USMLE Part 1 Review
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Questions and Answers

What is the most specific antibody associated with rheumatoid arthritis?

  • Anti-cyclic citrullinated peptide (anti-CCP) (correct)
  • Rheumatoid factor (RF)
  • Antinuclear antibody (ANA)
  • Anti-dsDNA
  • Which of the following treatments for osteoarthritis should be considered first in a patient with normal BMI?

  • Corticosteroids
  • Acetaminophen (correct)
  • Naproxen
  • Weight loss
  • In a patient with rheumatoid arthritis, what is the first disease-modifying anti-rheumatic drug (DMARD) that should be initiated?

  • Sulfasalazine
  • Methotrexate (correct)
  • Leflunomide
  • Anti-TNF-alpha agent
  • What is the primary mechanism of action of methotrexate?

    <p>Dihydrofolate reductase inhibition</p> Signup and view all the answers

    Which patient group is most at risk for septic arthritis?

    <p>Patients with prosthetic joints</p> Signup and view all the answers

    What is the recommended treatment for Clostridium difficile infection?

    <p>Vancomycin</p> Signup and view all the answers

    Which organism is most likely associated with bloody diarrhea after poultry consumption?

    <p>Salmonella spp.</p> Signup and view all the answers

    In community-acquired pneumonia, what radiographic pattern is indicative of Streptococcus pneumoniae?

    <p>Lobar consolidation</p> Signup and view all the answers

    What initial diagnostic test is preferred for suspected pericardial tamponade?

    <p>Ultrasound</p> Signup and view all the answers

    Which acid-base disturbance is most commonly seen in a pulmonary embolism?

    <p>Respiratory alkalosis</p> Signup and view all the answers

    What is the first-line treatment for a pulmonary embolism in a pregnant woman?

    <p>V/Q scan</p> Signup and view all the answers

    Which treatment is most appropriate for a patient with pneumonia caused by Pseudomonas aeruginosa?

    <p>Fluoroquinolone</p> Signup and view all the answers

    What is the most common cause of otitis media?

    <p>Streptococcus pneumoniae</p> Signup and view all the answers

    What is the appropriate treatment for recurrent otitis media?

    <p>Amoxicillin/clavulanate</p> Signup and view all the answers

    What characterizes iron deficiency anemia regarding hematocrit and MCV?

    <p>Low hematocrit, low MCV, low ferritin</p> Signup and view all the answers

    In a patient with chronic disease anemia, if renal failure is the cause, what is the treatment?

    <p>Erythropoietin (EPO)</p> Signup and view all the answers

    What is the primary preventive measure for otitis externa in someone with constant water exposure?

    <p>Alcohol-acetic acid drops</p> Signup and view all the answers

    What is indicated by a low hematocrit, low MCV, and increased red cell distribution width (RDW)?

    <p>Iron deficiency anemia</p> Signup and view all the answers

    What is the best method to decrease stroke risk in a hypertensive smoker with a history of TIA?

    <p>Lisinopril</p> Signup and view all the answers

    When should tympanostomy tubes be considered?

    <p>Three or more episodes in six months</p> Signup and view all the answers

    What diagnosis should be considered for a microcytic anemia that does not improve with iron supplementation?

    <p>Thalassemia</p> Signup and view all the answers

    What is the most common causative organism of otitis externa?

    <p>Pseudomonas aeruginosa</p> Signup and view all the answers

    What is the primary acid-base disturbance observed in the first 20 minutes of aspirin toxicity?

    <p>Respiratory alkalosis</p> Signup and view all the answers

    When treating hypercalcemia above 14 mEq/L, what combination of treatments is indicated?

    <p>Normal saline and bisphosphonate</p> Signup and view all the answers

    What electrolyte disturbance is most commonly associated with low calcium or potassium that does not respond to supplementation?

    <p>Hypomagnesemia</p> Signup and view all the answers

    Which symptom is commonly seen in patients with nephrogenic diabetes insipidus due to hypercalcemia?

    <p>Polyuria</p> Signup and view all the answers

    Which of the following is a treatment option for urge incontinence?

    <p>Oxybutynin</p> Signup and view all the answers

    What is the likely diagnosis for a young African American woman presenting with a dry cough and normal chest X-ray?

    <p>Asthma</p> Signup and view all the answers

    What condition is characterized by retrograde amnesia and confabulation in an alcoholic patient?

    <p>Korsakoff psychosis</p> Signup and view all the answers

    What treatment is indicated for acute response in TCA toxicity?

    <p>Sodium bicarbonate</p> Signup and view all the answers

    What is the main cause of urinary incontinence in a patient with multiple sclerosis?

    <p>Detrusor instability</p> Signup and view all the answers

    What causes hirsutism in anovulation?

    <p>Abnormal GnRH pulsation</p> Signup and view all the answers

    Why is a high LH/FSH ratio significant in conditions like PCOS?

    <p>It prevents ovulation when the follicle is not ready</p> Signup and view all the answers

    Which treatment is preferred for PCOS if weight loss has been attempted?

    <p>Clomiphene if wanting pregnancy</p> Signup and view all the answers

    What is a significant risk factor for women with PCOS?

    <p>Endometrial cancer</p> Signup and view all the answers

    What combination of medications is commonly used for treating prostate cancer?

    <p>Flutamide and leuprolide</p> Signup and view all the answers

    In the initial treatment of acute gout, which medication is typically used first?

    <p>Indomethacin</p> Signup and view all the answers

    What should never be prescribed to patients with a history of uric acid stones?

    <p>Probenecid</p> Signup and view all the answers

    What is the enzyme deficiency associated with Lesch-Nyhan syndrome?

    <p>HGPRT</p> Signup and view all the answers

    Which type of crystals are found in pseudogout?

    <p>Calcium pyrophosphate crystals</p> Signup and view all the answers

    What is the typical presentation of pseudogout?

    <p>Monoarthritis of a large joint</p> Signup and view all the answers

    Study Notes

    USMLE Review Part I

    • This is a review of topics relevant to the USMLE Part 1 exam, covering various medical conditions.
    • Specific topics include travel-related illnesses, gastrointestinal issues (like bloody diarrhea), cardiac conditions, neurological conditions, and infectious diseases.
    • The review also covers topics such as pneumonia, cardiac ischemia, pericarditis, and various infectious diseases.
    • Medical treatments and diagnostics are highlighted for various conditions.
    • Information on various types of incontinence, including urge incontinence and overflow incontinence, are covered.
    • The document emphasizes an understanding of various conditions.
    • The review covers topics ranging from infectious diseases to neurological, cardiac and other medical conditions, providing comprehensive information for medical students.
    • The review includes details on treating and diagnosing a wide range of conditions and symptoms.
    • Key conditions include: Traveler's diarrhea, C. difficile, Entamoeba histolytica, Norwalk virus, and rotavirus
    • Diagnostic methods, treatments and their timing are important elements in this review.
    • The documents contain important information and facts on medical conditions and their treatments.

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    HY USMLE Review Part I PDF

    Description

    This quiz provides a comprehensive review of topics pertinent to the USMLE Part 1 exam, covering a variety of medical conditions. Key areas of focus include travel-related illnesses, gastrointestinal issues, cardiac and neurological conditions, as well as infectious diseases. It emphasizes understanding diagnostics and treatments for a broad range of symptoms.

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