Cerebral Cortex

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Questions and Answers

A patient presents with difficulty initiating voluntary movements, but has normal strength and sensation. Lesions in which area are MOST likely responsible?

  • Premotor area (area 6) (correct)
  • Primary motor cortex (area 4)
  • Superior parietal lobule (areas 5 & 7)
  • Frontal eye fields (area 8)

A patient exhibits an inability to recognize objects by touch (astereognosis) and difficulties with hand-eye coordination. Where is the MOST probable location of the lesion?

  • Inferior parietal lobule (areas 40 & 39)
  • Frontal eye fields (area 8)
  • Primary motor cortex (area 4)
  • Superior parietal lobule (areas 5 & 7) (correct)

What is the MOST likely consequence of a lesion affecting Broca's area (areas 44 & 45) in the dominant hemisphere?

  • Fluent aphasia with impaired comprehension
  • Motor aphasia with telegraphic speech (correct)
  • Contralateral neglect
  • Difficulty repeating words

A patient diagnosed with Gerstmann's syndrome exhibits a cluster of deficits. Which combination of symptoms is MOST indicative of this syndrome?

<p>Acalculia, agraphia, finger agnosia, and left-right confusion (D)</p> Signup and view all the answers

Hypotonia, or decreased muscle tone, is MOST likely the result of a lesion in which of the following areas?

<p>Primary motor cortex (area 4) (C)</p> Signup and view all the answers

A patient presents with an inability to repeat spoken words, despite having intact comprehension and fluent speech. Which area is MOST likely affected?

<p>Arcuate fasciculus connecting Wernicke's and Broca's areas (C)</p> Signup and view all the answers

A person with a lesion in the non-dominant hemisphere struggles to interpret the emotional tone of speech. Which specific region is MOST likely affected?

<p>Language area (area 22) in the non-dominant hemisphere (D)</p> Signup and view all the answers

A patient with damage to their frontal eye fields exhibits deviation of the eyes. If the lesion is destructive, towards which direction will the eyes deviate?

<p>Ipsilateral to the lesion (C)</p> Signup and view all the answers

A lesion to what area of the brain would MOST likely result in contralateral neglect?

<p>Inferior parietal lobule, supramarginal and angular gyri in the non-dominant hemisphere (B)</p> Signup and view all the answers

A patient's neurological exam reveals UMN signs. Where are the lesions MOST likely located?

<p>Premotor and Primary motor cortex (D)</p> Signup and view all the answers

A patient exhibits fluent speech, severely impaired comprehension, and produces nonsensical word combinations ('word salad'). Which area is MOST likely damaged?

<p>Wernicke's area (area 22) (B)</p> Signup and view all the answers

Global aphasia, characterized by a near-complete loss of language function, is typically associated with damage to which combination of areas?

<p>Broca's area (areas 44 &amp; 45) and Wernicke's area (area 22) (A)</p> Signup and view all the answers

A patient with an irritating lesion of the frontal eye field unilaterally will MOST likely have:

<p>Deviation of eyes to the opposite side (C)</p> Signup and view all the answers

If a patient is ONLY able to make grunting sounds, what area is MOST probably lesioned?

<p>Global aphasia (areas 44, 45 &amp; post. 22) (D)</p> Signup and view all the answers

A patient has difficulty with speech, producing motor or non-fluent aphasia with telegraphic speech. Which area is MOST likely lesioned?

<p>Broca's area (areas 44 &amp; 45) (D)</p> Signup and view all the answers

A lesion to what brain area can lead to apraxia?

<p>Inferior parietal lobule, supramarginal gyri (C)</p> Signup and view all the answers

A patient's neurological exam shows difficulty forming the tone and inflection of speech. The MOST likely lesioned area is:

<p>Language area (areas 44 &amp; 45) in the non-dominant hemisphere (A)</p> Signup and view all the answers

A patient cannot understand speech and has sensory aphasia, and produces word salad when speaking. Which area is MOST likely the origin of the lesion?

<p>Wernicke's area, superior temporal gyrus (posterior) (area 22 (post.)) (C)</p> Signup and view all the answers

If a person's Frontal Eye Field is irritated, their eyes will deviate towards what side?

<p>Opposite side (D)</p> Signup and view all the answers

Which hemisphere is usually the dominant hemisphere?

<p>Left hemisphere (C)</p> Signup and view all the answers

Flashcards

Short Association Fiber

Gyrus to Gyrus

Long Association Fibers

Interconnect various areas of the cerebral cortex

Arcuate fasciculus

Connects frontal lobe (Broca's area) to the posterior superior temporal lobe (Wernicke's area)

Lesion of Arcuate fasciculus results in what?

Conduction aphasia --> problems repetiting words, understanding phrases

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Arcuate Fasciculus

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Uncinate Fasciculus - what does it connect + function

Connect anterior temporal lobe w/orbital part of frontal lobe - functions in limbics (memory, motivation, emotions)

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Cingulum - what does it connect + function

Connect the cinngulate gyrus to the parahippocampus and septal region - limbic function

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Superior Longitudinal Fasciculus - connections & function

Connects frontal lobe to the occipital and parietal lobe - eye movement function

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Yellow - Superior longitudinal fasciculus - frontal to occipital and parietal (eye movement) Red - Arcuate - frontal to temp (language) Green - Uncinate - ant temp to orbital frontal (limbic) Teal - Cingulum - cingulate gyrus to hippocampus and septal region (limbic)

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Commissural Fibers

Connect the left and right sides of the brain

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Largest comissural fiber that connects most areas of the cerebral cortex

Corpus callosum!

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What does the anterior commissure connect?

Rostral right and left temporal lobes + the 2 olfactory bulbs

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Projection fibers

Fibers that pass to and from the brainstem

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Layer 4

Primary input layer

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Layers 5 & 6

Primarily involved in output functions

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Columnar organization

Info flows Radially in cortex Info --> Inwardly Layer 4 --> Outwardly to Layer 2 --> Inwardly to layers 5 & 6

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Broca's Area Lesion (Dominant Hemisphere)

Results in motor or non-fluent aphasia, Broca's expressive aphasia, difficulty saying words, telegraphic speech

FRONTAL LOBE LESION

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Inferior Parietal Lobule Lesion Does it affect the Dominant or Non-Dominant Hemisphere?

DOMINANT Results in Apraxia

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Inferior Parietal Lobule Lesion - Sx Does it affect the Dominant or Non-Dominant Hemisphere?

DOMINANT HEMI Results in Gerstmann's syndrome: acalculia, agraphia, alexia or dyslexia, finger agnosia, L-R confusion, anomia

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Wernicke's Area Lesion - Area 22 (post) Does it affect the Dominant or Non-Dominant Hemisphere?

DOMINANT HEMISPHERE
Results in receptive or Wernicke's aphasia, lack of understanding of speech, sensory aphasia, word salad

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Conduction Aphasia lesion - symptoms and areas affected & Does it affect the Dominant or Non-Dominant Hemisphere?

DOMINANT HEMI Results in difficulty repeating words - affects areas 44, 45 and post. 22.

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Global Aphasia Lesion - Symptoms and Areas affected

DOMINANT HEMISPHERE Results in grunting sounds only - affects areas 44,45 (brocas), and posterior 22 (wernicke's)

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Inf. Parietal Lobule Lesion (Non-Dominant Hemisphere), symptoms + areas affected

Results in contralateral neglect - pt fails to respond to stimuli on contralateral side of body. Affects areas 40 & 39

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Language Area Lesion in the Non-Dominant Hemisphere in areas 44 & 45

Results in forming problems with speech tone & inflection

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Language Area Lesion in the Non-Dominant Hemisphere that affects the posterior 22 area

Results in interpreting speech tone & inflection (person can sense sarcasm for example)

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Premotor Area Lesion

Results in Apraxia - Area 6

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Primary Motor Area Lesion

Results in Hypotonia - Area 4

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Premotor & Primary Motor Lesion - symptoms and areas affected

Results in UMN symptoms - affects areas 4 & 6

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Frontal Eye Field (Destructive) Lesion - symptoms and area affected

Results in transient deviation of eyes toward the lesion - area 8 affected

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Frontal Eye Field (Irritating) Lesion - symptoms and area affected

Results in deviation of eyes to the opposite side - area 8

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Superior Parietal Lobule Lesion - Symptoms and areas affected

Results in astereognosia (can't recognize objects in hand), apraxia, loss of hand-eye coordination - arms 5 & 7 affected

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Study Notes

Algorithmic Trading Defined

  • Utilizes computer programs to execute trading orders based on predefined instructions.
  • Also known as automated trading, black-box trading, or algo-trading.
  • Algorithms consider price, timing, volume, and a variety of trading strategies.

Algorithmic Trading Workflow

  • Strategy development involves traders creating specific rules that define a trading strategy.
  • The trading strategy is translated into a computer program for automated trade execution.
  • Backtesting is performed using historical data to evaluate and optimize algorithm parameters.
  • In the execution phase, the algorithm continuously monitors the market and executes trades automatically based on the strategy.

Benefits of Algorithmic Trading

  • Enables faster trade execution than humans, taking advantage of fleeting opportunities.
  • Reduces emotional biases, leading to more rational decision-making.
  • Facilitates backtesting on historical data for strategy optimization.
  • Allows diversification across multiple markets and assets.
  • Enables execution of large orders without major market impact.

Algorithmic Trading Risks

  • Technical glitches, such as bugs in the code, can lead to unexpected and costly trades.
  • Over-optimization to historical data may result in poor live trading performance.
  • Strategies may perform poorly during high market volatility or unexpected events.
  • Changes in regulations or exchange rules can impact strategy viability.

Common Algorithmic Trading Strategies

  • Trend Following identifies and capitalizes on the direction of market trends.
  • Mean Reversion exploits the tendency of prices to revert to their average value over time.
  • Arbitrage takes advantage of price differences for the same asset in different markets.
  • Market Making provides liquidity by placing buy and sell orders close to the current price.
  • Statistical Arbitrage uses statistical models to exploit pricing inefficiencies.

Tools and Platforms for Algorithmic Trading

  • Python, Java, and C++ are commonly used programming languages.
  • MetaTrader, TradingView, and Interactive Brokers provide APIs for algorithmic trading.
  • Bloomberg and Refinitiv offer real-time market data feeds.
  • QuantConnect and Backtrader are tools that allow backtesting algorithms using historical data.

Impact of Algorithmic Trading

  • Accounts for a substantial portion of trading volume on major exchanges.
  • It has increased market efficiency and liquidity.
  • It has been associated with increased volatility and potential for flash crashes.
  • Artificial Intelligence and machine learning are being increasingly used to develop more sophisticated and adaptive strategies.
  • Cloud-based platforms are making it easier to develop, test, and deploy strategies at scale.
  • Blockchain technology has the potential to disrupt traditional trading infrastructure and enable new types of strategies.

Algorithmic Trading Conclusion

  • Offers benefits in speed, efficiency, and risk management.
  • Poses challenges related to technical complexity, regulatory compliance, and market volatility.
  • Algorithmic trading is likely to play an even larger role in the future of finance.

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