USMLE Additional Findings Quiz
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Questions and Answers

What type of macrophages are characteristic of Follicular DLBCL?

  • Tingible body macrophages (correct)
  • Apoptotic macrophages
  • Tangible body macrophages
  • Phagocytic macrophages
  • What is the most common genetic abnormality in Follicular DLBCL?

  • t(14;18) translocation of the Bcl-2 gene (correct)
  • t(11;14) translocation involving overexpression of cyclin D
  • Deletion of the p53 gene
  • Amplification of the c-Myc gene
  • Which of the following is a characteristic of Mantle cell lymphoma?

  • Most common aggressive non-Hodgkin lymphoma
  • Presents as a painless neck mass over 1-2 years
  • t(11;14) translocation involving overexpression of cyclin D (correct)
  • Less aggressive than Sezary syndrome
  • What is the most common presentation of Mycosis fungoides?

    <p>Skin rash</p> Signup and view all the answers

    How does Warm AIHA differ from Cold AIHA?

    <p>Warm AIHA has antibodies that bind to RBCs at body temperature, Cold AIHA has antibodies that bind at lower temperatures</p> Signup and view all the answers

    What is the most common aggressive non-Hodgkin lymphoma?

    <p>Diffuse large B cell lymphoma</p> Signup and view all the answers

    What gene is involved in Burkitt lymphoma?

    <p>c-myc</p> Signup and view all the answers

    What is the gene involved in follicular lymphoma?

    <p>bcl-2</p> Signup and view all the answers

    What is the diagnosis for a 26-year-old patient with a waxing and waning neck mass and a t(14;18) chromosomal translocation?

    <p>Follicular lymphoma</p> Signup and view all the answers

    What is the diagnosis for a 41-year-old patient with lymphoma and a t(11;14) chromosomal translocation?

    <p>Mantle cell lymphoma</p> Signup and view all the answers

    What is the diagnosis for a 9-year-old patient with a low white blood cell count and cytoplasmic projections on their blood smear that stain positive for acid-resistant acid phosphatase?

    <p>Hairy cell leukemia</p> Signup and view all the answers

    What is the diagnosis for a 72-year-old patient with an acute-onset, highly aggressive B-cell lymphoma?

    <p>Diffuse large B-cell lymphoma</p> Signup and view all the answers

    Which of the following additional findings would the USMLE Q most likely give in addition to the primary diagnosis?

    <p>Mediastinal lymphadenopathy</p> Signup and view all the answers

    Which of the following B symptoms is not mandatory in vignettes according to the text?

    <p>None of the above</p> Signup and view all the answers

    What is the significance of a normal leukocyte count and differential in a Hodgkin's lymphoma patient?

    <p>It suggests the patient has a better prognosis.</p> Signup and view all the answers

    Which type of Hodgkin's lymphoma tends to favor women?

    <p>Nodular-sclerosing</p> Signup and view all the answers

    What is the significance of the $t(8;14)$ translocation in Burkitt lymphoma?

    <p>It activates the c-myc transcription factor.</p> Signup and view all the answers

    According to the given information, what is the immediate management for a patient with low platelet counts?

    <p>Steroids</p> Signup and view all the answers

    What is the most likely diagnosis for a 12-month-old with a viral infection and low neutrophil count?

    <p>Viral-induced neutropenia</p> Signup and view all the answers

    If a 12-month-old patient with viral infection, low neutrophil count, and fever is given antibiotics, what could help restore their neutrophil count?

    <p>Granulocyte-macrophage colony-stimulating factor (GM-CSF)</p> Signup and view all the answers

    What is the likely diagnosis for an 8-month-old with a viral infection, low hemoglobin, low white blood cells, and low platelets?

    <p>Aplastic anemia</p> Signup and view all the answers

    What is the likely mechanism for a 32-year-old female patient with malar rash, arthritis, low hemoglobin, low white blood cells, and low platelets?

    <p>Autoimmune disorder</p> Signup and view all the answers

    In the case of a patient with febrile neutropenia, what is the next best step for diagnosis and management?

    <p>Administer broad-spectrum antibiotics immediately</p> Signup and view all the answers

    What is the characteristic urine color found in patients with porphyria cutanea tarda?

    <p>Tea-colored</p> Signup and view all the answers

    In a patient with episodes of blistering from sun exposure and elevated urine uroporphyrin III, which compound serves as the precursor to uroporphyrin?

    <p>Succinyl-CoA</p> Signup and view all the answers

    In a patient from Albania on isoniazid (INH) therapy for latent TB, which vitamin deficiency can lead to neuropathy and seizures due to impaired heme synthesis?

    <p>Vitamin B6 deficiency</p> Signup and view all the answers

    What is the classic presentation of lead poisoning in adults?

    <p>Microcytic anemia</p> Signup and view all the answers

    Which enzyme is inhibited by lead poisoning, causing the accumulation of d-ALA and RBC protoporphyrin?

    <p>δ-ALA dehydratase</p> Signup and view all the answers

    Which vitamin is necessary for the first step of heme synthesis and can prevent neurological symptoms in patients on INH therapy?

    <p>Vitamin B6</p> Signup and view all the answers

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