29 Questions
What type of macrophages are characteristic of Follicular DLBCL?
Tingible body macrophages
What is the most common genetic abnormality in Follicular DLBCL?
t(14;18) translocation of the Bcl-2 gene
Which of the following is a characteristic of Mantle cell lymphoma?
t(11;14) translocation involving overexpression of cyclin D
What is the most common presentation of Mycosis fungoides?
Skin rash
How does Warm AIHA differ from Cold AIHA?
Warm AIHA has antibodies that bind to RBCs at body temperature, Cold AIHA has antibodies that bind at lower temperatures
What is the most common aggressive non-Hodgkin lymphoma?
Diffuse large B cell lymphoma
What gene is involved in Burkitt lymphoma?
c-myc
What is the gene involved in follicular lymphoma?
bcl-2
What is the diagnosis for a 26-year-old patient with a waxing and waning neck mass and a t(14;18) chromosomal translocation?
Follicular lymphoma
What is the diagnosis for a 41-year-old patient with lymphoma and a t(11;14) chromosomal translocation?
Mantle cell lymphoma
What is the diagnosis for a 9-year-old patient with a low white blood cell count and cytoplasmic projections on their blood smear that stain positive for acid-resistant acid phosphatase?
Hairy cell leukemia
What is the diagnosis for a 72-year-old patient with an acute-onset, highly aggressive B-cell lymphoma?
Diffuse large B-cell lymphoma
Which of the following additional findings would the USMLE Q most likely give in addition to the primary diagnosis?
Mediastinal lymphadenopathy
Which of the following B symptoms is not mandatory in vignettes according to the text?
None of the above
What is the significance of a normal leukocyte count and differential in a Hodgkin's lymphoma patient?
It suggests the patient has a better prognosis.
Which type of Hodgkin's lymphoma tends to favor women?
Nodular-sclerosing
What is the significance of the $t(8;14)$ translocation in Burkitt lymphoma?
It activates the c-myc transcription factor.
According to the given information, what is the immediate management for a patient with low platelet counts?
Steroids
What is the most likely diagnosis for a 12-month-old with a viral infection and low neutrophil count?
Viral-induced neutropenia
If a 12-month-old patient with viral infection, low neutrophil count, and fever is given antibiotics, what could help restore their neutrophil count?
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
What is the likely diagnosis for an 8-month-old with a viral infection, low hemoglobin, low white blood cells, and low platelets?
Aplastic anemia
What is the likely mechanism for a 32-year-old female patient with malar rash, arthritis, low hemoglobin, low white blood cells, and low platelets?
Autoimmune disorder
In the case of a patient with febrile neutropenia, what is the next best step for diagnosis and management?
Administer broad-spectrum antibiotics immediately
What is the characteristic urine color found in patients with porphyria cutanea tarda?
Tea-colored
In a patient with episodes of blistering from sun exposure and elevated urine uroporphyrin III, which compound serves as the precursor to uroporphyrin?
Succinyl-CoA
In a patient from Albania on isoniazid (INH) therapy for latent TB, which vitamin deficiency can lead to neuropathy and seizures due to impaired heme synthesis?
Vitamin B6 deficiency
What is the classic presentation of lead poisoning in adults?
Microcytic anemia
Which enzyme is inhibited by lead poisoning, causing the accumulation of d-ALA and RBC protoporphyrin?
δ-ALA dehydratase
Which vitamin is necessary for the first step of heme synthesis and can prevent neurological symptoms in patients on INH therapy?
Vitamin B6
Test your knowledge on additional findings in USMLE questions, such as hepatomegaly, mediastinal mass, Virchow node, and B symptoms. Understand when these findings are common and their significance in clinical scenarios.
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