; one dose usually confers lifelong immunity.

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    Reversion to Wild Type

    Potential transformation of an attenuated vaccine back to its virulent form, causing disease.

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    DTP Vaccine Dosage

    Administered as 0.5 ml intramuscularly into the thigh.

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    BCG Vaccine Administration

    0.05-0.1 ml intradermally in the right deltoid for infants.

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    Vaccine type based on weakened pathogens

    A vaccine that uses live but weakened pathogens, stimulating an immune response without causing the disease.

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    Vaccines from killed viruses

    Vaccines that use viruses that have been completely killed or rendered inactive to prompt immunity.

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    Sub-cellular structure vaccines

    Vaccines that are derived from parts of the pathogen rather than the whole organism, used to trigger an immune response.

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    Inactivated toxins vaccines

    Vaccines made from toxins that have been rendered inactive, designed to elicit an immune response.

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    Live organisms vs. Inactivated viruses

    Contrast between vaccines made from live weakened organisms and those made from inactive viruses.

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    Kochs phenomenon

    Self-limiting inflammatory reaction occurring four days post-BCG vaccination.

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    Indolent ulcer

    Persistent ulcer over 12 weeks post-BCG, typically from injection or infection.

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    Deep abscess

    Abscess at injection site or draining lymph nodes from BCG vaccination.

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    Minimum interval between doses

    Specified time periods required between vaccinations for effectiveness.

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    Paralytic polio from OPV

    Rare occurrence of polio caused by the vaccine strain in OPV.

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    Polio OPV Schedule

    Administered at 6 weeks, then 4 weeks apart for 3 doses.

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    Rotavirus Vaccine Schedule

    Given at 6 weeks, then 4 weeks apart for 2 doses.

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    PCV Schedule

    Administered at 6 weeks, followed by 4-week intervals for 3 doses.

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    Measles Vaccine Schedule

    First dose at 9 months, followed by a second dose 4 weeks later.

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    DPT Major Side Effects

    Potential severe effects include encephalopathy, convulsions, and permanent brain damage.

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    General Vaccine Contraindications

    Includes anaphylactic reactions and moderate to severe illness.

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    BCG Contraindication

    Not recommended for individuals with symptomatic AIDS.

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    Polio OPV Age Limitation

    Not recommended for individuals older than 2 years old.

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    OPV contraindications

    Severe immune suppression is a contraindication for OPV; diarrhea is not.

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    DPT contraindications

    Encephalopathy within 7 days or poorly controlled seizures are contraindications for DPT.

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    Cold Chain importance

    Cold Chain ensures vaccines are stored and transported under optimal conditions to maintain effectiveness.

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    EPI storage temperatures

    Vaccines have specific storage temperatures; Oral polio and Measles: -15°C to 25°C, DPT and BCG: 2°C to 8°C.

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    Study Notes

    Types of Antigen Preparations

    • Living organisms (Natural): Small pox vaccine, Polio (Sabin), OPV, Measles, Mumps, Rubella, BCG, and Polio (Salk)
    • Living organisms (Attenuated):* Examples include Small pox vaccine, Polio (Sabin), OPV, Measles, Mumps, Rubella, BCG, and Polio (Salk)
    • Virus (In the intact form but non-living organisms): Pertussis
    • Bacteria (In the intact form but non-living organisms): Pertussis
    • Subcellular fragments: Capsular disaccharide, Surface antigen
    • Toxoids: Tetanus, diphtheria

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    Description

    Test your knowledge on different types of vaccines and their mechanisms of action in provoking an immune response. This quiz will cover questions on attenuated, inactivated, and toxoid vaccines, among others. Perfect for students in immunology or healthcare fields looking to reinforce their learning.

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